Guidelines and definitions for research on epithelial-mesenchymal transition

Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a cons...

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Detalles Bibliográficos
Autores: Yang, Jing, García de Herreros, Antonio, Sheng, Guojun, EMT International Association (TEMTIA)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/44966
Acceso en línea:http://hdl.handle.net/10230/44966
http://dx.doi.org/10.1038/s41580-020-0237-9
Access Level:acceso abierto
Palabra clave:Cèl·lules epitelials
Regulació cel·lular -- Guies
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spelling Guidelines and definitions for research on epithelial-mesenchymal transitionYang, JingGarcía de Herreros, AntonioSheng, GuojunEMT International Association (TEMTIA)Cèl·lules epitelialsRegulació cel·lular -- GuiesEpithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.Nature Research202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/44966http://dx.doi.org/10.1038/s41580-020-0237-9reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNature Reviews Molecular Cell Biology. 2020 Jun;21(6):341-52Copyright © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/449662026-05-29T05:05:01Z
dc.title.none.fl_str_mv Guidelines and definitions for research on epithelial-mesenchymal transition
title Guidelines and definitions for research on epithelial-mesenchymal transition
spellingShingle Guidelines and definitions for research on epithelial-mesenchymal transition
Yang, Jing
Cèl·lules epitelials
Regulació cel·lular -- Guies
title_short Guidelines and definitions for research on epithelial-mesenchymal transition
title_full Guidelines and definitions for research on epithelial-mesenchymal transition
title_fullStr Guidelines and definitions for research on epithelial-mesenchymal transition
title_full_unstemmed Guidelines and definitions for research on epithelial-mesenchymal transition
title_sort Guidelines and definitions for research on epithelial-mesenchymal transition
dc.creator.none.fl_str_mv Yang, Jing
García de Herreros, Antonio
Sheng, Guojun
EMT International Association (TEMTIA)
author Yang, Jing
author_facet Yang, Jing
García de Herreros, Antonio
Sheng, Guojun
EMT International Association (TEMTIA)
author_role author
author2 García de Herreros, Antonio
Sheng, Guojun
EMT International Association (TEMTIA)
author2_role author
author
author
dc.subject.none.fl_str_mv Cèl·lules epitelials
Regulació cel·lular -- Guies
topic Cèl·lules epitelials
Regulació cel·lular -- Guies
description Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/44966
http://dx.doi.org/10.1038/s41580-020-0237-9
url http://hdl.handle.net/10230/44966
http://dx.doi.org/10.1038/s41580-020-0237-9
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nature Reviews Molecular Cell Biology. 2020 Jun;21(6):341-52
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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