The burden of chronic spontaneous urticaria is substantial
Chronic spontaneous urticaria () can be debilitating, difficult to treat, and frustrating for patients and physicians. Real-world evidence for the burden of is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health-...
| Autores: | , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:186252 |
| Acceso en línea: | https://ddd.uab.cat/record/186252 https://dx.doi.org/urn:doi:10.1111/all.13209 |
| Access Level: | acceso abierto |
| Palabra clave: | Angioedema Economic burden Observational study Quality of life Urticaria |
| Sumario: | Chronic spontaneous urticaria () can be debilitating, difficult to treat, and frustrating for patients and physicians. Real-world evidence for the burden of is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health-related quality of life (oL) and work among patients with inadequately controlled , and to describe its humanistic, societal, and economic burden. This international observational study assessed a cohort of 673 adult patients with whose symptoms persisted for ≥12 months despite treatment. Demographics, disease characteristics, and healthcare resource use in the previous 12 months were collected from medical records. Patient-reported data on urticaria and angioedema symptoms, oL, and work productivity and activity impairment were collected from a survey and a diary. Almost 50% of patients had moderate-to-severe disease activity as reported by Urticaria Activity Score. Mean () Dermatology Life Quality Index and Chronic Urticaria Quality of Life Questionnaire scores were 9.1 (6.62) and 33.6 (20.99), respectively. Chronic spontaneous urticaria markedly interfered with sleep and daily activities. Angioedema in the previous 12 months was reported by 66% of enrolled patients and significantly affected oL. More than 20% of patients reported ≥1 hour per week of missed work; productivity impairment was 27%. These effects increased with increasing disease activity. Significant healthcare resources and costs were incurred to treat . Chronic spontaneous urticaria has considerable humanistic and economic impacts. Patients with greater disease activity and with angioedema experience greater oL impairments. |
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