Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid

Background: Poor response to TB therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic parameters can be affected by comorbidities or the interaction of drugs with food. Objectives: This study aimed to determine the effect of food intake upon pharmacokinet...

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Autores: Requena-Méndez, Ana, Davies, Geraint, Waterhouse, David, Ardrey, Alison, Jave, Oswaldo, Llanet López-Romero, Sonia, Ward, Stephen A., Moore, David A. J.
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/128328
Acceso en línea:https://hdl.handle.net/2445/128328
Access Level:acceso abierto
Palabra clave:Tuberculosi
Farmacocinètica
Tuberculosis
Pharmacokinetics
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spelling Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazidRequena-Méndez, AnaDavies, GeraintWaterhouse, DavidArdrey, AlisonJave, OswaldoLlanet López-Romero, SoniaWard, Stephen A.Moore, David A. J.TuberculosiFarmacocinèticaTuberculosisPharmacokineticsBackground: Poor response to TB therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic parameters can be affected by comorbidities or the interaction of drugs with food. Objectives: This study aimed to determine the effect of food intake upon pharmacokinetics of rifampicin and isoniazid in a Peruvian population with TB. Methods: Rifampicin and isoniazid levels were analysed at 2, 4 and 6 h after drug intake in both fasting and non-fasting states using LC-MS methods. Results: Sixty patients participated in the study. The median rifampicin Cmax and AUC0–6 were higher during fasting than non-fasting: 7.02 versus 6.59 mg/L (P = 0.054) and 28.64 versus 24.31 mg·h/L (P = 0.002). There was a statistically significant delay overall of non-fasting Tmax compared with the fasting state Tmax (P = 0.005). In the multivariate analysis, besides the effect of fasting, Cmax for females was 20% higher than for males (P = 0.03). Concerning isoniazid, there were significant differences in the Cmax during non-fasting (median = 3.51 mg/L) compared with fasting (4.54 mg/L). The isoniazid dose received had an effect upon the isoniazid levels (1.26, P = 0.038). In the multivariate analysis, isoniazid exposure during fasting was found to be 14% higher than during non-fasting (CI = 1.02–1.28, P < 0.001). Neither radiological extent of the disease nor consumption of food with drug intake nor pharmacokinetics of rifampicin or isoniazid was associated with a poorer treatment outcome. Conclusions: Rifampicin in particular and isoniazid pharmacokinetics were significantly affected by the intake of the drug with food between and within individuals.Oxford University Press2019201920182019info:eu-repo/semantics/article9 p.application/pdfhttps://hdl.handle.net/2445/128328Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: http://dx.doi.org/ 10.1093/jac/dky444Journal of Antimicrobial Chemotherapy, 2019, vol. 74, num. 2, p. 416–424http://dx.doi.org/ 10.1093/jac/dky444(c) Oxford University Press, 2019info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1283282026-05-29T05:05:01Z
dc.title.none.fl_str_mv Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
title Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
spellingShingle Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
Requena-Méndez, Ana
Tuberculosi
Farmacocinètica
Tuberculosis
Pharmacokinetics
title_short Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
title_full Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
title_fullStr Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
title_full_unstemmed Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
title_sort Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid
dc.creator.none.fl_str_mv Requena-Méndez, Ana
Davies, Geraint
Waterhouse, David
Ardrey, Alison
Jave, Oswaldo
Llanet López-Romero, Sonia
Ward, Stephen A.
Moore, David A. J.
author Requena-Méndez, Ana
author_facet Requena-Méndez, Ana
Davies, Geraint
Waterhouse, David
Ardrey, Alison
Jave, Oswaldo
Llanet López-Romero, Sonia
Ward, Stephen A.
Moore, David A. J.
author_role author
author2 Davies, Geraint
Waterhouse, David
Ardrey, Alison
Jave, Oswaldo
Llanet López-Romero, Sonia
Ward, Stephen A.
Moore, David A. J.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosi
Farmacocinètica
Tuberculosis
Pharmacokinetics
topic Tuberculosi
Farmacocinètica
Tuberculosis
Pharmacokinetics
description Background: Poor response to TB therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic parameters can be affected by comorbidities or the interaction of drugs with food. Objectives: This study aimed to determine the effect of food intake upon pharmacokinetics of rifampicin and isoniazid in a Peruvian population with TB. Methods: Rifampicin and isoniazid levels were analysed at 2, 4 and 6 h after drug intake in both fasting and non-fasting states using LC-MS methods. Results: Sixty patients participated in the study. The median rifampicin Cmax and AUC0–6 were higher during fasting than non-fasting: 7.02 versus 6.59 mg/L (P = 0.054) and 28.64 versus 24.31 mg·h/L (P = 0.002). There was a statistically significant delay overall of non-fasting Tmax compared with the fasting state Tmax (P = 0.005). In the multivariate analysis, besides the effect of fasting, Cmax for females was 20% higher than for males (P = 0.03). Concerning isoniazid, there were significant differences in the Cmax during non-fasting (median = 3.51 mg/L) compared with fasting (4.54 mg/L). The isoniazid dose received had an effect upon the isoniazid levels (1.26, P = 0.038). In the multivariate analysis, isoniazid exposure during fasting was found to be 14% higher than during non-fasting (CI = 1.02–1.28, P < 0.001). Neither radiological extent of the disease nor consumption of food with drug intake nor pharmacokinetics of rifampicin or isoniazid was associated with a poorer treatment outcome. Conclusions: Rifampicin in particular and isoniazid pharmacokinetics were significantly affected by the intake of the drug with food between and within individuals.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/128328
url https://hdl.handle.net/2445/128328
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/ 10.1093/jac/dky444
Journal of Antimicrobial Chemotherapy, 2019, vol. 74, num. 2, p. 416–424
http://dx.doi.org/ 10.1093/jac/dky444
dc.rights.none.fl_str_mv (c) Oxford University Press, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Oxford University Press, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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