Distribution of local ancestry and evidence of adaptation in admixed populations

Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time th...

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Autores: Secolin, Rodrigo, Mas-Sandoval, Alex, Arauna, Laura R., Torres, Fábio R., de Araujo, Tânia K., Santos, Marilza L., Rocha, Cristiane S., Carvalho, Benilton S., Cendes, Fernando, Lopes-Cendes, Iscia, Comas, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/207864
Acceso en línea:http://hdl.handle.net/10261/207864
Access Level:acceso abierto
Palabra clave:Evolutionary biology
Genetics
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spelling Distribution of local ancestry and evidence of adaptation in admixed populationsSecolin, RodrigoMas-Sandoval, AlexArauna, Laura R.Torres, Fábio R.de Araujo, Tânia K.Santos, Marilza L.Rocha, Cristiane S.Carvalho, Benilton S.Cendes, FernandoLopes-Cendes, IsciaComas, DavidEvolutionary biologyGeneticsAdmixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events.This study was supported by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil) grants BEPE-PD #2016/14423-9, and CEPID-BRAINN #2013/07559-3 IL-C and F.C. were also supported by grants from CNPq (Conselho Nacional de Pesquisa, Brazil). A.M.S., L.R.A. and D.C. were also supported by the Agència de Gestió d’Ajuts Universitaris i de la Recerca (Generalitat de Catalunya) grant 2014SGR866 and ‘Unidad de Excelencia María de Maeztu’ funded by MINECO (MDM-2014-0370).Springer NatureFundação de Amparo à Pesquisa do Estado de São PauloConselho Nacional das Fundaçôes Estaduais de Amparo à Pesquisa (Brasil)Generalitat de CatalunyaMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/207864reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2014-0370http://doi.org/10.1038/s41598-019-50362-2Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2078642026-05-22T06:33:51Z
dc.title.none.fl_str_mv Distribution of local ancestry and evidence of adaptation in admixed populations
title Distribution of local ancestry and evidence of adaptation in admixed populations
spellingShingle Distribution of local ancestry and evidence of adaptation in admixed populations
Secolin, Rodrigo
Evolutionary biology
Genetics
title_short Distribution of local ancestry and evidence of adaptation in admixed populations
title_full Distribution of local ancestry and evidence of adaptation in admixed populations
title_fullStr Distribution of local ancestry and evidence of adaptation in admixed populations
title_full_unstemmed Distribution of local ancestry and evidence of adaptation in admixed populations
title_sort Distribution of local ancestry and evidence of adaptation in admixed populations
dc.creator.none.fl_str_mv Secolin, Rodrigo
Mas-Sandoval, Alex
Arauna, Laura R.
Torres, Fábio R.
de Araujo, Tânia K.
Santos, Marilza L.
Rocha, Cristiane S.
Carvalho, Benilton S.
Cendes, Fernando
Lopes-Cendes, Iscia
Comas, David
author Secolin, Rodrigo
author_facet Secolin, Rodrigo
Mas-Sandoval, Alex
Arauna, Laura R.
Torres, Fábio R.
de Araujo, Tânia K.
Santos, Marilza L.
Rocha, Cristiane S.
Carvalho, Benilton S.
Cendes, Fernando
Lopes-Cendes, Iscia
Comas, David
author_role author
author2 Mas-Sandoval, Alex
Arauna, Laura R.
Torres, Fábio R.
de Araujo, Tânia K.
Santos, Marilza L.
Rocha, Cristiane S.
Carvalho, Benilton S.
Cendes, Fernando
Lopes-Cendes, Iscia
Comas, David
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional das Fundaçôes Estaduais de Amparo à Pesquisa (Brasil)
Generalitat de Catalunya
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Evolutionary biology
Genetics
topic Evolutionary biology
Genetics
description Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/207864
url http://hdl.handle.net/10261/207864
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2014-0370
http://doi.org/10.1038/s41598-019-50362-2
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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