Clinical outcomes of a zika virus mother–child pair cohort in Spain
Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers d...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/694003 |
| Acceso en línea: | http://hdl.handle.net/10486/694003 https://dx.doi.org/10.3390/pathogens9050352 |
| Access Level: | acceso abierto |
| Palabra clave: | Adverse outcome Arboviruses Congenital infection Microcephaly Zika virus Medicina |
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Clinical outcomes of a zika virus mother–child pair cohort in SpainSoriano-Arandes, AntoniFrick, Marie AntoinetteLópez-Hortelano, Milagros GarcíaSulleiro, ElenaRodó, CarlotaSánchez-Seco, María PazCabrera-Lafuente, MartaSuy, AnnaCalle Fernández-Miranda, María de laSantos, MarAntolín Alvarado, María EugeniaViñuela, María Del CarmenEspiau, MaríaSalazar, AinaraGuarch-Ibáñez, BorjaVázquez, AnaNavarro-Morón, JuanRamos-Amador, José TomásMartin-Nalda, AndreaDueñas, EvaBlázquez-Gamero, DanielReques-Cosme, ResurrecciónOlabarrieta, IciarPrieto, LuisDe Ory, FernandoThorne, ClaireByrne, ThomasAdes, Anthony E.Ruiz-Burga, ElisaGiaquinto, CarloMellado Peña, María JoséGarcía-Alix, AlfredoCarreras, ElenaSoler-Palacín, PereAdverse outcomeArbovirusesCongenital infectionMicrocephalyZika virusMedicinaBackground: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.This work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 734857 (ZIKAction)MDPI, Basel, SMwitzerlandDepartamento de Obstetricia y GinecologíaDepartamento de PediatríaFacultad de MedicinaInstituto de Investigación Sanitaria del Hospital Universitario de La Paz (IdiPAZ)20202020-05-07research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/694003https://dx.doi.org/10.3390/pathogens9050352reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 734857open accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6940032026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Clinical outcomes of a zika virus mother–child pair cohort in Spain |
| title |
Clinical outcomes of a zika virus mother–child pair cohort in Spain |
| spellingShingle |
Clinical outcomes of a zika virus mother–child pair cohort in Spain Soriano-Arandes, Antoni Adverse outcome Arboviruses Congenital infection Microcephaly Zika virus Medicina |
| title_short |
Clinical outcomes of a zika virus mother–child pair cohort in Spain |
| title_full |
Clinical outcomes of a zika virus mother–child pair cohort in Spain |
| title_fullStr |
Clinical outcomes of a zika virus mother–child pair cohort in Spain |
| title_full_unstemmed |
Clinical outcomes of a zika virus mother–child pair cohort in Spain |
| title_sort |
Clinical outcomes of a zika virus mother–child pair cohort in Spain |
| dc.creator.none.fl_str_mv |
Soriano-Arandes, Antoni Frick, Marie Antoinette López-Hortelano, Milagros García Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna Calle Fernández-Miranda, María de la Santos, Mar Antolín Alvarado, María Eugenia Viñuela, María Del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere |
| author |
Soriano-Arandes, Antoni |
| author_facet |
Soriano-Arandes, Antoni Frick, Marie Antoinette López-Hortelano, Milagros García Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna Calle Fernández-Miranda, María de la Santos, Mar Antolín Alvarado, María Eugenia Viñuela, María Del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere |
| author_role |
author |
| author2 |
Frick, Marie Antoinette López-Hortelano, Milagros García Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna Calle Fernández-Miranda, María de la Santos, Mar Antolín Alvarado, María Eugenia Viñuela, María Del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Obstetricia y Ginecología Departamento de Pediatría Facultad de Medicina Instituto de Investigación Sanitaria del Hospital Universitario de La Paz (IdiPAZ) |
| dc.subject.none.fl_str_mv |
Adverse outcome Arboviruses Congenital infection Microcephaly Zika virus Medicina |
| topic |
Adverse outcome Arboviruses Congenital infection Microcephaly Zika virus Medicina |
| description |
Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-05-07 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/694003 https://dx.doi.org/10.3390/pathogens9050352 |
| url |
http://hdl.handle.net/10486/694003 https://dx.doi.org/10.3390/pathogens9050352 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 734857 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI, Basel, SMwitzerland |
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MDPI, Basel, SMwitzerland |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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15,301603 |