Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone

Methylone is a cathinone derivative that has recently emerged as a designer drug of abuse in Europe and the USA. Studies on the acute and long-term neurotoxicity of cathinones are starting to be conducted. We investigated the neurochemical/enzymatic changes indicative of neurotoxicity after methylon...

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Autores: López Arnau, Raúl, Martínez-Clemente, José, Pubill Sánchez, David, Escubedo Rafa, Elena, Camarasa García, Jordi
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/65530
Acceso en línea:https://hdl.handle.net/2445/65530
Access Level:acceso abierto
Palabra clave:Amfetamines
Neurotoxicologia
Sistema nerviós central
Hipocamp (Cervell)
Lòbul frontal
Rates (Animals de laboratori)
Trastorns de la memòria
Amphetamines
Neurotoxicology
Central nervous system
Hippocampus (Brain)
Frontal lobe
Rats as laboratory animals
Memory disorders
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repository_id_str
spelling Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methyloneLópez Arnau, RaúlMartínez-Clemente, JoséPubill Sánchez, DavidEscubedo Rafa, ElenaCamarasa García, JordiAmfetaminesNeurotoxicologiaSistema nerviós centralHipocamp (Cervell)Lòbul frontalRates (Animals de laboratori)Trastorns de la memòriaAmphetaminesNeurotoxicologyCentral nervous systemHippocampus (Brain)Frontal lobeRats as laboratory animalsMemory disordersMethylone is a cathinone derivative that has recently emerged as a designer drug of abuse in Europe and the USA. Studies on the acute and long-term neurotoxicity of cathinones are starting to be conducted. We investigated the neurochemical/enzymatic changes indicative of neurotoxicity after methylone administration (4 × 20 mg/kg, subcutaneously, per day with 3 h intervals) to adolescent rats, to model human recreational use. In addition, we studied the effect of methylone on spatial learning ad memory using the Morris water maze paradigm. Our experiments were carried out at a high ambient temperature to simulate the hot conditions found in dance clubs where the drug is consumed. We observed a hyperthermic response to methylone that reached a peak 30 min after each dose. We determined a serotonergic impairment in methylone-treated rats, especially in the frontal cortex, where it was accompanied by astrogliosis. Some serotonergic alterations were also present in the hippocampus and striatum. No significant neurotoxic effect on the dopaminergic system was identified. Methylone-treated animals only displayed impairments in the probe trial of the Morris water maze, which concerns reference memory, while the spatial learning process seemed to be preserved.Sage Publications2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/65530Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1177/0269881114548439Journal of Psychopharmacology, 2014, vol. 28, num. 11, p. 1053-1063http://dx.doi.org/10.1177/0269881114548439(c) López Arnau, Raúl et al., 2014info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/655302026-05-27T06:46:51Z
dc.title.none.fl_str_mv Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
title Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
spellingShingle Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
López Arnau, Raúl
Amfetamines
Neurotoxicologia
Sistema nerviós central
Hipocamp (Cervell)
Lòbul frontal
Rates (Animals de laboratori)
Trastorns de la memòria
Amphetamines
Neurotoxicology
Central nervous system
Hippocampus (Brain)
Frontal lobe
Rats as laboratory animals
Memory disorders
title_short Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
title_full Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
title_fullStr Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
title_full_unstemmed Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
title_sort Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
dc.creator.none.fl_str_mv López Arnau, Raúl
Martínez-Clemente, José
Pubill Sánchez, David
Escubedo Rafa, Elena
Camarasa García, Jordi
author López Arnau, Raúl
author_facet López Arnau, Raúl
Martínez-Clemente, José
Pubill Sánchez, David
Escubedo Rafa, Elena
Camarasa García, Jordi
author_role author
author2 Martínez-Clemente, José
Pubill Sánchez, David
Escubedo Rafa, Elena
Camarasa García, Jordi
author2_role author
author
author
author
dc.subject.none.fl_str_mv Amfetamines
Neurotoxicologia
Sistema nerviós central
Hipocamp (Cervell)
Lòbul frontal
Rates (Animals de laboratori)
Trastorns de la memòria
Amphetamines
Neurotoxicology
Central nervous system
Hippocampus (Brain)
Frontal lobe
Rats as laboratory animals
Memory disorders
topic Amfetamines
Neurotoxicologia
Sistema nerviós central
Hipocamp (Cervell)
Lòbul frontal
Rates (Animals de laboratori)
Trastorns de la memòria
Amphetamines
Neurotoxicology
Central nervous system
Hippocampus (Brain)
Frontal lobe
Rats as laboratory animals
Memory disorders
description Methylone is a cathinone derivative that has recently emerged as a designer drug of abuse in Europe and the USA. Studies on the acute and long-term neurotoxicity of cathinones are starting to be conducted. We investigated the neurochemical/enzymatic changes indicative of neurotoxicity after methylone administration (4 × 20 mg/kg, subcutaneously, per day with 3 h intervals) to adolescent rats, to model human recreational use. In addition, we studied the effect of methylone on spatial learning ad memory using the Morris water maze paradigm. Our experiments were carried out at a high ambient temperature to simulate the hot conditions found in dance clubs where the drug is consumed. We observed a hyperthermic response to methylone that reached a peak 30 min after each dose. We determined a serotonergic impairment in methylone-treated rats, especially in the frontal cortex, where it was accompanied by astrogliosis. Some serotonergic alterations were also present in the hippocampus and striatum. No significant neurotoxic effect on the dopaminergic system was identified. Methylone-treated animals only displayed impairments in the probe trial of the Morris water maze, which concerns reference memory, while the spatial learning process seemed to be preserved.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/65530
url https://hdl.handle.net/2445/65530
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1177/0269881114548439
Journal of Psychopharmacology, 2014, vol. 28, num. 11, p. 1053-1063
http://dx.doi.org/10.1177/0269881114548439
dc.rights.none.fl_str_mv (c) López Arnau, Raúl et al., 2014
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) López Arnau, Raúl et al., 2014
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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