Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders

Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present...

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Autores: Flores López, María, García-Marchena, Nuria, Araos, Pedro, Requena-Ocaña, Nerea, Porras-Perales, Oscar, Torres-Galván, Sandra, Suárez, Juan, Pizarro Lozano, Ma. Nieves, Torre Fornell, Rafael de la, Rubio, Gabriel, Ruiz-Ruiz, Juan Jesús, Rodríguez de Fonseca, Fernando, Serrano, Antonia, Pavón, Francisco Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53515
Acceso en línea:http://hdl.handle.net/10230/53515
http://dx.doi.org/10.3390/brainsci12050588
Access Level:acceso abierto
Palabra clave:Alcohol
Biomarker
Cocaine
Lysophosphatidic acid
Sex
Substance use disorder
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spelling Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disordersFlores López, MaríaGarcía-Marchena, NuriaAraos, PedroRequena-Ocaña, NereaPorras-Perales, OscarTorres-Galván, SandraSuárez, JuanPizarro Lozano, Ma. NievesTorre Fornell, Rafael de laRubio, GabrielRuiz-Ruiz, Juan JesúsRodríguez de Fonseca, FernandoSerrano, AntoniaPavón, Francisco JavierAlcoholBiomarkerCocaineLysophosphatidic acidSexSubstance use disorderPreclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.MDPI202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53515http://dx.doi.org/10.3390/brainsci12050588reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBrain Sci. 2022 Apr 30;12(5):588© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/535152026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
title Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
spellingShingle Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
Flores López, María
Alcohol
Biomarker
Cocaine
Lysophosphatidic acid
Sex
Substance use disorder
title_short Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
title_full Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
title_fullStr Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
title_full_unstemmed Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
title_sort Sex differences in plasma Lysophosphatidic Acid Species in patients with alcohol and cocaine use disorders
dc.creator.none.fl_str_mv Flores López, María
García-Marchena, Nuria
Araos, Pedro
Requena-Ocaña, Nerea
Porras-Perales, Oscar
Torres-Galván, Sandra
Suárez, Juan
Pizarro Lozano, Ma. Nieves
Torre Fornell, Rafael de la
Rubio, Gabriel
Ruiz-Ruiz, Juan Jesús
Rodríguez de Fonseca, Fernando
Serrano, Antonia
Pavón, Francisco Javier
author Flores López, María
author_facet Flores López, María
García-Marchena, Nuria
Araos, Pedro
Requena-Ocaña, Nerea
Porras-Perales, Oscar
Torres-Galván, Sandra
Suárez, Juan
Pizarro Lozano, Ma. Nieves
Torre Fornell, Rafael de la
Rubio, Gabriel
Ruiz-Ruiz, Juan Jesús
Rodríguez de Fonseca, Fernando
Serrano, Antonia
Pavón, Francisco Javier
author_role author
author2 García-Marchena, Nuria
Araos, Pedro
Requena-Ocaña, Nerea
Porras-Perales, Oscar
Torres-Galván, Sandra
Suárez, Juan
Pizarro Lozano, Ma. Nieves
Torre Fornell, Rafael de la
Rubio, Gabriel
Ruiz-Ruiz, Juan Jesús
Rodríguez de Fonseca, Fernando
Serrano, Antonia
Pavón, Francisco Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alcohol
Biomarker
Cocaine
Lysophosphatidic acid
Sex
Substance use disorder
topic Alcohol
Biomarker
Cocaine
Lysophosphatidic acid
Sex
Substance use disorder
description Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53515
http://dx.doi.org/10.3390/brainsci12050588
url http://hdl.handle.net/10230/53515
http://dx.doi.org/10.3390/brainsci12050588
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Brain Sci. 2022 Apr 30;12(5):588
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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