Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents

Background: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. Methods: This cross-sectional study in...

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Autores: González-Jiménez, Emilio, Schmidt-RioValle, Jacqueline, Montero Alonso, Miguel Ángel, Padez, Cristina, García García, Carmen J., Perona, Javier S.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/147661
Acesso em linha:http://hdl.handle.net/10261/147661
Access Level:acceso abierto
Palavra-chave:Insulin resistance
Adolescence
HOMA-IR
Metabolic syndrome
Risk factors
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spelling Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in AdolescentsGonzález-Jiménez, EmilioSchmidt-RioValle, JacquelineMontero Alonso, Miguel ÁngelPadez, CristinaGarcía García, Carmen J.Perona, Javier S.Insulin resistanceAdolescenceHOMA-IRMetabolic syndromeRisk factorsBackground: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. Methods: This cross-sectional study included 976 adolescents from southeast Spain. Anthropometric and biochemical measurements were performed, and insulin resistance was assessed using the homeostasis model assessment–insulin resistance (HOMA-IR). Results: Subjects with abnormal HOMA-IR values had significantly higher body mass index (BMI), body fat content, waist circumference, and systolic blood pressure (BP) than those with normal values. Furthermore, levels of glucose, insulin, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, homocysteine, nonesterified fatty acids, and ceruloplasmin were higher in subjects with abnormal HOMA-IR values. Multivariate logistic regression analysis showed the highest odds ratio (OR) for BMI and that combinations of BMI with body fat content or systolic BP can increase the risk of insulin resistance 7-fold. Discussion: Anthropometric indicators have different levels of influence on the risk of insulin resistance in adolescents, and a combination of two of these indicators is enough to increase the risk 7-fold. Since the highest OR was observed for BMI, the greatest effort should be directed to reducing this parameter in adolescents. An adequate understanding by nursing personnel of factors associated with insulin resistance is a key factor in the prevention of this pathophysiological condition and its complications in adolescents.This work was supported by funds from the Spanish Ministry of Economy and Competitiveness (AGL2011-23810).Peer ReviewedSage PublicationsMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720162017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/147661reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1476612026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
title Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
spellingShingle Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
González-Jiménez, Emilio
Insulin resistance
Adolescence
HOMA-IR
Metabolic syndrome
Risk factors
title_short Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
title_full Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
title_fullStr Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
title_full_unstemmed Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
title_sort Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
dc.creator.none.fl_str_mv González-Jiménez, Emilio
Schmidt-RioValle, Jacqueline
Montero Alonso, Miguel Ángel
Padez, Cristina
García García, Carmen J.
Perona, Javier S.
author González-Jiménez, Emilio
author_facet González-Jiménez, Emilio
Schmidt-RioValle, Jacqueline
Montero Alonso, Miguel Ángel
Padez, Cristina
García García, Carmen J.
Perona, Javier S.
author_role author
author2 Schmidt-RioValle, Jacqueline
Montero Alonso, Miguel Ángel
Padez, Cristina
García García, Carmen J.
Perona, Javier S.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Insulin resistance
Adolescence
HOMA-IR
Metabolic syndrome
Risk factors
topic Insulin resistance
Adolescence
HOMA-IR
Metabolic syndrome
Risk factors
description Background: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. Methods: This cross-sectional study included 976 adolescents from southeast Spain. Anthropometric and biochemical measurements were performed, and insulin resistance was assessed using the homeostasis model assessment–insulin resistance (HOMA-IR). Results: Subjects with abnormal HOMA-IR values had significantly higher body mass index (BMI), body fat content, waist circumference, and systolic blood pressure (BP) than those with normal values. Furthermore, levels of glucose, insulin, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, homocysteine, nonesterified fatty acids, and ceruloplasmin were higher in subjects with abnormal HOMA-IR values. Multivariate logistic regression analysis showed the highest odds ratio (OR) for BMI and that combinations of BMI with body fat content or systolic BP can increase the risk of insulin resistance 7-fold. Discussion: Anthropometric indicators have different levels of influence on the risk of insulin resistance in adolescents, and a combination of two of these indicators is enough to increase the risk 7-fold. Since the highest OR was observed for BMI, the greatest effort should be directed to reducing this parameter in adolescents. An adequate understanding by nursing personnel of factors associated with insulin resistance is a key factor in the prevention of this pathophysiological condition and its complications in adolescents.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/147661
url http://hdl.handle.net/10261/147661
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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