Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe

Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such...

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Autores: Rubió Casadevall, Jordi, Ciurana Montiel, Elna de, Puigdemont, Montserrat, Sanvisens, Arantza, Marruecos, Jordi, Miró, Josefina, Urban, Antoni, Palhua, Rosa Lisset, Martín-Romero, Ferran, Ortiz Duran, Maria Rosa, Marcos-Gragera, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/21758
Acceso en línea:http://hdl.handle.net/10256/21758
Access Level:acceso abierto
Palabra clave:Orofaringe -- Càncer
Oropharynx -- Cancer
Epidemiologia
Epidemiology
Papil·lomavirus
Papillomaviruses
Supervivència
Survival
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spelling Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern EuropeRubió Casadevall, JordiCiurana Montiel, Elna dePuigdemont, MontserratSanvisens, ArantzaMarruecos, JordiMiró, JosefinaUrban, AntoniPalhua, Rosa LissetMartín-Romero, FerranOrtiz Duran, Maria RosaMarcos-Gragera, RafaelOrofaringe -- CàncerOropharynx -- CancerEpidemiologiaEpidemiologyPapil·lomavirusPapillomavirusesSupervivènciaSurvivalIntroduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. Methods: We analyzed the epidemiology of OPC using the database from Girona’s population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997–1999, 2003–2005, 2009–2011, and 2016–2018. Results: Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016–2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Conclusions: Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPCMDPI (Multidisciplinary Digital Publishing Institute)2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/21758http://hdl.handle.net/10256/21758International Journal of Environmental Research and Public Health, 2022, vol. 19, núm. 8, p. 4802Articles publicats (D-CM)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.3390/ijerph19084802info:eu-repo/semantics/altIdentifier/issn/1661-7827info:eu-repo/semantics/altIdentifier/eissn/1660-4601Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/217582026-05-29T05:05:01Z
dc.title.none.fl_str_mv Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
title Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
spellingShingle Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
Rubió Casadevall, Jordi
Orofaringe -- Càncer
Oropharynx -- Cancer
Epidemiologia
Epidemiology
Papil·lomavirus
Papillomaviruses
Supervivència
Survival
title_short Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
title_full Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
title_fullStr Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
title_full_unstemmed Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
title_sort Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
dc.creator.none.fl_str_mv Rubió Casadevall, Jordi
Ciurana Montiel, Elna de
Puigdemont, Montserrat
Sanvisens, Arantza
Marruecos, Jordi
Miró, Josefina
Urban, Antoni
Palhua, Rosa Lisset
Martín-Romero, Ferran
Ortiz Duran, Maria Rosa
Marcos-Gragera, Rafael
author Rubió Casadevall, Jordi
author_facet Rubió Casadevall, Jordi
Ciurana Montiel, Elna de
Puigdemont, Montserrat
Sanvisens, Arantza
Marruecos, Jordi
Miró, Josefina
Urban, Antoni
Palhua, Rosa Lisset
Martín-Romero, Ferran
Ortiz Duran, Maria Rosa
Marcos-Gragera, Rafael
author_role author
author2 Ciurana Montiel, Elna de
Puigdemont, Montserrat
Sanvisens, Arantza
Marruecos, Jordi
Miró, Josefina
Urban, Antoni
Palhua, Rosa Lisset
Martín-Romero, Ferran
Ortiz Duran, Maria Rosa
Marcos-Gragera, Rafael
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Orofaringe -- Càncer
Oropharynx -- Cancer
Epidemiologia
Epidemiology
Papil·lomavirus
Papillomaviruses
Supervivència
Survival
topic Orofaringe -- Càncer
Oropharynx -- Cancer
Epidemiologia
Epidemiology
Papil·lomavirus
Papillomaviruses
Supervivència
Survival
description Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. Methods: We analyzed the epidemiology of OPC using the database from Girona’s population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997–1999, 2003–2005, 2009–2011, and 2016–2018. Results: Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016–2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Conclusions: Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/21758
http://hdl.handle.net/10256/21758
url http://hdl.handle.net/10256/21758
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/ijerph19084802
info:eu-repo/semantics/altIdentifier/issn/1661-7827
info:eu-repo/semantics/altIdentifier/eissn/1660-4601
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI (Multidisciplinary Digital Publishing Institute)
publisher.none.fl_str_mv MDPI (Multidisciplinary Digital Publishing Institute)
dc.source.none.fl_str_mv International Journal of Environmental Research and Public Health, 2022, vol. 19, núm. 8, p. 4802
Articles publicats (D-CM)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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