The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis

Purpose: Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic biomarker of disability progression in multiple sclerosis (MS). However, SWI is not routinely performed in clinical practice. The objective of this study is to define a n...

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Autores: Naval Baudin, Pablo, Pons Escoda, Albert, Castillo-Pinar, Albert, Martínez-Zalacaín, Ignacio, Arroyo Pereiro, Pablo, Flores-Casaperalta, Susanie, Garay Buitron, Francis, Calvo Piñero, Natàlia, Martínez Yélamos, Antonio, Cos Domingo, Mònica, Martínez Yélamos, Sergio, Majós Torró, Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/214197
Acceso en línea:https://hdl.handle.net/2445/214197
Access Level:acceso abierto
Palabra clave:Esclerosi múltiple
Inflamació
Imatges per ressonància magnètica
Multiple sclerosis
Inflammation
Magnetic resonance imaging
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spelling The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosisNaval Baudin, PabloPons Escoda, AlbertCastillo-Pinar, AlbertMartínez-Zalacaín, IgnacioArroyo Pereiro, PabloFlores-Casaperalta, SusanieGaray Buitron, FrancisCalvo Piñero, NatàliaMartínez Yélamos, AntonioCos Domingo, MònicaMartínez Yélamos, SergioMajós Torró, CarlosEsclerosi múltipleInflamacióImatges per ressonància magnèticaMultiple sclerosisInflammationMagnetic resonance imagingPurpose: Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic biomarker of disability progression in multiple sclerosis (MS). However, SWI is not routinely performed in clinical practice. The objective of this study is to define a novel imaging sign, the T1-dark rim, identifiable in a standard 3DT1 gradient-echo inversion-recovery sequence, such as 3D T1 turbo field echo (3DT1FE) and explore its performance as a SWI surrogate to define PRLs. Methods: This observational cross-sectional study analyzed MS patients who underwent 3T magnetic resonance imaging (MRI) including 3DT1TFE and SWI. Rim lesions were evaluated in 3DT1TFE, processed SWI, and SWI phase and categorized as true positive, false positive, or false negative based on the value of the T1-dark rim in predicting SWI phase PRLs. Sensitivity and positive predictive values of the T1-dark rim for detecting PRLs were calculated. Results: Overall, 80 rim lesions were identified in 63 patients (60 in the SWI phase and 78 in 3DT1TFE; 58 true positives, 20 false positives, and two false negatives). The T1-dark rim demonstrated 97% sensitivity and 74% positive predictive value for detecting PRLs. More PRLs were detected in the SWI phase than in processed SWI (60 and 57, respectively). Conclusion: The T1-dark rim sign is a promising and accessible novel imaging marker to detect PRLs whose high sensitivity may enable earlier detection of chronic active lesions to guide MS treatment escalation. The relevance of T1-dark rim lesions that are negative on SWI opens up a new field for analysis.Elsevier B.V.2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/214197Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.ejrad.2024.111358European Journal of Radiology, 2024, vol. 173https://doi.org/10.1016/j.ejrad.2024.111358cc-by-nc-nd (c) Naval Baudin, Pablo et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2141972026-05-27T06:46:51Z
dc.title.none.fl_str_mv The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
title The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
spellingShingle The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
Naval Baudin, Pablo
Esclerosi múltiple
Inflamació
Imatges per ressonància magnètica
Multiple sclerosis
Inflammation
Magnetic resonance imaging
title_short The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
title_full The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
title_fullStr The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
title_full_unstemmed The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
title_sort The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
dc.creator.none.fl_str_mv Naval Baudin, Pablo
Pons Escoda, Albert
Castillo-Pinar, Albert
Martínez-Zalacaín, Ignacio
Arroyo Pereiro, Pablo
Flores-Casaperalta, Susanie
Garay Buitron, Francis
Calvo Piñero, Natàlia
Martínez Yélamos, Antonio
Cos Domingo, Mònica
Martínez Yélamos, Sergio
Majós Torró, Carlos
author Naval Baudin, Pablo
author_facet Naval Baudin, Pablo
Pons Escoda, Albert
Castillo-Pinar, Albert
Martínez-Zalacaín, Ignacio
Arroyo Pereiro, Pablo
Flores-Casaperalta, Susanie
Garay Buitron, Francis
Calvo Piñero, Natàlia
Martínez Yélamos, Antonio
Cos Domingo, Mònica
Martínez Yélamos, Sergio
Majós Torró, Carlos
author_role author
author2 Pons Escoda, Albert
Castillo-Pinar, Albert
Martínez-Zalacaín, Ignacio
Arroyo Pereiro, Pablo
Flores-Casaperalta, Susanie
Garay Buitron, Francis
Calvo Piñero, Natàlia
Martínez Yélamos, Antonio
Cos Domingo, Mònica
Martínez Yélamos, Sergio
Majós Torró, Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esclerosi múltiple
Inflamació
Imatges per ressonància magnètica
Multiple sclerosis
Inflammation
Magnetic resonance imaging
topic Esclerosi múltiple
Inflamació
Imatges per ressonància magnètica
Multiple sclerosis
Inflammation
Magnetic resonance imaging
description Purpose: Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic biomarker of disability progression in multiple sclerosis (MS). However, SWI is not routinely performed in clinical practice. The objective of this study is to define a novel imaging sign, the T1-dark rim, identifiable in a standard 3DT1 gradient-echo inversion-recovery sequence, such as 3D T1 turbo field echo (3DT1FE) and explore its performance as a SWI surrogate to define PRLs. Methods: This observational cross-sectional study analyzed MS patients who underwent 3T magnetic resonance imaging (MRI) including 3DT1TFE and SWI. Rim lesions were evaluated in 3DT1TFE, processed SWI, and SWI phase and categorized as true positive, false positive, or false negative based on the value of the T1-dark rim in predicting SWI phase PRLs. Sensitivity and positive predictive values of the T1-dark rim for detecting PRLs were calculated. Results: Overall, 80 rim lesions were identified in 63 patients (60 in the SWI phase and 78 in 3DT1TFE; 58 true positives, 20 false positives, and two false negatives). The T1-dark rim demonstrated 97% sensitivity and 74% positive predictive value for detecting PRLs. More PRLs were detected in the SWI phase than in processed SWI (60 and 57, respectively). Conclusion: The T1-dark rim sign is a promising and accessible novel imaging marker to detect PRLs whose high sensitivity may enable earlier detection of chronic active lesions to guide MS treatment escalation. The relevance of T1-dark rim lesions that are negative on SWI opens up a new field for analysis.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214197
url https://hdl.handle.net/2445/214197
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ejrad.2024.111358
European Journal of Radiology, 2024, vol. 173
https://doi.org/10.1016/j.ejrad.2024.111358
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Naval Baudin, Pablo et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Naval Baudin, Pablo et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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