Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study

Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on Metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases, which usually have a pathophysiolo...

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Detalles Bibliográficos
Autores: Montemayor, S. (Sofía)|||/items/91594836-00ee-4dcb-bb25-9cde424c178a, Mascaró, C.M. (Catalina M.)|||/items/9577d7ec-2536-4901-b68e-1b6db5edfd49, Ugarriza, L. (Lucía)|||/items/18cfdc5b-b110-46ce-8c09-c875326947fc, Casares, M. (Miguel)|||/items/8e73a453-b0c7-4c16-8ecd-b1eb5cdaa190, Llompart, I. (Isabel)|||/items/e603c669-2ecd-41b5-8695-37c3954038a7, Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb, Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e, Bouzas, C. (Cristina)|||/items/ee7406c3-ab99-4d0d-9526-305c39bdf84c
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/116751
Acceso en línea:https://hdl.handle.net/10171/116751
Access Level:acceso abierto
Palabra clave:Mediterranean diet
NAFLD
Intrahepatic fat contents
Metabolic syndrome
Non-alcoholic fat liver disease
Descripción
Sumario:Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on Metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases, which usually have a pathophysiological relationship with NAFLD. To assess the effect of adherence to a MedDiet on NAFLD in MetS patients after lifestyle intervention, this multicentre (Mallorca and Navarra, Spain) prospective randomized trial, with personalized nutritional intervention based on a customized MedDiet, coupled with physical activity promotion was performed to prevent, and reverse NAFLD among patients with MetS. The current analysis included 138 patients aged 40 to 60 years old, Body Mass Index (BMI) 27-40 kg/m2, diagnosed with NAFLD using MRI, and MetS according to the International Diabetes Federation (IDF). A validated food frequency questionnaire was used to assess dietary intake. Adherence to Mediterranean diet by means of a 17-item validated questionnaire, anthropometrics, physical activity, blood pressure, blood biochemical parameters, and intrahepatic fat contents (IFC) were measured. The independent variable used was changes in MedDiet adherence, categorized in tertiles after 6 months follow-up. Subjects with high adherence to the MedDiet showed higher decreases in BMI, body weight, WC, SBP, DBP, and IFC. An association between improvement in adherence to the MedDiet and amelioration of IFC after 6-month follow-up was observed. High adherence to the MedDiet is associated with better status of MetS features, and better values of IFC.

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