The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals

Objectives: A decrease in blood cell counts, especially lymphocytes and eosinophils, has been described in patients with serious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but there is no knowledge of their potential role of the recovery in these patients' prognosis. This art...

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Authors: Mateos González M, Sierra Gonzalo E, Casado Lopez I, Arnalich Fernández F, Beato Pérez JL, Monge Monge D, Vargas Núñez JA, García Fenoll R, Suárez Fernández C, Freire Castro SJ, Mendez Bailon M, Perales Fraile I, Madrazo M, Pesqueira Fontan PM, Magallanes Gamboa JO, González García A, Crestelo Vieitez A, Fonseca Aizpuru EM, Aranguren Arostegui A, Coduras Erdozain A, Martinez Cilleros C, Loureiro Amigo J, Epelde F, Lumbreras Bermejo C, Antón Santos JM, For The Semi-Covid-Network
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8819
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/8819
Access Level:Open access
Keyword:2019-nCoV
SARS-CoV-2
coronavirus
COVID-19
eosinophil
prognosis
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spelling The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish HospitalsMateos González MSierra Gonzalo ECasado Lopez IArnalich Fernández FBeato Pérez JLMonge Monge DVargas Núñez JAGarcía Fenoll RSuárez Fernández CFreire Castro SJMendez Bailon MPerales Fraile IMadrazo MPesqueira Fontan PMMagallanes Gamboa JOGonzález García ACrestelo Vieitez AFonseca Aizpuru EMAranguren Arostegui ACoduras Erdozain AMartinez Cilleros CLoureiro Amigo JEpelde FLumbreras Bermejo CAntón Santos JMFor The Semi-Covid-Network2019-nCoVSARS-CoV-2coronavirusCOVID-19eosinophilprognosisObjectives: A decrease in blood cell counts, especially lymphocytes and eosinophils, has been described in patients with serious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but there is no knowledge of their potential role of the recovery in these patients' prognosis. This article aims to analyse the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Design: This work was a retrospective, multicentre cohort study of 9644 hospitalised patients with confirmed COVID-19 from the Spanish Society of Internal Medicine's SEMI-COVID-19 Registry. Setting: This study examined patients hospitalised in 147 hospitals throughout Spain. Participants: This work analysed 9644 patients (57.12% male) out of a cohort of 12,826 patients >= 18 years of age hospitalised with COVID-19 in Spain included in the SEMI-COVID-19 Registry as of 29 May 2020. Main outcome measures: The main outcome measure of this work is the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Univariate analysis was performed to determine possible predictors of death, and then multivariate analysis was carried out to control for potential confounders. Results: An increase in the eosinophil count on the seventh day of hospitalisation was associated with a better prognosis, including lower mortality rates (5.2% vs. 22.6% in non-recoverers, OR 0.234; 95% CI, 0.154 to 0.354) and lower complication rates, especially regarding the development of acute respiratory distress syndrome (8% vs. 20.1%, p = 0.000) and ICU admission (5.4% vs. 10.8%, p = 0.000). Lymphocyte recovery was found to have no effect on prognosis. Treatment with inhaled or systemic glucocorticoids was not found to be a confounding factor. Conclusion: Eosinophil recovery in patients with COVID-19 who required hospitalisation had an independent prognostic value for all-cause mortality and a milder course.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/8819Journal of Clinical MedicineISSN: 20770383reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p88192026-06-11T12:45:17Z
dc.title.none.fl_str_mv The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
title The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
spellingShingle The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
Mateos González M
2019-nCoV
SARS-CoV-2
coronavirus
COVID-19
eosinophil
prognosis
title_short The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
title_full The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
title_fullStr The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
title_full_unstemmed The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
title_sort The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
dc.creator.none.fl_str_mv Mateos González M
Sierra Gonzalo E
Casado Lopez I
Arnalich Fernández F
Beato Pérez JL
Monge Monge D
Vargas Núñez JA
García Fenoll R
Suárez Fernández C
Freire Castro SJ
Mendez Bailon M
Perales Fraile I
Madrazo M
Pesqueira Fontan PM
Magallanes Gamboa JO
González García A
Crestelo Vieitez A
Fonseca Aizpuru EM
Aranguren Arostegui A
Coduras Erdozain A
Martinez Cilleros C
Loureiro Amigo J
Epelde F
Lumbreras Bermejo C
Antón Santos JM
For The Semi-Covid-Network
author Mateos González M
author_facet Mateos González M
Sierra Gonzalo E
Casado Lopez I
Arnalich Fernández F
Beato Pérez JL
Monge Monge D
Vargas Núñez JA
García Fenoll R
Suárez Fernández C
Freire Castro SJ
Mendez Bailon M
Perales Fraile I
Madrazo M
Pesqueira Fontan PM
Magallanes Gamboa JO
González García A
Crestelo Vieitez A
Fonseca Aizpuru EM
Aranguren Arostegui A
Coduras Erdozain A
Martinez Cilleros C
Loureiro Amigo J
Epelde F
Lumbreras Bermejo C
Antón Santos JM
For The Semi-Covid-Network
author_role author
author2 Sierra Gonzalo E
Casado Lopez I
Arnalich Fernández F
Beato Pérez JL
Monge Monge D
Vargas Núñez JA
García Fenoll R
Suárez Fernández C
Freire Castro SJ
Mendez Bailon M
Perales Fraile I
Madrazo M
Pesqueira Fontan PM
Magallanes Gamboa JO
González García A
Crestelo Vieitez A
Fonseca Aizpuru EM
Aranguren Arostegui A
Coduras Erdozain A
Martinez Cilleros C
Loureiro Amigo J
Epelde F
Lumbreras Bermejo C
Antón Santos JM
For The Semi-Covid-Network
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 2019-nCoV
SARS-CoV-2
coronavirus
COVID-19
eosinophil
prognosis
topic 2019-nCoV
SARS-CoV-2
coronavirus
COVID-19
eosinophil
prognosis
description Objectives: A decrease in blood cell counts, especially lymphocytes and eosinophils, has been described in patients with serious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but there is no knowledge of their potential role of the recovery in these patients' prognosis. This article aims to analyse the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Design: This work was a retrospective, multicentre cohort study of 9644 hospitalised patients with confirmed COVID-19 from the Spanish Society of Internal Medicine's SEMI-COVID-19 Registry. Setting: This study examined patients hospitalised in 147 hospitals throughout Spain. Participants: This work analysed 9644 patients (57.12% male) out of a cohort of 12,826 patients >= 18 years of age hospitalised with COVID-19 in Spain included in the SEMI-COVID-19 Registry as of 29 May 2020. Main outcome measures: The main outcome measure of this work is the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Univariate analysis was performed to determine possible predictors of death, and then multivariate analysis was carried out to control for potential confounders. Results: An increase in the eosinophil count on the seventh day of hospitalisation was associated with a better prognosis, including lower mortality rates (5.2% vs. 22.6% in non-recoverers, OR 0.234; 95% CI, 0.154 to 0.354) and lower complication rates, especially regarding the development of acute respiratory distress syndrome (8% vs. 20.1%, p = 0.000) and ICU admission (5.4% vs. 10.8%, p = 0.000). Lymphocyte recovery was found to have no effect on prognosis. Treatment with inhaled or systemic glucocorticoids was not found to be a confounding factor. Conclusion: Eosinophil recovery in patients with COVID-19 who required hospitalisation had an independent prognostic value for all-cause mortality and a milder course.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/8819
url https://fisabio.portalinvestigacion.com/publicaciones/8819
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413249508704256
score 15,812429

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