Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins

Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or...

Full description

Bibliographic Details
Authors: Medina Escudero, Sonia, Gil-Izquierdo, Ángel, Durand, Thierry, Ferreres, Federico, Domínguez-Perles, Raúl
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/172529
Online Access:http://hdl.handle.net/10261/172529
Access Level:Open access
Keyword:Plant oxylipins
Mammals oxylipins
Structural analogy
Biological activities
SAR
id ES_928afb620cd4450a8a9fe9fad16dfa43
oai_identifier_str oai:digital.csic.es:10261/172529
network_acronym_str ES
network_name_str España
repository_id_str
spelling Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipinsMedina Escudero, SoniaGil-Izquierdo, ÁngelDurand, ThierryFerreres, FedericoDomínguez-Perles, RaúlPlant oxylipinsMammals oxylipinsStructural analogyBiological activitiesSARStructure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern high throughput analytical approaches and techniques allow to overwhelm the constraints adduced so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods, and the information available on their bioavailability and biological activity, shedding some light on the expectation waken up due to their structural similarities with prostanoids and isoprostanes.This work was partially funded by the ‘Fundación Séneca de la Región de Murcia’ Grupo de Excelencia 19900/GERM/15 and the Spanish project AGL2017-83386-R fron the Spanish Ministry of Science, Innovation and Universities. This work is included in the framework of the collaboration between the Spanish Research Council (CEBAS-CSIC) and CNRS-University of Montpellier by ‘Projets Internationaux de Cooperation Scientifique’ (PICS-2015-261141). RDP and SM were supported by a Postdoctoral Contract Juan de la Cierva de Incorporación (ICJI-2015-25373) from the Ministry of Economy, Industry and Competitiveness of Spain and a PostDoctoral fellowship (ARDITI-CQM/2017/008-PDG) granted by ARDITI- CQM+ project M1420-01-0145-FEDER-000005, respectively.Peer reviewedMultidisciplinary Digital Publishing InstituteFundación SénecaAgencia Estatal de Investigación (España)Ministerio de Economía, Industria y Competitividad (España)Université de MontpellierCentre National de la Recherche Scientifique (France)Consejo Superior de Investigaciones Científicas (España)Ministerio de Economía y Competitividad (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/172529reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#AGL2017-83386-R/AEI/10.13039/501100011033info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-83386-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/IJCI-2015-25373info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/ICJI-2015-25373https://doi.org/10.3390/antiox7110165Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1725292026-05-22T06:33:51Z
dc.title.none.fl_str_mv Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
title Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
spellingShingle Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
Medina Escudero, Sonia
Plant oxylipins
Mammals oxylipins
Structural analogy
Biological activities
SAR
title_short Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
title_full Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
title_fullStr Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
title_full_unstemmed Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
title_sort Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins
dc.creator.none.fl_str_mv Medina Escudero, Sonia
Gil-Izquierdo, Ángel
Durand, Thierry
Ferreres, Federico
Domínguez-Perles, Raúl
author Medina Escudero, Sonia
author_facet Medina Escudero, Sonia
Gil-Izquierdo, Ángel
Durand, Thierry
Ferreres, Federico
Domínguez-Perles, Raúl
author_role author
author2 Gil-Izquierdo, Ángel
Durand, Thierry
Ferreres, Federico
Domínguez-Perles, Raúl
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Fundación Séneca
Agencia Estatal de Investigación (España)
Ministerio de Economía, Industria y Competitividad (España)
Université de Montpellier
Centre National de la Recherche Scientifique (France)
Consejo Superior de Investigaciones Científicas (España)
Ministerio de Economía y Competitividad (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Plant oxylipins
Mammals oxylipins
Structural analogy
Biological activities
SAR
topic Plant oxylipins
Mammals oxylipins
Structural analogy
Biological activities
SAR
description Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern high throughput analytical approaches and techniques allow to overwhelm the constraints adduced so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods, and the information available on their bioavailability and biological activity, shedding some light on the expectation waken up due to their structural similarities with prostanoids and isoprostanes.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/172529
url http://hdl.handle.net/10261/172529
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
AGL2017-83386-R/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-83386-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/IJCI-2015-25373
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/ICJI-2015-25373
https://doi.org/10.3390/antiox7110165
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413479602978816
score 15,811543

Similar Items