Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters

The use of protons and heavy ions for the treatment of tumors is increasing since it provides a better relative biological effectiveness (RBE) than traditional radiotherapy. Accurate knowledge of the energy deposition at submicrometric scales is paramount for RBE characterization. This paper shows t...

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Authors: Prieto-Pena, Juan, Gomez, Faustino, Fleta, Celeste, Guardiola, Consuelo, Pellegrini, Giulio, Donetti, Marco, Giordanengo, Simona, Gonzalez-Castano, Diego M., Pardo-Montero, Juan
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/376630
Online Access:http://hdl.handle.net/10261/376630
https://api.elsevier.com/content/abstract/scopus_id/85069534701
Access Level:Open access
Keyword:Hadrontherapy | microdosimetry | silicon detectors
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spelling Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical MicrodosimetersPrieto-Pena, JuanGomez, FaustinoFleta, CelesteGuardiola, ConsueloPellegrini, GiulioDonetti, MarcoGiordanengo, SimonaGonzalez-Castano, Diego M.Pardo-Montero, JuanHadrontherapy | microdosimetry | silicon detectorsThe use of protons and heavy ions for the treatment of tumors is increasing since it provides a better relative biological effectiveness (RBE) than traditional radiotherapy. Accurate knowledge of the energy deposition at submicrometric scales is paramount for RBE characterization. This paper shows the latest version of the silicon cylindrical microdosimeter array developed by the Instituto de Microelectrónica de Barcelona, Centro Nacional de Microelectrónica (IMB-CNM, Spain). The detector consists of a matrix of 11 × 11 cylindrical sensitive unit cells with individual readout etched within the silicon substrate available in different diameters and pitches between detectors. The detector employed in this paper had a diameter of 15μ, a pitch of 200μ, and a thickness of 5.5μ. The detectors were tested in the clinical facilities of Fondazione Centro Nazionale di Adronterapia Oncologica (CNAO) (Pavia, Italy) employing a 12C pencil beam at a therapeutic beam fluence rate. Microdosimetric spectra of lineal energy were measured in different depths of polymethyl methacrylate (PMMA) up to the Bragg peak. Results were then compared with Monte Carlo simulations using the FLUKA particle transport code, showing an excellent agreement between experimental and simulated microdosimetric distributions even at the high fluence rates associated with clinical beams.Manuscript received May 7, 2019; accepted June 4, 2019. Date of publication June 6, 2019; date of current version July 16, 2019. The works of J. Prieto-Pena, F. Gómez, and D. M. González-Castaño were supported by the Spanish MINECO Project under Grant DPI2014-57645-R. The work of J. Prieto-Pena was supported by a Predoctoral Fundación Barrié Grant. The work of J. Pardo-Montero was supported by the Instituto de Salud Carlos III under Grant CPII17/00028, Grant PI17/01428, and Grant DTS17/00123.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Instituto de Salud Carlos IIIPrieto-Pena, Juan [0000-0001-5436-9266]Pardo-Montero, Juan [0000-0001-7990-3971]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/376630https://api.elsevier.com/content/abstract/scopus_id/85069534701reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//DPI2014-57645-Rinfo:eu-repo/grantAgreement/ISCIII/CPII17/00028info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/DTS17%2F00123info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01428IEEE Transactions on Nuclear Sciencehttps://ieeexplore.ieee.org/document/8732375/authors#authorsSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3766302026-05-22T06:33:51Z
dc.title.none.fl_str_mv Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
title Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
spellingShingle Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
Prieto-Pena, Juan
Hadrontherapy | microdosimetry | silicon detectors
title_short Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
title_full Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
title_fullStr Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
title_full_unstemmed Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
title_sort Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters
dc.creator.none.fl_str_mv Prieto-Pena, Juan
Gomez, Faustino
Fleta, Celeste
Guardiola, Consuelo
Pellegrini, Giulio
Donetti, Marco
Giordanengo, Simona
Gonzalez-Castano, Diego M.
Pardo-Montero, Juan
author Prieto-Pena, Juan
author_facet Prieto-Pena, Juan
Gomez, Faustino
Fleta, Celeste
Guardiola, Consuelo
Pellegrini, Giulio
Donetti, Marco
Giordanengo, Simona
Gonzalez-Castano, Diego M.
Pardo-Montero, Juan
author_role author
author2 Gomez, Faustino
Fleta, Celeste
Guardiola, Consuelo
Pellegrini, Giulio
Donetti, Marco
Giordanengo, Simona
Gonzalez-Castano, Diego M.
Pardo-Montero, Juan
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Instituto de Salud Carlos III
Prieto-Pena, Juan [0000-0001-5436-9266]
Pardo-Montero, Juan [0000-0001-7990-3971]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hadrontherapy | microdosimetry | silicon detectors
topic Hadrontherapy | microdosimetry | silicon detectors
description The use of protons and heavy ions for the treatment of tumors is increasing since it provides a better relative biological effectiveness (RBE) than traditional radiotherapy. Accurate knowledge of the energy deposition at submicrometric scales is paramount for RBE characterization. This paper shows the latest version of the silicon cylindrical microdosimeter array developed by the Instituto de Microelectrónica de Barcelona, Centro Nacional de Microelectrónica (IMB-CNM, Spain). The detector consists of a matrix of 11 × 11 cylindrical sensitive unit cells with individual readout etched within the silicon substrate available in different diameters and pitches between detectors. The detector employed in this paper had a diameter of 15μ, a pitch of 200μ, and a thickness of 5.5μ. The detectors were tested in the clinical facilities of Fondazione Centro Nazionale di Adronterapia Oncologica (CNAO) (Pavia, Italy) employing a 12C pencil beam at a therapeutic beam fluence rate. Microdosimetric spectra of lineal energy were measured in different depths of polymethyl methacrylate (PMMA) up to the Bragg peak. Results were then compared with Monte Carlo simulations using the FLUKA particle transport code, showing an excellent agreement between experimental and simulated microdosimetric distributions even at the high fluence rates associated with clinical beams.
publishDate 2019
dc.date.none.fl_str_mv 2019
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/376630
https://api.elsevier.com/content/abstract/scopus_id/85069534701
url http://hdl.handle.net/10261/376630
https://api.elsevier.com/content/abstract/scopus_id/85069534701
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//DPI2014-57645-R
info:eu-repo/grantAgreement/ISCIII/CPII17/00028
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/DTS17%2F00123
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01428
IEEE Transactions on Nuclear Science
https://ieeexplore.ieee.org/document/8732375/authors#authors
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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