Rationale and Design of the Efficacy of a Standardized Diuretic Protocol in Acute Heart Failure Study

Aims: Although acute heart failure (AHF) with volume overload is treated with loop diuretics, their dosing and type of administration are mainly based upon expert opinion. A recent position paper from the Heart Failure Association (HFA) proposed a step-wise pharmacologic diuretic strategy to increas...

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Autores: Dauw, Jeroen|||0000-0003-4605-3450, Lelonek, Malgorzata|||0000-0003-0756-5541, Zegrí-Reiriz, Isabel|||0000-0001-9742-8537, Paredes-Paucar, Cynthia P.|||0000-0003-0734-6437, Zara, Cornelia Ancuta, George, Varghese|||0000-0002-4248-8513, Cobo-Marcos, M.|||0000-0002-9026-061X, Knappe, Dorit, Shchekochikhin, Dimitry|||0000-0002-8209-2791, Lekhakul, Annop, Klincheva, Milka, Frea, Simone|||0000-0002-2977-3299, Miró, Oscar|||0000-0002-7924-9751, Barker, Diane, Borbély, Attila, Nasr, Samer|||0000-0002-3695-6042, Doghmi, Nawal|||0000-0001-6677-5106, De la Espriella, Rafael|||0000-0002-8720-3999, Singh, Jagdeep S.|||0000-0002-7358-9712, Bovolo, Virginia, Fialho, Inês|||0000-0002-0331-3358, Ross, Noel T.|||0000-0001-5561-5940, van den Heuvel, Mieke, Benkouar, Riad, Findeisen, Hajo|||0000-0003-0180-5452, Alhaddad, Imad A., Al Balbissi, Kais, Barge-Caballero, Gonzalo|||0000-0001-5662-5323, Ghazi, Azmee M., Bruckers, Liesbeth|||0000-0002-6978-3002, Martens, P.|||0000-0002-6036-2113, Mullens, Wilfried|||0000-0001-9995-8590
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:270217
Acceso en línea:https://ddd.uab.cat/record/270217
https://dx.doi.org/urn:doi:10.1002/ehf2.13666
Access Level:acceso abierto
Palabra clave:Diuretics
Furosemide
Heart Failure
Humans
Infusions, Intravenous
Sodium Potassium Chloride Symporter Inhibitors
Acute heart failure
Urinary sodium
Decongestion
Protocol
Descripción
Sumario:Aims: Although acute heart failure (AHF) with volume overload is treated with loop diuretics, their dosing and type of administration are mainly based upon expert opinion. A recent position paper from the Heart Failure Association (HFA) proposed a step-wise pharmacologic diuretic strategy to increase the diuretic response and to achieve rapid decongestion. However, no study has evaluated this protocol prospectively. Methods and results: The Efficacy of a Standardized Diuretic Protocol in Acute Heart Failure (ENACT-HF) study is an international, multicentre, non-randomized, open-label, pragmatic study in AHF patients on chronic loop diuretic therapy, admitted to the hospital for intravenous loop diuretic therapy, aiming to enrol 500 patients. Inclusion criteria are as follows: at least one sign of volume overload (oedema, ascites, or pleural effusion), use ≥ 40 mg of furosemide or equivalent for.

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