Role of CB2 cannabinoid receptor in nociception and food intake control
The endocannabinoid system is a natural modulatory system that participates in multiple physiological processes, including nociceptive, emotional and rewarding responses. These central responses are mainly mediated by cannabinoid receptor 1 (CB1R)-dependent mechanisms, although the side effects asso...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/672620 |
| Acceso en línea: | http://hdl.handle.net/10803/672620 |
| Access Level: | acceso abierto |
| Palabra clave: | Endocannabinoid system CB2 receptors Neuropathic pain Food addiction Depression Sistema endocannabinoide Receptores CB2 Dolor neuropático Adicción a la comida Depresión 616.8 |
| Sumario: | The endocannabinoid system is a natural modulatory system that participates in multiple physiological processes, including nociceptive, emotional and rewarding responses. These central responses are mainly mediated by cannabinoid receptor 1 (CB1R)-dependent mechanisms, although the side effects associated to these central responses limit the therapeutic use of CB1R agonists. Recent research on the cannabinoid receptor 2 (CB2R) provides an alternative approach to avoid the central side effects associated with CB1R stimulation. The purpose of this Thesis was to investigate the involvement of CB2R in two different pathological conditions that currently lack effective treatment: neuropathic pain and food addiction. The results revealed that the pain-resistant phenotype of Fmr1KO mice against the nociceptive and emotional manifestations triggered by persistent nerve damage requires the participation of CB2R. We also demonstrated that CB2R are involved in the neurobiological substrate underlying the behavioral and affective alterations that arise from food addiction. Altogether, these data highlight the potential therapeutic interest of targeting CB2R for the treatment of neuropathic pain, food addiction disorders and their co-morbid emotional manifestations. |
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