Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.

The role of metals and metalloids beyond arsenic, copper, lead and cadmium in cardiovascular disease is not entirely clear. The aim of this study was to assess the association between 18 metal or metalloid levels in topsoil (upper soil horizon) with all-cause and specific cardiovascular mortality en...

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Detalles Bibliográficos
Autores: Ayuso-Alvarez, Ana Maria, Nuñez, Olivier, Martín-Méndez, Iván, Bel-Lán, Alejandro, Tellez-Plaza, Maria, Perez-Gomez, Beatriz, Galan, Iñaki, Fernandez-Navarro, Pablo L
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/27197
Acceso en línea:https://hdl.handle.net/20.500.12105/27197
Access Level:acceso abierto
Palabra clave:Cardiovascular mortality
Environmental exposure
Metalloid
Metals
Spatial models
Topsoil
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spelling Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.Ayuso-Alvarez, Ana MariaNuñez, OlivierMartín-Méndez, IvánBel-Lán, AlejandroTellez-Plaza, MariaPerez-Gomez, BeatrizGalan, IñakiFernandez-Navarro, Pablo LCardiovascular mortalityEnvironmental exposureMetalloidMetalsSpatial modelsTopsoilThe role of metals and metalloids beyond arsenic, copper, lead and cadmium in cardiovascular disease is not entirely clear. The aim of this study was to assess the association between 18 metal or metalloid levels in topsoil (upper soil horizon) with all-cause and specific cardiovascular mortality endpoints in Spain. We designed an ecological spatial study, to assess cardiovascular mortality in 7941 Spanish mainland towns from 2010 to 2014. The estimation of metals and metalloids concentration in topsoil came from the Geochemical Atlas of Spain from 13,317 soil samples. We also summarized the joint variability of the metals using principal components analysis (PCA). These components (PCs) were included in a Besag, York, and Mollié model to assess their association with cardiovascular mortality from all causes, coronary heart disease, cerebrovascular, hypertension, and conduction disorders. Our results showed, both in men and women, that at the lowest component scores range, PC2 (mainly reflecting Al, Be, Tl and U) was positively associated with coronary heart disease and cerebrovascular mortality. At medium/highest scores range, PC4 (mainly reflecting Hg) was positively associated with cerebrovascular mortality. For PC3 (reflecting Se), the association with coronary heart disease mortality was positive only in men at the highest PC scores range. For PC1 (partly reflecting metals such as Pb, As, Cu or Cd), we observed a strongly suggestive positive association with all-cause cardiovascular diseases mortality. Our ecological results are consistent with the available evidence supporting a cardiovascular role of excessive exposure to Se, Hg, Pb, As, Cu and Cd, but also identify Al, Be, Tl and U as potentially novel cardiovascular factors. Additional research is needed to confirm the biological relevance of our findings.Elsevier20262026-01-2920222022-03-0120222022-03-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/20.500.12105/27197reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/271972026-06-12T12:43:37Z
dc.title.none.fl_str_mv Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
title Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
spellingShingle Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
Ayuso-Alvarez, Ana Maria
Cardiovascular mortality
Environmental exposure
Metalloid
Metals
Spatial models
Topsoil
title_short Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
title_full Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
title_fullStr Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
title_full_unstemmed Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
title_sort Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain.
dc.creator.none.fl_str_mv Ayuso-Alvarez, Ana Maria
Nuñez, Olivier
Martín-Méndez, Iván
Bel-Lán, Alejandro
Tellez-Plaza, Maria
Perez-Gomez, Beatriz
Galan, Iñaki
Fernandez-Navarro, Pablo L
author Ayuso-Alvarez, Ana Maria
author_facet Ayuso-Alvarez, Ana Maria
Nuñez, Olivier
Martín-Méndez, Iván
Bel-Lán, Alejandro
Tellez-Plaza, Maria
Perez-Gomez, Beatriz
Galan, Iñaki
Fernandez-Navarro, Pablo L
author_role author
author2 Nuñez, Olivier
Martín-Méndez, Iván
Bel-Lán, Alejandro
Tellez-Plaza, Maria
Perez-Gomez, Beatriz
Galan, Iñaki
Fernandez-Navarro, Pablo L
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Cardiovascular mortality
Environmental exposure
Metalloid
Metals
Spatial models
Topsoil
topic Cardiovascular mortality
Environmental exposure
Metalloid
Metals
Spatial models
Topsoil
description The role of metals and metalloids beyond arsenic, copper, lead and cadmium in cardiovascular disease is not entirely clear. The aim of this study was to assess the association between 18 metal or metalloid levels in topsoil (upper soil horizon) with all-cause and specific cardiovascular mortality endpoints in Spain. We designed an ecological spatial study, to assess cardiovascular mortality in 7941 Spanish mainland towns from 2010 to 2014. The estimation of metals and metalloids concentration in topsoil came from the Geochemical Atlas of Spain from 13,317 soil samples. We also summarized the joint variability of the metals using principal components analysis (PCA). These components (PCs) were included in a Besag, York, and Mollié model to assess their association with cardiovascular mortality from all causes, coronary heart disease, cerebrovascular, hypertension, and conduction disorders. Our results showed, both in men and women, that at the lowest component scores range, PC2 (mainly reflecting Al, Be, Tl and U) was positively associated with coronary heart disease and cerebrovascular mortality. At medium/highest scores range, PC4 (mainly reflecting Hg) was positively associated with cerebrovascular mortality. For PC3 (reflecting Se), the association with coronary heart disease mortality was positive only in men at the highest PC scores range. For PC1 (partly reflecting metals such as Pb, As, Cu or Cd), we observed a strongly suggestive positive association with all-cause cardiovascular diseases mortality. Our ecological results are consistent with the available evidence supporting a cardiovascular role of excessive exposure to Se, Hg, Pb, As, Cu and Cd, but also identify Al, Be, Tl and U as potentially novel cardiovascular factors. Additional research is needed to confirm the biological relevance of our findings.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-01
2022
2022-03-01
2026
2026-01-29
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/27197
url https://hdl.handle.net/20.500.12105/27197
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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