Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients

Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinsons disease (PD) patients as compared to controls, which correlat...

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Detalhes bibliográficos
Autores: Fernández, Belén, Ferrer, Isidro (Ferrer Abizanda), Gil, Fernando, Hilfiker, Sabine
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/125261
Acesso em linha:https://hdl.handle.net/2445/125261
Access Level:Acceso aberto
Palavra-chave:Cervell
Ferro
Demència amb cossos de Lewy
Malaltia de Parkinson
Brain
Iron
Lewy body dementia
Parkinson's disease
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spelling Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patientsFernández, BelénFerrer, Isidro (Ferrer Abizanda)Gil, FernandoHilfiker, SabineCervellFerroDemència amb cossos de LewyMalaltia de ParkinsonBrainIronLewy body dementiaParkinson's diseaseIron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinsons disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features. Moreover, region-specific differences in iron load reflecting those in the human brain were detected in rodent brains as well. Whilst altered iron load was not observed in other regions also affected in PD patients, we report a significant increase in iron load in the SN of Lewy body disease patients as compared to Alzheimers disease (AD) patients or controls, which correlates with neurodegeneration in this brain area.Elsevier2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/125261Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.toxrep.2017.03.005Toxicology Reports, 2017, vol. 4, p. 188-193https://doi.org/10.1016/j.toxrep.2017.03.005cc by-nc-nd (c) Fernández et al., 2017http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1252612026-05-27T06:46:51Z
dc.title.none.fl_str_mv Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
title Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
spellingShingle Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
Fernández, Belén
Cervell
Ferro
Demència amb cossos de Lewy
Malaltia de Parkinson
Brain
Iron
Lewy body dementia
Parkinson's disease
title_short Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
title_full Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
title_fullStr Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
title_full_unstemmed Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
title_sort Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
dc.creator.none.fl_str_mv Fernández, Belén
Ferrer, Isidro (Ferrer Abizanda)
Gil, Fernando
Hilfiker, Sabine
author Fernández, Belén
author_facet Fernández, Belén
Ferrer, Isidro (Ferrer Abizanda)
Gil, Fernando
Hilfiker, Sabine
author_role author
author2 Ferrer, Isidro (Ferrer Abizanda)
Gil, Fernando
Hilfiker, Sabine
author2_role author
author
author
dc.subject.none.fl_str_mv Cervell
Ferro
Demència amb cossos de Lewy
Malaltia de Parkinson
Brain
Iron
Lewy body dementia
Parkinson's disease
topic Cervell
Ferro
Demència amb cossos de Lewy
Malaltia de Parkinson
Brain
Iron
Lewy body dementia
Parkinson's disease
description Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinsons disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features. Moreover, region-specific differences in iron load reflecting those in the human brain were detected in rodent brains as well. Whilst altered iron load was not observed in other regions also affected in PD patients, we report a significant increase in iron load in the SN of Lewy body disease patients as compared to Alzheimers disease (AD) patients or controls, which correlates with neurodegeneration in this brain area.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125261
url https://hdl.handle.net/2445/125261
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.toxrep.2017.03.005
Toxicology Reports, 2017, vol. 4, p. 188-193
https://doi.org/10.1016/j.toxrep.2017.03.005
dc.rights.none.fl_str_mv cc by-nc-nd (c) Fernández et al., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Fernández et al., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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