NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast

22 páginas, 8 figuras.

Detalles Bibliográficos
Autores: Jiménez-Hidalgo, María, Santos-Ocaña, Carlos, Padilla, Sergio, Villalba, José M., López-Lluch, Guillermo, Martín-Montalvo, Alejandro, Minor, Robin K., Sinclair, David A., Cabo, Rafael de, Navas, Plácido
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/40151
Acceso en línea:http://hdl.handle.net/10261/40151
Access Level:acceso abierto
Palabra clave:Chronological lifespan
Coenzyme Q
Coencyme Q reductase
Dietary restriction
NQR1
Plasma membrane
Replicative lifespan
Cell aging
Electron transport complex
Energy metabolism
Ethanol
Histone deacetylases
Saccharomyces cerevisiae
Sirtuins
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oai_identifier_str oai:digital.csic.es:10261/40151
network_acronym_str ES
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repository_id_str
spelling NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeastJiménez-Hidalgo, MaríaSantos-Ocaña, CarlosPadilla, SergioVillalba, José M.López-Lluch, GuillermoMartín-Montalvo, AlejandroMinor, Robin K.Sinclair, David A.Cabo, Rafael deNavas, PlácidoChronological lifespanCoenzyme QCoencyme Q reductaseDietary restrictionNQR1Plasma membraneReplicative lifespanCell agingElectron transport complexEnergy metabolismEthanolHistone deacetylasesSaccharomyces cerevisiaeSirtuins22 páginas, 8 figuras.The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals.The work was supported by the Spanish Ministerio de Ciencia y Tecnología, Grant BFU2005-03017/BMC, by APP2E04053 Grant of the Universidad Pablo de Olavide, and in part by the Intramural Research Program of the National Institute on Aging, National Institutes of Health.Blackwell Publishing201120112009info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/40151reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1111/j.1474-9726.2009.00461.xinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/401512026-05-22T06:33:51Z
dc.title.none.fl_str_mv NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
title NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
spellingShingle NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
Jiménez-Hidalgo, María
Chronological lifespan
Coenzyme Q
Coencyme Q reductase
Dietary restriction
NQR1
Plasma membrane
Replicative lifespan
Cell aging
Electron transport complex
Energy metabolism
Ethanol
Histone deacetylases
Saccharomyces cerevisiae
Sirtuins
title_short NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
title_full NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
title_fullStr NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
title_full_unstemmed NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
title_sort NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
dc.creator.none.fl_str_mv Jiménez-Hidalgo, María
Santos-Ocaña, Carlos
Padilla, Sergio
Villalba, José M.
López-Lluch, Guillermo
Martín-Montalvo, Alejandro
Minor, Robin K.
Sinclair, David A.
Cabo, Rafael de
Navas, Plácido
author Jiménez-Hidalgo, María
author_facet Jiménez-Hidalgo, María
Santos-Ocaña, Carlos
Padilla, Sergio
Villalba, José M.
López-Lluch, Guillermo
Martín-Montalvo, Alejandro
Minor, Robin K.
Sinclair, David A.
Cabo, Rafael de
Navas, Plácido
author_role author
author2 Santos-Ocaña, Carlos
Padilla, Sergio
Villalba, José M.
López-Lluch, Guillermo
Martín-Montalvo, Alejandro
Minor, Robin K.
Sinclair, David A.
Cabo, Rafael de
Navas, Plácido
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chronological lifespan
Coenzyme Q
Coencyme Q reductase
Dietary restriction
NQR1
Plasma membrane
Replicative lifespan
Cell aging
Electron transport complex
Energy metabolism
Ethanol
Histone deacetylases
Saccharomyces cerevisiae
Sirtuins
topic Chronological lifespan
Coenzyme Q
Coencyme Q reductase
Dietary restriction
NQR1
Plasma membrane
Replicative lifespan
Cell aging
Electron transport complex
Energy metabolism
Ethanol
Histone deacetylases
Saccharomyces cerevisiae
Sirtuins
description 22 páginas, 8 figuras.
publishDate 2009
dc.date.none.fl_str_mv 2009
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/40151
url http://hdl.handle.net/10261/40151
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1111/j.1474-9726.2009.00461.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413393619746816
score 15,812455

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