IgT and IgD dominance in the teleost central nervous system

[Data availability statement] The data discussed in this publication has been deposited in NCBI’s BioProject database and is accessible through the BioProject accession number PRJNA1308505 (http://www.ncbi.nlm.nih.gov/bioproject/1308505).

Detalles Bibliográficos
Autores: Vicente-Gil, Samuel, Pianese, Valeria, Morel, Esther, Abós, Beatriz, Jiménez-Barrios, Pablo, Perdiguero, Pedro, Martín, Diana, Simón, Rocío, Picchietti, Simona, Scapigliati, Giuseppe, Tafalla, Carolina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/406701
Acceso en línea:http://hdl.handle.net/10261/406701
https://api.elsevier.com/content/abstract/scopus_id/105015590828
Access Level:acceso abierto
Palabra clave:B cells
IgD
IgT
Central nervous system
Rainbow trout
Teleost
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spelling IgT and IgD dominance in the teleost central nervous systemVicente-Gil, SamuelPianese, ValeriaMorel, EstherAbós, BeatrizJiménez-Barrios, PabloPerdiguero, PedroMartín, DianaSimón, RocíoPicchietti, SimonaScapigliati, GiuseppeTafalla, CarolinaB cellsIgDIgTCentral nervous systemRainbow troutTeleost[Data availability statement] The data discussed in this publication has been deposited in NCBI’s BioProject database and is accessible through the BioProject accession number PRJNA1308505 (http://www.ncbi.nlm.nih.gov/bioproject/1308505).Although initially described as an immune-privileged site, the central nervous system (CNS) is now known to harbor a resident immune system, composed of different innate and adaptive cell types that maintain tissue homeostasis, are regulated in pathological conditions or brain injury and are in connection with the peripheral immune system. However, information regarding a characterization of the B cell subsets colonizing the CNS or their precise role is very scarce in mammals and even more in fish. Teleost fish exclusively express IgM, IgD and the teleost-specific IgT and their expression patterns in B cells define diverse B cell subsets. IgM is the main Ig isotype in systemic responses, while previous evidence suggested a mucosally dedicated role for IgT. Recent work by our group and others, also pointed to a role for IgD in maintaining mucosal homeostasis. However, in the current study, we demonstrate through different techniques that IgD+ and IgT+ expressing B cells are predominant in the teleost CNS, albeit a very different distribution. Additionally, B cell receptor (BCR) repertoire analysis pointed to both populations as antigen-experienced. Further research is needed to fully elucidate the specific roles of IgT and IgD in the teleost brain, but this discovery opens exciting avenues for future investigations in the fields of immunology and neuroscience.The author(s) declare financial support was received for the research and/or publication of this article. The research was funded by the Spanish Ministry of Science and Innovation (grant number PID2023-148142NB-I00 funded by MCNI/AEI/10.13039/501100011033). We acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative (PROA) through its Unit of Information Resources for Research (URICI).Peer reviewedFrontiers MediaEuropean CommissionAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)Jiménez-Barrios, Pablo [0000-0001-8288-5292]Perdiguero, Pedro [0000-0002-5471-9550]Martín, Diana [0000-0002-1082-9280]Simón, Rocío [0000-0001-6584-5141]Tafalla, Carolina [0000-0002-0860-2976]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/406701https://api.elsevier.com/content/abstract/scopus_id/105015590828reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-148142NB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3389/fimmu.2025.1657738https://doi.org/10.3389/fimmu.2025.1657738Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4067012026-05-22T06:33:51Z
dc.title.none.fl_str_mv IgT and IgD dominance in the teleost central nervous system
title IgT and IgD dominance in the teleost central nervous system
spellingShingle IgT and IgD dominance in the teleost central nervous system
Vicente-Gil, Samuel
B cells
IgD
IgT
Central nervous system
Rainbow trout
Teleost
title_short IgT and IgD dominance in the teleost central nervous system
title_full IgT and IgD dominance in the teleost central nervous system
title_fullStr IgT and IgD dominance in the teleost central nervous system
title_full_unstemmed IgT and IgD dominance in the teleost central nervous system
title_sort IgT and IgD dominance in the teleost central nervous system
dc.creator.none.fl_str_mv Vicente-Gil, Samuel
Pianese, Valeria
Morel, Esther
Abós, Beatriz
Jiménez-Barrios, Pablo
Perdiguero, Pedro
Martín, Diana
Simón, Rocío
Picchietti, Simona
Scapigliati, Giuseppe
Tafalla, Carolina
author Vicente-Gil, Samuel
author_facet Vicente-Gil, Samuel
Pianese, Valeria
Morel, Esther
Abós, Beatriz
Jiménez-Barrios, Pablo
Perdiguero, Pedro
Martín, Diana
Simón, Rocío
Picchietti, Simona
Scapigliati, Giuseppe
Tafalla, Carolina
author_role author
author2 Pianese, Valeria
Morel, Esther
Abós, Beatriz
Jiménez-Barrios, Pablo
Perdiguero, Pedro
Martín, Diana
Simón, Rocío
Picchietti, Simona
Scapigliati, Giuseppe
Tafalla, Carolina
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)
Jiménez-Barrios, Pablo [0000-0001-8288-5292]
Perdiguero, Pedro [0000-0002-5471-9550]
Martín, Diana [0000-0002-1082-9280]
Simón, Rocío [0000-0001-6584-5141]
Tafalla, Carolina [0000-0002-0860-2976]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv B cells
IgD
IgT
Central nervous system
Rainbow trout
Teleost
topic B cells
IgD
IgT
Central nervous system
Rainbow trout
Teleost
description [Data availability statement] The data discussed in this publication has been deposited in NCBI’s BioProject database and is accessible through the BioProject accession number PRJNA1308505 (http://www.ncbi.nlm.nih.gov/bioproject/1308505).
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/406701
https://api.elsevier.com/content/abstract/scopus_id/105015590828
url http://hdl.handle.net/10261/406701
https://api.elsevier.com/content/abstract/scopus_id/105015590828
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-148142NB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3389/fimmu.2025.1657738
https://doi.org/10.3389/fimmu.2025.1657738
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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