Effects of phage-based treatments against an OXA-48-producing Klebsiella pneumoniae isolate in simulated human gut microbiomes

[Background] Carbapenem-resistant K. pneumoniae (CRKP) is one of the most prevalent antimicrobial-resistant pathogens, primarily causing nosocomial infections. These bacteria often colonize the gut microbiota, and their carriage is an important risk factor for later infection. Phages are an emerging...

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Detalles Bibliográficos
Autores: Ferriol-González, Celia, Hernanz-Grimalt, Ana, Valdivia, Carlos, García-Cobos, Silvia, Heredia, Ana, García-Hernández, Jorge, Andrés, Ana, Domingo-Calap, Pilar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::26a3ce6ed19c8b20229556fc2b0f1c43
Acceso en línea:http://hdl.handle.net/10261/426301
Access Level:acceso abierto
Palabra clave:Bacteriophage
SHIME
Gut microbiota
Phage therapy
Klebsiella pneumoniae
OXA-48
Descripción
Sumario:[Background] Carbapenem-resistant K. pneumoniae (CRKP) is one of the most prevalent antimicrobial-resistant pathogens, primarily causing nosocomial infections. These bacteria often colonize the gut microbiota, and their carriage is an important risk factor for later infection. Phages are an emerging alternative against antimicrobial-resistant bacteria causing infections, but their effect on the microbiota is still poorly understood.

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