The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning

Acute myocardial infarction; Ischemic preconditioning; Pig

Detalles Bibliográficos
Autores: Kleinbongard, Petra, Galán-Arriola, Carlos, Badimon, Lina, Crisostomo, Verónica, Giricz, Zoltán, Gyöngyösi, Mariann, Rodriguez-Sinovas, Antonio, Ruiz Meana, Marisol
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/12458
Acceso en línea:https://hdl.handle.net/11351/12458
http://hdl.handle.net/11351/12458
Access Level:acceso abierto
Palabra clave:Porcs
Infart de miocardi - Prevenció
Infart de miocardi - Tractament
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Artiodactyla::Swine
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Ischemic Preconditioning::Ischemic Preconditioning, Myocardial
DISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial Infarction
Other subheadings::Other subheadings::Other subheadings::/prevention & control
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::artiodáctilos::porcinos
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::precondicionamiento isquémico::precondicionamiento isquémico miocárdico
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::infarto de miocardio
Otros calificadores::Otros calificadores::Otros calificadores::/prevención & control
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oai_identifier_str oai:recercat.cat:11351/12458
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
title The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
spellingShingle The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
Kleinbongard, Petra
Porcs
Infart de miocardi - Prevenció
Infart de miocardi - Tractament
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Artiodactyla::Swine
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Ischemic Preconditioning::Ischemic Preconditioning, Myocardial
DISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial Infarction
Other subheadings::Other subheadings::Other subheadings::/prevention & control
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::artiodáctilos::porcinos
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::precondicionamiento isquémico::precondicionamiento isquémico miocárdico
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::infarto de miocardio
Otros calificadores::Otros calificadores::Otros calificadores::/prevención & control
title_short The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
title_full The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
title_fullStr The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
title_full_unstemmed The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
title_sort The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
dc.creator.none.fl_str_mv Kleinbongard, Petra
Galán-Arriola, Carlos
Badimon, Lina
Crisostomo, Verónica
Giricz, Zoltán
Gyöngyösi, Mariann
Rodriguez-Sinovas, Antonio
Ruiz Meana, Marisol
author Kleinbongard, Petra
author_facet Kleinbongard, Petra
Galán-Arriola, Carlos
Badimon, Lina
Crisostomo, Verónica
Giricz, Zoltán
Gyöngyösi, Mariann
Rodriguez-Sinovas, Antonio
Ruiz Meana, Marisol
author_role author
author2 Galán-Arriola, Carlos
Badimon, Lina
Crisostomo, Verónica
Giricz, Zoltán
Gyöngyösi, Mariann
Rodriguez-Sinovas, Antonio
Ruiz Meana, Marisol
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Kleinbongard P] Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, University of Duisburg-Essen, Essen, Germany. [Galán Arriola C] Centro Nacional de Investigaciones Cardiovasculares Carlos III, CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Badimon L] Research Institute Hospital de La Santa Creu I Sant Pau-IIB Sant Pau, and CIBER Enfermedades Cardiovasculares, Barcelona, Spain. [Crisostomo V] Cardiovascular Area, Jesús Usón Minimally Invasive Surgery Centre (CCMIJU), Cáceres, Spain. CIBER de Enfermedades Cardiovasculares (CIBERCV), RICORS-TERAV Network, ISCIII, Madrid, Spain. [Giricz Z] Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary. Pharmahungary Group, Szeged, Hungary. [Gyöngyösi M] Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria. [Rodríguez Sinovas A, Ruiz Meana M] Grup de Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Porcs
Infart de miocardi - Prevenció
Infart de miocardi - Tractament
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Artiodactyla::Swine
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Ischemic Preconditioning::Ischemic Preconditioning, Myocardial
DISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial Infarction
Other subheadings::Other subheadings::Other subheadings::/prevention & control
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::artiodáctilos::porcinos
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::precondicionamiento isquémico::precondicionamiento isquémico miocárdico
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::infarto de miocardio
Otros calificadores::Otros calificadores::Otros calificadores::/prevención & control
topic Porcs
Infart de miocardi - Prevenció
Infart de miocardi - Tractament
ORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Artiodactyla::Swine
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Ischemic Preconditioning::Ischemic Preconditioning, Myocardial
DISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial Infarction
Other subheadings::Other subheadings::Other subheadings::/prevention & control
ORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::artiodáctilos::porcinos
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::precondicionamiento isquémico::precondicionamiento isquémico miocárdico
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::infarto de miocardio
Otros calificadores::Otros calificadores::Otros calificadores::/prevención & control
description Acute myocardial infarction; Ischemic preconditioning; Pig
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/12458
http://hdl.handle.net/11351/12458
url https://hdl.handle.net/11351/12458
http://hdl.handle.net/11351/12458
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Basic Research in Cardiology;119
https://doi.org/10.1007/s00395-024-01083-9
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioningKleinbongard, PetraGalán-Arriola, CarlosBadimon, LinaCrisostomo, VerónicaGiricz, ZoltánGyöngyösi, MariannRodriguez-Sinovas, AntonioRuiz Meana, MarisolPorcsInfart de miocardi - PrevencióInfart de miocardi - TractamentORGANISMS::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Eutheria::Artiodactyla::SwineANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Ischemic Preconditioning::Ischemic Preconditioning, MyocardialDISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial InfarctionOther subheadings::Other subheadings::Other subheadings::/prevention & controlORGANISMOS::Eukaryota::animales::Chordata::vertebrados::mamíferos::Eutheria::artiodáctilos::porcinosTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::precondicionamiento isquémico::precondicionamiento isquémico miocárdicoENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::infarto de miocardioOtros calificadores::Otros calificadores::Otros calificadores::/prevención & controlAcute myocardial infarction; Ischemic preconditioning; PigInfarto agudo de miocardio; Preacondicionamiento isquémico; CerdoInfart agut de miocardi; Precondicionament isquèmic; PorcNumerous cardioprotective interventions have been reported to reduce myocardial infarct size (IS) in pre-clinical studies. However, their translation for the benefit of patients with acute myocardial infarction (AMI) has been largely disappointing. One reason for the lack of translation is the lack of rigor and reproducibility in pre-clinical studies. To address this, we have established the European IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) pig AMI network with centralized randomization and blinded core laboratory IS analysis and validated the network with ischemic preconditioning (IPC) as a positive control. Ten sites in the COST Innovators Grant (IG16225) network participated in the IMPACT network. Three sites were excluded from the final analysis through quality control of infarct images and use of pre-defined exclusion criteria. Using a centrally generated randomization list, pigs were allocated to myocardial ischemia/reperfusion (I/R, N = 5/site) or IPC + I/R (N = 5/site). The primary endpoint was IS [% area-at-risk (AAR)], as quantified by triphenyl-tetrazolium-chloride (TTC) staining in a centralized, blinded core laboratory (5 sites), or IS [% left-ventricular mass (LV)], as quantified by a centralized, blinded cardiac magnetic resonance (CMR) core laboratory (2 sites). In pooled analyses, IPC significantly reduced IS when compared to I/R (57 ± 14 versus 32 ± 19 [%AAR] N = 25 pigs/group; p < 0.001; 25 ± 13 versus 14 ± 8 [%LV]; N = 10 pigs/group; p = 0.021). In site-specific analyses, in 4 of the 5 sites, IS was significantly reduced by IPC when compared to I/R when quantified by TTC and in 1 of 2 sites when quantified by CMR. A pig AMI multicenter European network with centralized randomization and core blinded IS analysis was established and validated with the aim to improve the reproducibility of cardioprotective interventions in pre-clinical studies and the translation of cardioprotection for patient benefit.Open Access funding enabled and organized by Projekt DEAL. DJH is supported by the Duke-NUS Signature Research Program funded by the Ministry of Health, Singapore Ministry of Health’s National Medical Research Council under its Singapore Translational Research Investigator Award (MOH-STaR21jun-0003), Centre Grant scheme (NMRC CG21APR1006), and Collaborative Centre Grant scheme (NMRC/CG21APRC006). The Ministry for Innovation and Technology in Hungary provided funding to this study under the 2020–1.1.5-GYORSÍTÓSÁV call program (2020-1.1.5-GYORSÍTÓSÁV-2021-00011), also supported by project no. RRF-2.3.1-21-2022-00003 “National Heart Laboratory, Hungary” and by the Hungarian National Scientific Research Fund (OTKA-138223). CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN), and the Pro CNIC Foundation), and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/https://doi.org/10.13039/501100011033). GH and PK were supported by the German Research Foundation (CRC 1116 B8, RTG 2989) and EU COST Action METAHEART (CA 22169). VC is supported by the Instituto de Salud Carlos III (ISCIII, grant PI20/0247). AK and BKP are supported by the Ludwig Boltzmann Gesellschaft (CARREM). This article is based on work supported by the COST Actions EU-CARDIOPROTECTION CA16225 and IG16225.SpringerInstitut Català de la Salut[Kleinbongard P] Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, University of Duisburg-Essen, Essen, Germany. [Galán Arriola C] Centro Nacional de Investigaciones Cardiovasculares Carlos III, CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Badimon L] Research Institute Hospital de La Santa Creu I Sant Pau-IIB Sant Pau, and CIBER Enfermedades Cardiovasculares, Barcelona, Spain. [Crisostomo V] Cardiovascular Area, Jesús Usón Minimally Invasive Surgery Centre (CCMIJU), Cáceres, Spain. CIBER de Enfermedades Cardiovasculares (CIBERCV), RICORS-TERAV Network, ISCIII, Madrid, Spain. [Giricz Z] Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary. Pharmahungary Group, Szeged, Hungary. [Gyöngyösi M] Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria. [Rodríguez Sinovas A, Ruiz Meana M] Grup de Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, SpainVall d'Hebron Barcelona Hospital Campus202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/12458http://hdl.handle.net/11351/12458Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBasic Research in Cardiology;119https://doi.org/10.1007/s00395-024-01083-9Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/124582026-05-29T05:05:01Z
score 15.81155

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