Competing elastic and viscous gradients determine directional cell migration.

Cell migration regulates central life processes including embryonic development, tissue regeneration, and tumor invasion. To establish the direction of migration, cells follow exogenous cues. Durotaxis, the directed cell migration towards elastic stiffness gradients, is the classical example of mech...

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Detalles Bibliográficos
Autores: Saez, Pablo, Shirke, Pallavi U, Seth, Jyoti R, Alegre-Cebollada, Jorge, Majumder, Abhijit
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26211
Acceso en línea:https://hdl.handle.net/20.500.12105/26211
Access Level:acceso abierto
Palabra clave:Active gel models
Cell adhesion
Clutch model
Durotaxis
Mechanotransduction
Viscotaxis
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spelling Competing elastic and viscous gradients determine directional cell migration.Saez, PabloShirke, Pallavi USeth, Jyoti RAlegre-Cebollada, JorgeMajumder, AbhijitActive gel modelsCell adhesionClutch modelDurotaxisMechanotransductionViscotaxisCell migration regulates central life processes including embryonic development, tissue regeneration, and tumor invasion. To establish the direction of migration, cells follow exogenous cues. Durotaxis, the directed cell migration towards elastic stiffness gradients, is the classical example of mechanical taxis. However, whether gradients of the relaxation properties in the extracellular matrix may also induce tactic responses (viscotaxis) is not well understood. Moreover, whether and how durotaxis and viscotaxis interact with each other has never been investigated. Here, we integrate clutch models for cell adhesions with an active gel theory of cell migration to reveal the mechanisms that govern viscotaxis. We show that viscotaxis is enabled by an asymmetric expression of cell adhesions that further polarize the intracellular motility forces to establish the cell front, similar to durotaxis. More importantly, when both relaxation and elastic gradients coexist, durotaxis appears more efficient in controlling directed cell migration, which we confirm with experimental results. However, the presence of opposing relaxation gradients to an elastic one can arrest or shift the migration direction. Our model rationalizes for the first time the mechanisms that govern viscotaxis and its competition with durotaxis through a mathematical model.ElsevierMinisterio de Ciencia, Innovación y Universidades (España)Fundación ProCNICMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)20252025-01-3020242024-12-1720242024-12-17research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12105/26211reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PID2019-11094GB-100 Not availableES MICIU AEI 501100011033ES CEX2020-001041-S Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/262112026-06-12T12:43:37Z
dc.title.none.fl_str_mv Competing elastic and viscous gradients determine directional cell migration.
title Competing elastic and viscous gradients determine directional cell migration.
spellingShingle Competing elastic and viscous gradients determine directional cell migration.
Saez, Pablo
Active gel models
Cell adhesion
Clutch model
Durotaxis
Mechanotransduction
Viscotaxis
title_short Competing elastic and viscous gradients determine directional cell migration.
title_full Competing elastic and viscous gradients determine directional cell migration.
title_fullStr Competing elastic and viscous gradients determine directional cell migration.
title_full_unstemmed Competing elastic and viscous gradients determine directional cell migration.
title_sort Competing elastic and viscous gradients determine directional cell migration.
dc.creator.none.fl_str_mv Saez, Pablo
Shirke, Pallavi U
Seth, Jyoti R
Alegre-Cebollada, Jorge
Majumder, Abhijit
author Saez, Pablo
author_facet Saez, Pablo
Shirke, Pallavi U
Seth, Jyoti R
Alegre-Cebollada, Jorge
Majumder, Abhijit
author_role author
author2 Shirke, Pallavi U
Seth, Jyoti R
Alegre-Cebollada, Jorge
Majumder, Abhijit
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Fundación ProCNIC
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
dc.subject.none.fl_str_mv Active gel models
Cell adhesion
Clutch model
Durotaxis
Mechanotransduction
Viscotaxis
topic Active gel models
Cell adhesion
Clutch model
Durotaxis
Mechanotransduction
Viscotaxis
description Cell migration regulates central life processes including embryonic development, tissue regeneration, and tumor invasion. To establish the direction of migration, cells follow exogenous cues. Durotaxis, the directed cell migration towards elastic stiffness gradients, is the classical example of mechanical taxis. However, whether gradients of the relaxation properties in the extracellular matrix may also induce tactic responses (viscotaxis) is not well understood. Moreover, whether and how durotaxis and viscotaxis interact with each other has never been investigated. Here, we integrate clutch models for cell adhesions with an active gel theory of cell migration to reveal the mechanisms that govern viscotaxis. We show that viscotaxis is enabled by an asymmetric expression of cell adhesions that further polarize the intracellular motility forces to establish the cell front, similar to durotaxis. More importantly, when both relaxation and elastic gradients coexist, durotaxis appears more efficient in controlling directed cell migration, which we confirm with experimental results. However, the presence of opposing relaxation gradients to an elastic one can arrest or shift the migration direction. Our model rationalizes for the first time the mechanisms that govern viscotaxis and its competition with durotaxis through a mathematical model.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-12-17
2024
2024-12-17
2025
2025-01-30
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/26211
url https://hdl.handle.net/20.500.12105/26211
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PID2019-11094GB-100 Not available
ES MICIU AEI 501100011033
ES CEX2020-001041-S Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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