Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs

The gut microbiota is a key player in the host metabolism. Some bacteria are able to ferment non-digestible compounds and produce short-chain fatty acids that the host can later transform and accumulate in tissue. In this study, we aimed to better understand the relationships between the microorgani...

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Autores: Sebastià, Cristina, Folch, Josep M., Ballester, Maria, Estellé, Jordi, Passols, Magí, Muñoz, María, García-Casco, Juan M., Fernández, Ana I., Castelló, Anna, Sánchez, Armand, Crespo-Piazuelo, Daniel
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12327/2771
Acesso em linha:http://hdl.handle.net/20.500.12327/2771
https://doi.org/10.1128/msystems.01049-23
Access Level:acceso abierto
Palavra-chave:636
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repository_id_str
spelling Interrelation between gut microbiota, SCFA, and fatty acid composition in pigsSebastià, CristinaFolch, Josep M.Ballester, MariaEstellé, JordiPassols, MagíMuñoz, MaríaGarcía-Casco, Juan M.Fernández, Ana I.Castelló, AnnaSánchez, ArmandCrespo-Piazuelo, Daniel636The gut microbiota is a key player in the host metabolism. Some bacteria are able to ferment non-digestible compounds and produce short-chain fatty acids that the host can later transform and accumulate in tissue. In this study, we aimed to better understand the relationships between the microorganisms and the short-chain fatty acid composition of the rectal content, including the possible linkage with the fatty acid composition in backfat and muscle of the pig. We studied a Duroc × Iberian crossbred population, and we found significant correlations between different bacterial and archaeal genera and the fatty acid profile. The abundance of n-butyric acid in the rectal content was positively associated with Prevotella spp. and negatively associated with Akkermansia spp., while conversely, the abundance of acetic acid was negatively and positively associated with the levels of Prevotella spp. and Akkermansia spp., respectively. The most abundant genus, Rikenellaceae RC9 gut group, had a positive correlation with palmitic acid in muscle and negative correlations with stearic acid in backfat and oleic acid in muscle. These results suggest the possible role of Prevotella spp. and Akkermansia spp. as biomarkers for acetic and n-butyric acids, and the relationship of Rikenellaceae RC9 gut group with the lipid metabolism, building up the potential, although indirect, role of the microbiota in the modification of the backfat and muscle fatty acid composition of the host.This research received funding from projects AGL2017-82641-R funded by MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe" and PID2020-112677RB-C22 funded by MCIN/AEI/10.13039/501100011033. Research at CRAG was also supported by grants SEV-2015-0533 and CEX2019-000902-S, funded by MCIN/AEI/10.13039/501100011033, and the CERCA Programme, Generalitat de Catalunya. Cristina Sebastià was funded with a FI-AGAUR PhD grant from the Generalitat de Catalunya (2020FI_B_00225). Magí Passols was recipient of grant PRE2018-085350 funded by MCIN/AEI/10.13039/501100011033 and by "ESF Investing in your future."info:eu-repo/semantics/publishedVersionAmerican Society for MicrobiologyProducció AnimalGenètica i Millora Animal2023info:eu-repo/semantics/article19http://hdl.handle.net/20.500.12327/2771https://doi.org/10.1128/msystems.01049-23reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésmSystemsMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-82641-R/ES/GENOMICA FUNCIONAL, BIOLOGIA DE SISTEMAS Y MICROBIOMICA APLICADAS A LA IDENTIFICACION DE REGULADORES GENETICOS DEL CRECIMIENTO, ENGRASAMIENTO Y CALIDAD DE LA CARNE EN PORCINO/MICINN/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-112677RB-C22/ES/FISIOLOGIA MOLECULAR DEL METABOLISMO ENERGETICO EN PORCINO: BASES PARA LA SELECCION DE LA EFICIENCIA PRODUCTIVA Y CALIDAD DE CARNE/MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/SEV-2015-0533/ES/ /MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/CEX2019-000902-S/ES/ /FEDER/ / /EU/ /Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12327/27712026-05-29T05:05:01Z
dc.title.none.fl_str_mv Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
title Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
spellingShingle Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
Sebastià, Cristina
636
title_short Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
title_full Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
title_fullStr Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
title_full_unstemmed Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
title_sort Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
dc.creator.none.fl_str_mv Sebastià, Cristina
Folch, Josep M.
Ballester, Maria
Estellé, Jordi
Passols, Magí
Muñoz, María
García-Casco, Juan M.
Fernández, Ana I.
Castelló, Anna
Sánchez, Armand
Crespo-Piazuelo, Daniel
author Sebastià, Cristina
author_facet Sebastià, Cristina
Folch, Josep M.
Ballester, Maria
Estellé, Jordi
Passols, Magí
Muñoz, María
García-Casco, Juan M.
Fernández, Ana I.
Castelló, Anna
Sánchez, Armand
Crespo-Piazuelo, Daniel
author_role author
author2 Folch, Josep M.
Ballester, Maria
Estellé, Jordi
Passols, Magí
Muñoz, María
García-Casco, Juan M.
Fernández, Ana I.
Castelló, Anna
Sánchez, Armand
Crespo-Piazuelo, Daniel
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Producció Animal
Genètica i Millora Animal
dc.subject.none.fl_str_mv 636
topic 636
description The gut microbiota is a key player in the host metabolism. Some bacteria are able to ferment non-digestible compounds and produce short-chain fatty acids that the host can later transform and accumulate in tissue. In this study, we aimed to better understand the relationships between the microorganisms and the short-chain fatty acid composition of the rectal content, including the possible linkage with the fatty acid composition in backfat and muscle of the pig. We studied a Duroc × Iberian crossbred population, and we found significant correlations between different bacterial and archaeal genera and the fatty acid profile. The abundance of n-butyric acid in the rectal content was positively associated with Prevotella spp. and negatively associated with Akkermansia spp., while conversely, the abundance of acetic acid was negatively and positively associated with the levels of Prevotella spp. and Akkermansia spp., respectively. The most abundant genus, Rikenellaceae RC9 gut group, had a positive correlation with palmitic acid in muscle and negative correlations with stearic acid in backfat and oleic acid in muscle. These results suggest the possible role of Prevotella spp. and Akkermansia spp. as biomarkers for acetic and n-butyric acids, and the relationship of Rikenellaceae RC9 gut group with the lipid metabolism, building up the potential, although indirect, role of the microbiota in the modification of the backfat and muscle fatty acid composition of the host.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12327/2771
https://doi.org/10.1128/msystems.01049-23
url http://hdl.handle.net/20.500.12327/2771
https://doi.org/10.1128/msystems.01049-23
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv mSystems
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-82641-R/ES/GENOMICA FUNCIONAL, BIOLOGIA DE SISTEMAS Y MICROBIOMICA APLICADAS A LA IDENTIFICACION DE REGULADORES GENETICOS DEL CRECIMIENTO, ENGRASAMIENTO Y CALIDAD DE LA CARNE EN PORCINO/
MICINN/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-112677RB-C22/ES/FISIOLOGIA MOLECULAR DEL METABOLISMO ENERGETICO EN PORCINO: BASES PARA LA SELECCION DE LA EFICIENCIA PRODUCTIVA Y CALIDAD DE CARNE/
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/SEV-2015-0533/ES/ /
MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/CEX2019-000902-S/ES/ /
FEDER/ / /EU/ /
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 19
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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