A novel TAp73‐inhibitory compound counteracts stemness features of glioblastoma stem cells
[En] Glioblastoma (GB) is the most common and fatal type of primary malignant brain tumor for which effective therapeutics are still lacking. GB stem cells, with tumor-initiating and self-renewal capacity, are mostly responsible for GB malignancy, representing a crucial target for therapies. The TP7...
| Autores: | , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/23555 |
| Acesso em linha: | https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13694 https://hdl.handle.net/10612/23555 |
| Access Level: | acceso abierto |
| Palavra-chave: | Biología Biotecnología Genética Glioblastoma Glioblastoma stem cells TAp73 Stemness signature Natural compound 3109.02 Genética 2407 Biología Celular 24 Ciencias de la Vida 240701 Cultivo Celular 2409 Genética 240902 Ingeniería Genética 2415 Biología Molecular 320713 Oncología |
| Resumo: | [En] Glioblastoma (GB) is the most common and fatal type of primary malignant brain tumor for which effective therapeutics are still lacking. GB stem cells, with tumor-initiating and self-renewal capacity, are mostly responsible for GB malignancy, representing a crucial target for therapies. The TP73 gene, which is highly expressed in GB, gives rise to the TAp73 isoform, a pleiotropic protein that regulates neural stem cell biology; however, its role in cancer has been highly controversial. We inactivated TP73 in human GB stem cells and revealed that TAp73 is required for their stemness potential, acting as a regulator of the transcriptional stemness signatures, highlighting TAp73 as a possible therapeutic target. As proof of concept, we identified a novel natural compound with TAp73-inhibitory capacity, which was highly effective against GB stem cells. The treatment reduced GB stem cell-invasion capacity and stem features, at least in part by TAp73 repression. Our data are consistent with a novel paradigm in which hijacking of p73-regulated neurodevelopmental programs, including neural stemness, might sustain tumor progression, pointing out TAp73 as a therapeutic strategy for GB. |
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