Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection

BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short-term mortality with bacterial infection frequently as precipitating event. Innate immune pattern recognition receptors and members of the l...

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Autores: Schaapman, Jelte J., Amorós, Àlex, Reijden, Johan J. van der, Laleman, Wim, Zeuzem, Stefan, Bañares, Rafael, Jalan, Rajiv, Arroyo, Vicente, Clària i Enrich, Joan, Verspaget, Hein W., Coenraad, Minneke J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/159818
Acceso en línea:https://hdl.handle.net/2445/159818
Access Level:acceso abierto
Palabra clave:Mortalitat
Malalties bacterianes
Cirrosi hepàtica
Genètica mèdica
Mortality
Bacterial diseases
Hepatic cirrhosis
Medical genetics
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spelling Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infectionSchaapman, Jelte J.Amorós, ÀlexReijden, Johan J. van derLaleman, WimZeuzem, StefanBañares, RafaelJalan, RajivArroyo, VicenteClària i Enrich, JoanVerspaget, Hein W.Coenraad, Minneke J.MortalitatMalalties bacterianesCirrosi hepàticaGenètica mèdicaMortalityBacterial diseasesHepatic cirrhosisMedical geneticsBACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short-term mortality with bacterial infection frequently as precipitating event. Innate immune pattern recognition receptors and members of the lectin pathway of complement activation are crucial to the innate immune response to pathogens. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of innate immune components are associated with the occurrence of bacterial infections or mortality in patients with cirrhosis hospitalized for AD or ACLF. METHODS: Twenty-one innate immunity SNPs with known functional implications were genotyped in 826 AD/ACLF patients included in the CANONIC study. Associations between baseline characteristics of the patients, the occurrence of bacterial infections and survival rate at 90 days of follow-up in relation to the innate immunity genetic variants were analysed. RESULTS: The NOD2-G908R genetic variant was associated with mortality (HR 2.25, P = .004) independently of age and MELD Score. This association was also found in a predefined subgroup analysis in patients with bacterial infections (HR 2.78, P < .001) along with MBL_Yx (HR 1.72, P = .008) and MASP2_371 (HR 1.67, P = .012) genetic variants. None of the analysed SNPs were significantly associated with the occurrence of acute bacterial infections or spontaneous bacterial peritonitis in particular. CONCLUSIONS: Innate immune system-specific NOD2-G908R, MBL_Yx and MASP2_371 genetic variants were independently associated with increased risk of short-term mortality in AD/ACLF patients with bacterial infection.John Wiley & Sons2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/159818Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1111/liv.14392Liver International, 2020, vol. 40, num. 3, p. 646-653https://doi.org/10.1111/liv.14392cc by-nc-nd (c) Schaapman et al., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1598182026-05-27T06:46:51Z
dc.title.none.fl_str_mv Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
title Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
spellingShingle Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
Schaapman, Jelte J.
Mortalitat
Malalties bacterianes
Cirrosi hepàtica
Genètica mèdica
Mortality
Bacterial diseases
Hepatic cirrhosis
Medical genetics
title_short Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
title_full Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
title_fullStr Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
title_full_unstemmed Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
title_sort Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
dc.creator.none.fl_str_mv Schaapman, Jelte J.
Amorós, Àlex
Reijden, Johan J. van der
Laleman, Wim
Zeuzem, Stefan
Bañares, Rafael
Jalan, Rajiv
Arroyo, Vicente
Clària i Enrich, Joan
Verspaget, Hein W.
Coenraad, Minneke J.
author Schaapman, Jelte J.
author_facet Schaapman, Jelte J.
Amorós, Àlex
Reijden, Johan J. van der
Laleman, Wim
Zeuzem, Stefan
Bañares, Rafael
Jalan, Rajiv
Arroyo, Vicente
Clària i Enrich, Joan
Verspaget, Hein W.
Coenraad, Minneke J.
author_role author
author2 Amorós, Àlex
Reijden, Johan J. van der
Laleman, Wim
Zeuzem, Stefan
Bañares, Rafael
Jalan, Rajiv
Arroyo, Vicente
Clària i Enrich, Joan
Verspaget, Hein W.
Coenraad, Minneke J.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mortalitat
Malalties bacterianes
Cirrosi hepàtica
Genètica mèdica
Mortality
Bacterial diseases
Hepatic cirrhosis
Medical genetics
topic Mortalitat
Malalties bacterianes
Cirrosi hepàtica
Genètica mèdica
Mortality
Bacterial diseases
Hepatic cirrhosis
Medical genetics
description BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short-term mortality with bacterial infection frequently as precipitating event. Innate immune pattern recognition receptors and members of the lectin pathway of complement activation are crucial to the innate immune response to pathogens. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of innate immune components are associated with the occurrence of bacterial infections or mortality in patients with cirrhosis hospitalized for AD or ACLF. METHODS: Twenty-one innate immunity SNPs with known functional implications were genotyped in 826 AD/ACLF patients included in the CANONIC study. Associations between baseline characteristics of the patients, the occurrence of bacterial infections and survival rate at 90 days of follow-up in relation to the innate immunity genetic variants were analysed. RESULTS: The NOD2-G908R genetic variant was associated with mortality (HR 2.25, P = .004) independently of age and MELD Score. This association was also found in a predefined subgroup analysis in patients with bacterial infections (HR 2.78, P < .001) along with MBL_Yx (HR 1.72, P = .008) and MASP2_371 (HR 1.67, P = .012) genetic variants. None of the analysed SNPs were significantly associated with the occurrence of acute bacterial infections or spontaneous bacterial peritonitis in particular. CONCLUSIONS: Innate immune system-specific NOD2-G908R, MBL_Yx and MASP2_371 genetic variants were independently associated with increased risk of short-term mortality in AD/ACLF patients with bacterial infection.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/159818
url https://hdl.handle.net/2445/159818
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1111/liv.14392
Liver International, 2020, vol. 40, num. 3, p. 646-653
https://doi.org/10.1111/liv.14392
dc.rights.none.fl_str_mv cc by-nc-nd (c) Schaapman et al., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Schaapman et al., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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