Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants

Xanthine oxidoreductase (XOR) is among the most-intensively studied enzymes known to participate in the consumption of oxygen in cells. However, it attracted the attention of researchers due its participation in free radical production in vivo, mainly through the production of superoxide radicals. I...

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Autores: Urarte Rodríguez, Estíbaliz, Esteban Terradillos, Raquel, Morán Juez, José Fernando, Bittner, Florian
Tipo de recurso: capítulo de libro
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/43220
Acceso en línea:https://hdl.handle.net/2454/43220
Access Level:acceso abierto
Palabra clave:Xanthine oxidoreductase
Enzymes
Superoxide radicals
Purine degradation
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spelling Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plantsUrarte Rodríguez, EstíbalizEsteban Terradillos, RaquelMorán Juez, José FernandoBittner, FlorianXanthine oxidoreductaseEnzymesSuperoxide radicalsPurine degradationXanthine oxidoreductase (XOR) is among the most-intensively studied enzymes known to participate in the consumption of oxygen in cells. However, it attracted the attention of researchers due its participation in free radical production in vivo, mainly through the production of superoxide radicals. In plants, XOR is a key enzyme in purine degradation where it catalyzes the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. Both reactions are accompanied by electron transfer to either NAD+ with simultaneous formation of NADH or to molecular oxygen, which results in formation of superoxides. Characterization of plant XOR mutants and isolated XOR proteins from various plant species provided evidence that the enzyme plays significant roles in plant growth, leaf senescence, fruit size, synthesis of nitrogen storage compounds, and plant-pathogen interactions. Moreover, the ability of XOR to carry out redox reactions as NADH oxidase and to produce reactive oxygen species and nitric oxide, together with a possible complementary role in abscisic acid synthesis have raised further attention on the importance of this enzyme. Based on these established and proposed functions, XOR is discussed as regulator of different processes of interest in plant biology and agriculture.The authors acknowledge the support of the research grants AGL2010-16167 to J.F.M. from the Spanish Ministry of Science and Innovation and Bi 1075/5-1 to F.B. by the Deutsche Forschungsgemeinschaft. R.E. received a JAE-Doctor grant from the Spanish Research Council (CSIC).SpringerIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua2014info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/43220reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/432202026-06-17T12:41:47Z
dc.title.none.fl_str_mv Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
title Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
spellingShingle Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
Urarte Rodríguez, Estíbaliz
Xanthine oxidoreductase
Enzymes
Superoxide radicals
Purine degradation
title_short Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
title_full Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
title_fullStr Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
title_full_unstemmed Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
title_sort Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants
dc.creator.none.fl_str_mv Urarte Rodríguez, Estíbaliz
Esteban Terradillos, Raquel
Morán Juez, José Fernando
Bittner, Florian
author Urarte Rodríguez, Estíbaliz
author_facet Urarte Rodríguez, Estíbaliz
Esteban Terradillos, Raquel
Morán Juez, José Fernando
Bittner, Florian
author_role author
author2 Esteban Terradillos, Raquel
Morán Juez, José Fernando
Bittner, Florian
author2_role author
author
author
dc.contributor.none.fl_str_mv IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
dc.subject.none.fl_str_mv Xanthine oxidoreductase
Enzymes
Superoxide radicals
Purine degradation
topic Xanthine oxidoreductase
Enzymes
Superoxide radicals
Purine degradation
description Xanthine oxidoreductase (XOR) is among the most-intensively studied enzymes known to participate in the consumption of oxygen in cells. However, it attracted the attention of researchers due its participation in free radical production in vivo, mainly through the production of superoxide radicals. In plants, XOR is a key enzyme in purine degradation where it catalyzes the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. Both reactions are accompanied by electron transfer to either NAD+ with simultaneous formation of NADH or to molecular oxygen, which results in formation of superoxides. Characterization of plant XOR mutants and isolated XOR proteins from various plant species provided evidence that the enzyme plays significant roles in plant growth, leaf senescence, fruit size, synthesis of nitrogen storage compounds, and plant-pathogen interactions. Moreover, the ability of XOR to carry out redox reactions as NADH oxidase and to produce reactive oxygen species and nitric oxide, together with a possible complementary role in abscisic acid synthesis have raised further attention on the importance of this enzyme. Based on these established and proposed functions, XOR is discussed as regulator of different processes of interest in plant biology and agriculture.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/acceptedVersion
format bookPart
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/43220
url https://hdl.handle.net/2454/43220
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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repository.mail.fl_str_mv
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