Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups

Galaxolide (HHCB) and tonalide (AHTN) are polycyclic musk compounds (PMCs) used in household and personal care products that have been included on the list as emerging contaminants of environmental concern due to their ubiquity in aquatic and terrestrial environments. There still exists a dearth of...

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Autores: Ehiguese, Friday Ojie, Rodgers, Maria L., Araújo, Cristiano V. M., Griffitt, Robert J., Martín-Díaz, M. Laura
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/253541
Acceso en línea:http://hdl.handle.net/10261/253541
Access Level:acceso abierto
Palabra clave:Neurotoxicity
Endocrine disruption
Galaxolide
Tonalide
Transcriptional effects
Biomarkers
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spelling Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groupsEhiguese, Friday OjieRodgers, Maria L.Araújo, Cristiano V. M.Griffitt, Robert J.Martín-Díaz, M. LauraNeurotoxicityEndocrine disruptionGalaxolideTonalideTranscriptional effectsBiomarkersGalaxolide (HHCB) and tonalide (AHTN) are polycyclic musk compounds (PMCs) used in household and personal care products that have been included on the list as emerging contaminants of environmental concern due to their ubiquity in aquatic and terrestrial environments. There still exists a dearth of information on the neurotoxicity and endocrine disrupting effects of these contaminants, especially for marine and estuarine species. Here, we assessed the neuroendocrine effects of HHCB and AHTN using adult clams, Ruditapes philippinarum, and yolk-sac larvae of sheepshead minnow, Cyprinodon variegatus. The clams were treated with concentrations (0.005–50 μg/L) of each compound for 21 days. Meanwhile, sheepshead minnow larvae were exposed to 0.5, 5 and 50 μg/L of HHCB and AHTN for 3 days. Enzyme activities related to neurotoxicity (acetylcholinesterase - AChE), neuroendocrine function (cyclooxygenase - COX), and energy reserves (total lipids - TL) were assessed in R. philippinarum. Gene expression levels of cyp19 and vtg1 were measured in C. variegatus using qPCR. Our results indicated induction of AChE and COX in the clams exposed to HHCB while AHTN exposure significantly inhibited AChE and COX. Gene expression of cyp19 and vtg1 in yolk-sac C. variegatus larvae exposed to 50 μg/L AHTN was significantly downregulated versus the control. The results of this study demonstrate that HHCB and AHTN might pose neurotoxic and endocrine disrupting effects in coastal ecosystems.This research was supported by the Spanish Ministry of Economy and Competitiveness (Ref. CTM2012-37591), FEDER Funds from the European Union. The first author sincerely appreciates the Erasmus + KA 107 UCA grant for the research stay at the University of Southern Mississippi. C.V.M. Araújo is grateful to the Spanish Ministry of Science and Innovation for the Ramón y Cajal (RYC-2017-22324) contract.ElsevierMinisterio de Economía y Competitividad (España)European CommissionUniversity of Southern MississippiMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/253541reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//RYC-2017-22324http://dx.doi.org/10.1016/j.envres.2021.110960Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2535412026-05-22T06:33:51Z
dc.title.none.fl_str_mv Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
title Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
spellingShingle Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
Ehiguese, Friday Ojie
Neurotoxicity
Endocrine disruption
Galaxolide
Tonalide
Transcriptional effects
Biomarkers
title_short Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
title_full Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
title_fullStr Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
title_full_unstemmed Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
title_sort Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups
dc.creator.none.fl_str_mv Ehiguese, Friday Ojie
Rodgers, Maria L.
Araújo, Cristiano V. M.
Griffitt, Robert J.
Martín-Díaz, M. Laura
author Ehiguese, Friday Ojie
author_facet Ehiguese, Friday Ojie
Rodgers, Maria L.
Araújo, Cristiano V. M.
Griffitt, Robert J.
Martín-Díaz, M. Laura
author_role author
author2 Rodgers, Maria L.
Araújo, Cristiano V. M.
Griffitt, Robert J.
Martín-Díaz, M. Laura
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
University of Southern Mississippi
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Neurotoxicity
Endocrine disruption
Galaxolide
Tonalide
Transcriptional effects
Biomarkers
topic Neurotoxicity
Endocrine disruption
Galaxolide
Tonalide
Transcriptional effects
Biomarkers
description Galaxolide (HHCB) and tonalide (AHTN) are polycyclic musk compounds (PMCs) used in household and personal care products that have been included on the list as emerging contaminants of environmental concern due to their ubiquity in aquatic and terrestrial environments. There still exists a dearth of information on the neurotoxicity and endocrine disrupting effects of these contaminants, especially for marine and estuarine species. Here, we assessed the neuroendocrine effects of HHCB and AHTN using adult clams, Ruditapes philippinarum, and yolk-sac larvae of sheepshead minnow, Cyprinodon variegatus. The clams were treated with concentrations (0.005–50 μg/L) of each compound for 21 days. Meanwhile, sheepshead minnow larvae were exposed to 0.5, 5 and 50 μg/L of HHCB and AHTN for 3 days. Enzyme activities related to neurotoxicity (acetylcholinesterase - AChE), neuroendocrine function (cyclooxygenase - COX), and energy reserves (total lipids - TL) were assessed in R. philippinarum. Gene expression levels of cyp19 and vtg1 were measured in C. variegatus using qPCR. Our results indicated induction of AChE and COX in the clams exposed to HHCB while AHTN exposure significantly inhibited AChE and COX. Gene expression of cyp19 and vtg1 in yolk-sac C. variegatus larvae exposed to 50 μg/L AHTN was significantly downregulated versus the control. The results of this study demonstrate that HHCB and AHTN might pose neurotoxic and endocrine disrupting effects in coastal ecosystems.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/253541
url http://hdl.handle.net/10261/253541
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//RYC-2017-22324
http://dx.doi.org/10.1016/j.envres.2021.110960
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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