Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model

Intrauterine growth restriction (IUGR) refers to poor growth of a fetus during pregnancy due to deficient maternal nutrition or oxygen supply. Supplementation of a mother's diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of IUGR. In t...

Descripción completa

Detalles Bibliográficos
Autores: Yeste, Natalia|||0000-0003-2471-2064, Gomez, Nestor|||0000-0002-1348-2737, Vázquez-Gómez, Marta|||0000-0002-8916-2086, García-Contreras, Consolación|||0000-0003-4624-2585, Pumarola i Batlle, Martí|||0000-0002-0935-7941, Gonzalez-Bulnes, Antonio|||0000-0002-0917-4475, Bassols Teixidó, Anna Maria|||0000-0003-4213-2274
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:263030
Acceso en línea:https://ddd.uab.cat/record/263030
https://dx.doi.org/urn:doi:10.3390/antiox10101505
Access Level:acceso abierto
Palabra clave:Hydroxytyrosol
Neurotransmitters
Intrauterine growth restriction
Hippocampus
Brain
Pig
id ES_916bfacd41d1a856d4db118b6680a2f2
oai_identifier_str oai:ddd.uab.cat:263030
network_acronym_str ES
network_name_str España
repository_id_str
spelling Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig ModelYeste, Natalia|||0000-0003-2471-2064Gomez, Nestor|||0000-0002-1348-2737Vázquez-Gómez, Marta|||0000-0002-8916-2086García-Contreras, Consolación|||0000-0003-4624-2585Pumarola i Batlle, Martí|||0000-0002-0935-7941Gonzalez-Bulnes, Antonio|||0000-0002-0917-4475Bassols Teixidó, Anna Maria|||0000-0003-4213-2274HydroxytyrosolNeurotransmittersIntrauterine growth restrictionHippocampusBrainPigIntrauterine growth restriction (IUGR) refers to poor growth of a fetus during pregnancy due to deficient maternal nutrition or oxygen supply. Supplementation of a mother's diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of IUGR. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of the total gestational period), and fetuses were sampled at day 100 of gestation. Fetuses were classified as normal body weight (NBW) or low body weight (LBW) as a consequence of IUGR, constituting four groups: NBW-Control, NBW-HTX, LBW-Control, and LBW-HTX. The brain was removed, and the hippocampus, amygdala, and prefrontal cortex were rapidly dissected. Neuronal markers were studied by immunohistochemistry, and a decrease in the number of mature neurons in the hippocampal Cornu Ammonis subfield 1 (CA1) and the Dentate Gyrus (DG) regions was observed in LBW fetuses together with a higher number of immature neurons and other alterations in neuronal morphology. Furthermore, IUGR conditions altered the neurotransmitter (NT) profile, since an increase in the serotonin (5-HT) pathway was observed in LBW fetuses. Supplementation with HTX was able to reverse the morphological and neurochemical changes, leading both characteristics to values similar to those of NBW fetuses. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttps://ddd.uab.cat/record/263030https://dx.doi.org/urn:doi:10.3390/antiox10101505reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-79321-C2-1-RMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FPU17/01881Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU14/01285Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 AGL2013-48121-C3-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 AGL2015-68463-C2-2-Popen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2630302026-06-06T12:50:31Z
dc.title.none.fl_str_mv Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
spellingShingle Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
Yeste, Natalia|||0000-0003-2471-2064
Hydroxytyrosol
Neurotransmitters
Intrauterine growth restriction
Hippocampus
Brain
Pig
title_short Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_full Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_fullStr Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_full_unstemmed Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_sort Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
dc.creator.none.fl_str_mv Yeste, Natalia|||0000-0003-2471-2064
Gomez, Nestor|||0000-0002-1348-2737
Vázquez-Gómez, Marta|||0000-0002-8916-2086
García-Contreras, Consolación|||0000-0003-4624-2585
Pumarola i Batlle, Martí|||0000-0002-0935-7941
Gonzalez-Bulnes, Antonio|||0000-0002-0917-4475
Bassols Teixidó, Anna Maria|||0000-0003-4213-2274
author Yeste, Natalia|||0000-0003-2471-2064
author_facet Yeste, Natalia|||0000-0003-2471-2064
Gomez, Nestor|||0000-0002-1348-2737
Vázquez-Gómez, Marta|||0000-0002-8916-2086
García-Contreras, Consolación|||0000-0003-4624-2585
Pumarola i Batlle, Martí|||0000-0002-0935-7941
Gonzalez-Bulnes, Antonio|||0000-0002-0917-4475
Bassols Teixidó, Anna Maria|||0000-0003-4213-2274
author_role author
author2 Gomez, Nestor|||0000-0002-1348-2737
Vázquez-Gómez, Marta|||0000-0002-8916-2086
García-Contreras, Consolación|||0000-0003-4624-2585
Pumarola i Batlle, Martí|||0000-0002-0935-7941
Gonzalez-Bulnes, Antonio|||0000-0002-0917-4475
Bassols Teixidó, Anna Maria|||0000-0003-4213-2274
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Hydroxytyrosol
Neurotransmitters
Intrauterine growth restriction
Hippocampus
Brain
Pig
topic Hydroxytyrosol
Neurotransmitters
Intrauterine growth restriction
Hippocampus
Brain
Pig
description Intrauterine growth restriction (IUGR) refers to poor growth of a fetus during pregnancy due to deficient maternal nutrition or oxygen supply. Supplementation of a mother's diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of IUGR. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of the total gestational period), and fetuses were sampled at day 100 of gestation. Fetuses were classified as normal body weight (NBW) or low body weight (LBW) as a consequence of IUGR, constituting four groups: NBW-Control, NBW-HTX, LBW-Control, and LBW-HTX. The brain was removed, and the hippocampus, amygdala, and prefrontal cortex were rapidly dissected. Neuronal markers were studied by immunohistochemistry, and a decrease in the number of mature neurons in the hippocampal Cornu Ammonis subfield 1 (CA1) and the Dentate Gyrus (DG) regions was observed in LBW fetuses together with a higher number of immature neurons and other alterations in neuronal morphology. Furthermore, IUGR conditions altered the neurotransmitter (NT) profile, since an increase in the serotonin (5-HT) pathway was observed in LBW fetuses. Supplementation with HTX was able to reverse the morphological and neurochemical changes, leading both characteristics to values similar to those of NBW fetuses.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/263030
https://dx.doi.org/urn:doi:10.3390/antiox10101505
url https://ddd.uab.cat/record/263030
https://dx.doi.org/urn:doi:10.3390/antiox10101505
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-79321-C2-1-R
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FPU17/01881
Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU14/01285
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 AGL2013-48121-C3-R
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 AGL2015-68463-C2-2-P
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413389122404352
score 15,301603

Similares en LA Referencia