Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.

Gene expression profiling studies could be a valuable tool in identifying the specific genes and pathways involved in the mechanism of action of clozapine, leading to a better understanding of the molecular biology underlying treatment-resistant schizophrenia (TRS). We aimed to identify the co-expre...

Descripción completa

Detalles Bibliográficos
Autores: Prohens Coll, Llucia, Rodríguez Ferret, Natalia, Gonzalez Segura, Àlex, Martínez Pinteño, Albert, Olivares Berjaga, David, Martínez Martín, Irene, Mezquida Mateos, Gisela, Santas Martín, Jon A., Morentín, Benito, Meana, J. Javier, Callado, Luis F., Gassó Astorga, Patricia, Rivero Calera, Guadalupe, Mas Herrero, Sergi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/227709
Acceso en línea:https://hdl.handle.net/2445/227709
Access Level:acceso abierto
Palabra clave:Esquizofrènia
Farmacologia
Expressió gènica
Schizophrenia
Pharmacology
Gene expression
id ES_91aab1e92d4e00f1bbe919fd09ae650f
oai_identifier_str oai:diposit.ub.edu:2445/227709
network_acronym_str ES
network_name_str España
repository_id_str
spelling Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.Prohens Coll, LluciaRodríguez Ferret, Natalia Gonzalez Segura, ÀlexMartínez Pinteño, AlbertOlivares Berjaga, DavidMartínez Martín, IreneMezquida Mateos, GiselaSantas Martín, Jon A.Morentín, BenitoMeana, J. JavierCallado, Luis F.Gassó Astorga, PatriciaRivero Calera, GuadalupeMas Herrero, SergiEsquizofrèniaFarmacologiaExpressió gènicaSchizophreniaPharmacologyGene expressionGene expression profiling studies could be a valuable tool in identifying the specific genes and pathways involved in the mechanism of action of clozapine, leading to a better understanding of the molecular biology underlying treatment-resistant schizophrenia (TRS). We aimed to identify the co-expressed modules that reflect the genetic differences between clozapine-treated and non-clozapine-treated patients with schizophrenia as a proxy of TRS. Gene expression of DLPFC samples from 26 subjects with schizophrenia (13 clozapine treated and 13 non-clozapine treated) were analyzed using Clariom S Human Array. Weighted gene coexpression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its association with clozapine treatment. As a result of our analysis of the gene co-expression architecture in the DLPFC, among the 13 modules identified, one module (green) was significantly associated with clozapine treatment (p = 3.7 × 10−2). This module was significantly enriched in astrocyte markers (5.7 × 10−29) and genes involved in the polygenic architecture of TRS (1.6 × 10−2). This finding provides cell type-specific associations that could help in the interpretation of the neurobiological basis of TRS. A better understanding of the specific DLPFC cell types involved in clozapine treatment will contribute to the study of potential pathways and ultimately help improve psychiatric classification tools in personalized medicine.Nature Publishing Group2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/227709Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41398-025-03658-zTranslational Psychiatry, 2025, vol. 15, num.1https://doi.org/10.1038/s41398-025-03658-zcc-by-nc-nd (c) Prohens, L. et al., 2025http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2277092026-05-27T06:46:51Z
dc.title.none.fl_str_mv Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
title Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
spellingShingle Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
Prohens Coll, Llucia
Esquizofrènia
Farmacologia
Expressió gènica
Schizophrenia
Pharmacology
Gene expression
title_short Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
title_full Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
title_fullStr Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
title_full_unstemmed Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
title_sort Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
dc.creator.none.fl_str_mv Prohens Coll, Llucia
Rodríguez Ferret, Natalia
Gonzalez Segura, Àlex
Martínez Pinteño, Albert
Olivares Berjaga, David
Martínez Martín, Irene
Mezquida Mateos, Gisela
Santas Martín, Jon A.
Morentín, Benito
Meana, J. Javier
Callado, Luis F.
Gassó Astorga, Patricia
Rivero Calera, Guadalupe
Mas Herrero, Sergi
author Prohens Coll, Llucia
author_facet Prohens Coll, Llucia
Rodríguez Ferret, Natalia
Gonzalez Segura, Àlex
Martínez Pinteño, Albert
Olivares Berjaga, David
Martínez Martín, Irene
Mezquida Mateos, Gisela
Santas Martín, Jon A.
Morentín, Benito
Meana, J. Javier
Callado, Luis F.
Gassó Astorga, Patricia
Rivero Calera, Guadalupe
Mas Herrero, Sergi
author_role author
author2 Rodríguez Ferret, Natalia
Gonzalez Segura, Àlex
Martínez Pinteño, Albert
Olivares Berjaga, David
Martínez Martín, Irene
Mezquida Mateos, Gisela
Santas Martín, Jon A.
Morentín, Benito
Meana, J. Javier
Callado, Luis F.
Gassó Astorga, Patricia
Rivero Calera, Guadalupe
Mas Herrero, Sergi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esquizofrènia
Farmacologia
Expressió gènica
Schizophrenia
Pharmacology
Gene expression
topic Esquizofrènia
Farmacologia
Expressió gènica
Schizophrenia
Pharmacology
Gene expression
description Gene expression profiling studies could be a valuable tool in identifying the specific genes and pathways involved in the mechanism of action of clozapine, leading to a better understanding of the molecular biology underlying treatment-resistant schizophrenia (TRS). We aimed to identify the co-expressed modules that reflect the genetic differences between clozapine-treated and non-clozapine-treated patients with schizophrenia as a proxy of TRS. Gene expression of DLPFC samples from 26 subjects with schizophrenia (13 clozapine treated and 13 non-clozapine treated) were analyzed using Clariom S Human Array. Weighted gene coexpression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its association with clozapine treatment. As a result of our analysis of the gene co-expression architecture in the DLPFC, among the 13 modules identified, one module (green) was significantly associated with clozapine treatment (p = 3.7 × 10−2). This module was significantly enriched in astrocyte markers (5.7 × 10−29) and genes involved in the polygenic architecture of TRS (1.6 × 10−2). This finding provides cell type-specific associations that could help in the interpretation of the neurobiological basis of TRS. A better understanding of the specific DLPFC cell types involved in clozapine treatment will contribute to the study of potential pathways and ultimately help improve psychiatric classification tools in personalized medicine.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/227709
url https://hdl.handle.net/2445/227709
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41398-025-03658-z
Translational Psychiatry, 2025, vol. 15, num.1
https://doi.org/10.1038/s41398-025-03658-z
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Prohens, L. et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Prohens, L. et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413409078902784
score 15,812429

Similares en LA Referencia