The biogenic amines putrescine and cadaverine show in vitro cytotoxicity at concentrations that can be found in foods

Putrescine and cadaverine are among the most common biogenic amines (BA) in foods, but it is advisable that their accumulation be avoided. Present knowledge about their toxicity is, however, limited; further research is needed if qualitative and quantitative risk assessments for foods are to be cond...

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Detalles Bibliográficos
Autores: Río Lagar, Beatriz del, Redruello, Begoña, Linares, Daniel M., Ladero Losada, Víctor Manuel, Ruas-Madiedo, Patricia, Fernández García, María, Martín, M. Cruz, Álvarez González, Miguel Ángel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/186190
Acceso en línea:http://hdl.handle.net/10261/186190
Access Level:acceso abierto
Descripción
Sumario:Putrescine and cadaverine are among the most common biogenic amines (BA) in foods, but it is advisable that their accumulation be avoided. Present knowledge about their toxicity is, however, limited; further research is needed if qualitative and quantitative risk assessments for foods are to be conducted. The present work describes a real-time analysis of the cytotoxicity of putrescine and cadaverine on intestinal cell cultures. Both BA were cytotoxic at concentrations found in BA-rich foods, although the cytotoxicity threshold for cadaverine was twice that of putrescine. Their mode of cytotoxic action was similar, with both BA causing cell necrosis; they did not induce apoptosis. The present results may help in establishing legal limits for both putrescine and cadaverine in food

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