The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes

Adult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrin...

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Detalles Bibliográficos
Autores: Sarubbo, Fiorella, Cavallucci, Virve, Pani, Giovambattista
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23540
Acceso en línea:https://hdl.handle.net/20.500.12105/23540
Access Level:acceso abierto
Palabra clave:Gut microbiota
Gut-brain axis
Adult neurogenesis
Ageing
Neural stem cells
Neurodegeneration
Nutrients
Antioxidants
Polyphenols
Animales
Microbiota
Neurogénesis
Encéfalo
Prebióticos
Microbioma Gastrointestinal
Brain
Neurogenesis
Gastrointestinal Microbiome
Prebiotics
Animals
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spelling The Influence of Gut Microbiota on Neurogenesis: Evidence and HopesSarubbo, FiorellaCavallucci, VirvePani, GiovambattistaGut microbiotaGut-brain axisAdult neurogenesisAgeingNeural stem cellsNeurodegenerationNutrientsAntioxidantsPolyphenolsAnimalesMicrobiotaNeurogénesisEncéfaloPrebióticosMicrobioma GastrointestinalBrainNeurogenesisGastrointestinal MicrobiomeMicrobiotaPrebioticsAnimalsAdult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrinsic (oxidative stress, inflammation, and ageing), and extrinsic (environmental pollution, lifestyle, and diet) factors deemed to impact neurogenesis, significant attention has been recently attracted by the myriad of saprophytic microorganismal communities inhabiting the intestinal ecosystem and collectively referred to as the gut microbiota. A growing body of evidence, mainly from animal studies, reveal the influence of microbiota and its disease-associated imbalances on neural stem cell proliferative and differentiative activities in brain neurogenic niches. On the other hand, the long-claimed pro-neurogenic activity of natural dietary compounds endowed with antioxidants and anti-inflammatory properties (such as polyphenols, polyunsaturated fatty acids, or pro/prebiotics) may be mediated, at least in part, by their action on the intestinal microflora. The purpose of this review is to summarise the available information regarding the influence of the gut microbiota on neurogenesis, analyse the possible underlying mechanisms, and discuss the potential implications of this emerging knowledge for the fight against neurodegeneration and brain ageing.Multidisciplinary Digital Publishing Institute (MDPI)20242024-10-0420222022-02-0120222022-02-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23540reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/235402026-06-12T12:43:37Z
dc.title.none.fl_str_mv The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
title The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
spellingShingle The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, Fiorella
Gut microbiota
Gut-brain axis
Adult neurogenesis
Ageing
Neural stem cells
Neurodegeneration
Nutrients
Antioxidants
Polyphenols
Animales
Microbiota
Neurogénesis
Encéfalo
Prebióticos
Microbioma Gastrointestinal
Brain
Neurogenesis
Gastrointestinal Microbiome
Microbiota
Prebiotics
Animals
title_short The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
title_full The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
title_fullStr The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
title_full_unstemmed The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
title_sort The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
dc.creator.none.fl_str_mv Sarubbo, Fiorella
Cavallucci, Virve
Pani, Giovambattista
author Sarubbo, Fiorella
author_facet Sarubbo, Fiorella
Cavallucci, Virve
Pani, Giovambattista
author_role author
author2 Cavallucci, Virve
Pani, Giovambattista
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Gut microbiota
Gut-brain axis
Adult neurogenesis
Ageing
Neural stem cells
Neurodegeneration
Nutrients
Antioxidants
Polyphenols
Animales
Microbiota
Neurogénesis
Encéfalo
Prebióticos
Microbioma Gastrointestinal
Brain
Neurogenesis
Gastrointestinal Microbiome
Microbiota
Prebiotics
Animals
topic Gut microbiota
Gut-brain axis
Adult neurogenesis
Ageing
Neural stem cells
Neurodegeneration
Nutrients
Antioxidants
Polyphenols
Animales
Microbiota
Neurogénesis
Encéfalo
Prebióticos
Microbioma Gastrointestinal
Brain
Neurogenesis
Gastrointestinal Microbiome
Microbiota
Prebiotics
Animals
description Adult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrinsic (oxidative stress, inflammation, and ageing), and extrinsic (environmental pollution, lifestyle, and diet) factors deemed to impact neurogenesis, significant attention has been recently attracted by the myriad of saprophytic microorganismal communities inhabiting the intestinal ecosystem and collectively referred to as the gut microbiota. A growing body of evidence, mainly from animal studies, reveal the influence of microbiota and its disease-associated imbalances on neural stem cell proliferative and differentiative activities in brain neurogenic niches. On the other hand, the long-claimed pro-neurogenic activity of natural dietary compounds endowed with antioxidants and anti-inflammatory properties (such as polyphenols, polyunsaturated fatty acids, or pro/prebiotics) may be mediated, at least in part, by their action on the intestinal microflora. The purpose of this review is to summarise the available information regarding the influence of the gut microbiota on neurogenesis, analyse the possible underlying mechanisms, and discuss the potential implications of this emerging knowledge for the fight against neurodegeneration and brain ageing.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-02-01
2022
2022-02-01
2024
2024-10-04
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23540
url https://hdl.handle.net/20.500.12105/23540
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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