Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants
Background: There is increasing interest in the potential effects of polybrominated diphenyl ethers (PBDEs) on children’s neuropsychological development, but only a few small studies have evaluated such effects. Objectives: Our goal was to examine the association between PBDE concentrations in colos...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/23370 |
| Acceso en línea: | http://hdl.handle.net/10230/23370 http://dx.doi.org/10.1289/ehp.1205266 |
| Access Level: | acceso abierto |
| Palabra clave: | Malalties immunològiques en els infants Infants -- Creixement Children Environmental Neurodevelopment Persistent organic pollutants (POPs) Polybrominated diphenyl ethers (PBDEs) |
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Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infantsGascon Merlos, Mireia, 1984-Fort, MartaMartínez, DavidCarsin, Anne-ElieForns i Guzman, Joan, 1981-Grimalt Obrador, JoanSanta Marina, LoretoLertxundi, NereaSunyer Deu, JordiVrijheid, MartineMalalties immunològiques en els infantsInfants -- CreixementChildrenEnvironmentalNeurodevelopmentPersistent organic pollutants (POPs)Polybrominated diphenyl ethers (PBDEs)Background: There is increasing interest in the potential effects of polybrominated diphenyl ethers (PBDEs) on children’s neuropsychological development, but only a few small studies have evaluated such effects. Objectives: Our goal was to examine the association between PBDE concentrations in colostrum and infant neuropsychological development and to assess the influence of other persistent organic pollutants (POPs) on such association. Methods: We measured concentrations of PBDEs and other POPs in colostrum samples of 290 women recruited in a Spanish birth cohort. We tested children for mental and psychomotor development with the Bayley Scales of Infant Development at 12–18 months of age. We analyzed the sum of the seven most common PBDE congeners (BDEs 47, 99, 100, 153, 154, 183, 209) and each congener separately. Results: Increasing Σ7PBDEs concentrations showed an association of borderline statistical significance with decreasing mental development scores (β per log ng/g lipid = –2.25; 95% CI: –4.75, 0.26). BDE-209, the congener present in highest concentrations, appeared to be the main congener responsible for this association (β = –2.40, 95% CI: –4.79, –0.01). There was little evidence for an association with psychomotor development. After adjustment for other POPs, the BDE-209 association with mental development score became slightly weaker (β = –2.10, 95% CI: –4.66, 0.46). Conclusions: Our findings suggest an association between increasing PBDE concentrations in colostrum and a worse infant mental development, particularly for BDE-209, but require confirmation in larger studies. The association, if causal, may be due to unmeasured BDE-209 metabolites, including OH-PBDEs (hydroxylated PBDEs), which are more toxic, more stable, and more likely to cross the placenta and to easily reach the brain than BDE-209.This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-PI06/0867, and FIS-PS09/00090), Spanish Ministry of Health (FIS-PI041436 and FIS- PI081151), Generalitat de Catalunya-CIRIT (1999SGR 00241), Department of Health of the Basque Government (2005111093 and 2009111069), the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001), and Fundación Roger TornéNational Institute of Environmental Health Sciences (NIEHS)201520152012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23370http://dx.doi.org/10.1289/ehp.1205266reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnvironmental Health Perspectives. 2012;120(12):1760-5Reproduced with permission from Environmental Health Perspectivesinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/233702026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants |
| title |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants |
| spellingShingle |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants Gascon Merlos, Mireia, 1984- Malalties immunològiques en els infants Infants -- Creixement Children Environmental Neurodevelopment Persistent organic pollutants (POPs) Polybrominated diphenyl ethers (PBDEs) |
| title_short |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants |
| title_full |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants |
| title_fullStr |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants |
| title_full_unstemmed |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants |
| title_sort |
Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants |
| dc.creator.none.fl_str_mv |
Gascon Merlos, Mireia, 1984- Fort, Marta Martínez, David Carsin, Anne-Elie Forns i Guzman, Joan, 1981- Grimalt Obrador, Joan Santa Marina, Loreto Lertxundi, Nerea Sunyer Deu, Jordi Vrijheid, Martine |
| author |
Gascon Merlos, Mireia, 1984- |
| author_facet |
Gascon Merlos, Mireia, 1984- Fort, Marta Martínez, David Carsin, Anne-Elie Forns i Guzman, Joan, 1981- Grimalt Obrador, Joan Santa Marina, Loreto Lertxundi, Nerea Sunyer Deu, Jordi Vrijheid, Martine |
| author_role |
author |
| author2 |
Fort, Marta Martínez, David Carsin, Anne-Elie Forns i Guzman, Joan, 1981- Grimalt Obrador, Joan Santa Marina, Loreto Lertxundi, Nerea Sunyer Deu, Jordi Vrijheid, Martine |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Malalties immunològiques en els infants Infants -- Creixement Children Environmental Neurodevelopment Persistent organic pollutants (POPs) Polybrominated diphenyl ethers (PBDEs) |
| topic |
Malalties immunològiques en els infants Infants -- Creixement Children Environmental Neurodevelopment Persistent organic pollutants (POPs) Polybrominated diphenyl ethers (PBDEs) |
| description |
Background: There is increasing interest in the potential effects of polybrominated diphenyl ethers (PBDEs) on children’s neuropsychological development, but only a few small studies have evaluated such effects. Objectives: Our goal was to examine the association between PBDE concentrations in colostrum and infant neuropsychological development and to assess the influence of other persistent organic pollutants (POPs) on such association. Methods: We measured concentrations of PBDEs and other POPs in colostrum samples of 290 women recruited in a Spanish birth cohort. We tested children for mental and psychomotor development with the Bayley Scales of Infant Development at 12–18 months of age. We analyzed the sum of the seven most common PBDE congeners (BDEs 47, 99, 100, 153, 154, 183, 209) and each congener separately. Results: Increasing Σ7PBDEs concentrations showed an association of borderline statistical significance with decreasing mental development scores (β per log ng/g lipid = –2.25; 95% CI: –4.75, 0.26). BDE-209, the congener present in highest concentrations, appeared to be the main congener responsible for this association (β = –2.40, 95% CI: –4.79, –0.01). There was little evidence for an association with psychomotor development. After adjustment for other POPs, the BDE-209 association with mental development score became slightly weaker (β = –2.10, 95% CI: –4.66, 0.46). Conclusions: Our findings suggest an association between increasing PBDE concentrations in colostrum and a worse infant mental development, particularly for BDE-209, but require confirmation in larger studies. The association, if causal, may be due to unmeasured BDE-209 metabolites, including OH-PBDEs (hydroxylated PBDEs), which are more toxic, more stable, and more likely to cross the placenta and to easily reach the brain than BDE-209. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2015 2015 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/23370 http://dx.doi.org/10.1289/ehp.1205266 |
| url |
http://hdl.handle.net/10230/23370 http://dx.doi.org/10.1289/ehp.1205266 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Environmental Health Perspectives. 2012;120(12):1760-5 |
| dc.rights.none.fl_str_mv |
Reproduced with permission from Environmental Health Perspectives info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Reproduced with permission from Environmental Health Perspectives |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
National Institute of Environmental Health Sciences (NIEHS) |
| publisher.none.fl_str_mv |
National Institute of Environmental Health Sciences (NIEHS) |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15.81155 |