Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.

The enumeration of circulating tumor cells (CTCs) in peripheral blood correlates with clinical outcome in castration-resistant prostate cancer (CRPC). We analyzed the molecular profiling of peripheral blood from 43 metastatic CRPC patients with known CTC content in order to identify genes that may b...

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Autores: Marín Aguilera, Mercedes, Reig Torras, Oscar, Lozano Salvatella, Juan José, Jiménez, Natalia, Garcia Recio, Susana, Erill, Nadina, Gaba, Lydia, Tagliapietra, Andrea, Ortega, Vanessa, Carrera, Gemma, Colomer, Anna, Gascón, Pere, Mellado González, Begoña
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/120274
Acceso en línea:https://hdl.handle.net/2445/120274
Access Level:acceso abierto
Palabra clave:Càncer de pròstata
Oncologia
Metàstasi
Prostate cancer
Oncology
Metastasis
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spelling Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.Marín Aguilera, MercedesReig Torras, OscarLozano Salvatella, Juan JoséJiménez, NataliaGarcia Recio, SusanaErill, NadinaGaba, LydiaTagliapietra, AndreaOrtega, VanessaCarrera, GemmaColomer, AnnaGascón, PereMellado González, BegoñaCàncer de pròstataOncologiaMetàstasiProstate cancerOncologyMetastasisThe enumeration of circulating tumor cells (CTCs) in peripheral blood correlates with clinical outcome in castration-resistant prostate cancer (CRPC). We analyzed the molecular profiling of peripheral blood from 43 metastatic CRPC patients with known CTC content in order to identify genes that may be related to prostate cancer progression. Global gene expression analysis identified the differential expression of 282 genes between samples with ≥5 CTCs vs <5 CTCs, 58.6% of which were previously described as over-expressed in prostate cancer (18.9% in primary tumors and 56.1% in metastasis). Those genes were involved in survival functions such as metabolism, signal transduction, gene expression, cell growth, death, and movement. The expression of selected genes was evaluated by quantitative RT-PCR. This analysis revealed a two-gene model (SELENBP1 and MMP9) with a high significant prognostic ability (HR 6; 95% CI 2.61 - 13.79; P<0.0001). The combination of the two-gene signature plus the CTCs count showed a higher prognostic ability than CTCs enumeration or gene expression alone (P<0.05). This study shows a gene expression profile in PBMNC associated with CTCs count and clinical outcome in metastatic CRPC, describing genes and pathways potentially associated with CRPC progression.Impact Journals2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/120274Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.18632/oncotarget.3550Oncotarget, 2015, vol. 6, num. 12, p. 10604-10616https://doi.org/10.18632/oncotarget.3550cc-by (c) Marín Aguilera, Mercedes et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1202742026-05-29T05:05:01Z
dc.title.none.fl_str_mv Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
title Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
spellingShingle Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
Marín Aguilera, Mercedes
Càncer de pròstata
Oncologia
Metàstasi
Prostate cancer
Oncology
Metastasis
title_short Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
title_full Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
title_fullStr Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
title_full_unstemmed Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
title_sort Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
dc.creator.none.fl_str_mv Marín Aguilera, Mercedes
Reig Torras, Oscar
Lozano Salvatella, Juan José
Jiménez, Natalia
Garcia Recio, Susana
Erill, Nadina
Gaba, Lydia
Tagliapietra, Andrea
Ortega, Vanessa
Carrera, Gemma
Colomer, Anna
Gascón, Pere
Mellado González, Begoña
author Marín Aguilera, Mercedes
author_facet Marín Aguilera, Mercedes
Reig Torras, Oscar
Lozano Salvatella, Juan José
Jiménez, Natalia
Garcia Recio, Susana
Erill, Nadina
Gaba, Lydia
Tagliapietra, Andrea
Ortega, Vanessa
Carrera, Gemma
Colomer, Anna
Gascón, Pere
Mellado González, Begoña
author_role author
author2 Reig Torras, Oscar
Lozano Salvatella, Juan José
Jiménez, Natalia
Garcia Recio, Susana
Erill, Nadina
Gaba, Lydia
Tagliapietra, Andrea
Ortega, Vanessa
Carrera, Gemma
Colomer, Anna
Gascón, Pere
Mellado González, Begoña
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de pròstata
Oncologia
Metàstasi
Prostate cancer
Oncology
Metastasis
topic Càncer de pròstata
Oncologia
Metàstasi
Prostate cancer
Oncology
Metastasis
description The enumeration of circulating tumor cells (CTCs) in peripheral blood correlates with clinical outcome in castration-resistant prostate cancer (CRPC). We analyzed the molecular profiling of peripheral blood from 43 metastatic CRPC patients with known CTC content in order to identify genes that may be related to prostate cancer progression. Global gene expression analysis identified the differential expression of 282 genes between samples with ≥5 CTCs vs <5 CTCs, 58.6% of which were previously described as over-expressed in prostate cancer (18.9% in primary tumors and 56.1% in metastasis). Those genes were involved in survival functions such as metabolism, signal transduction, gene expression, cell growth, death, and movement. The expression of selected genes was evaluated by quantitative RT-PCR. This analysis revealed a two-gene model (SELENBP1 and MMP9) with a high significant prognostic ability (HR 6; 95% CI 2.61 - 13.79; P<0.0001). The combination of the two-gene signature plus the CTCs count showed a higher prognostic ability than CTCs enumeration or gene expression alone (P<0.05). This study shows a gene expression profile in PBMNC associated with CTCs count and clinical outcome in metastatic CRPC, describing genes and pathways potentially associated with CRPC progression.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120274
url https://hdl.handle.net/2445/120274
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.3550
Oncotarget, 2015, vol. 6, num. 12, p. 10604-10616
https://doi.org/10.18632/oncotarget.3550
dc.rights.none.fl_str_mv cc-by (c) Marín Aguilera, Mercedes et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Marín Aguilera, Mercedes et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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