Genome-wide patterns of homozygosity provide clues about the population history and adaptation of goats
Background: Patterns of homozygosity can be influenced by several factors, such as demography, recombination, and selection. Using the goat SNP50 BeadChip, we genotyped 3171 goats belonging to 117 populations with a worldwide distribution. Our objectives were to characterize the number and length of...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:218125 |
| Acceso en línea: | https://ddd.uab.cat/record/218125 https://dx.doi.org/urn:doi:10.1186/s12711-018-0424-8 |
| Access Level: | acceso abierto |
| Palabra clave: | Acclimatization Animals Asia Breeding Genetic Variation Genetics, Population Genome Genomics Genotype Goats Homozygote Inbreeding Polymorphism, Single Nucleotide Population Density |
| Sumario: | Background: Patterns of homozygosity can be influenced by several factors, such as demography, recombination, and selection. Using the goat SNP50 BeadChip, we genotyped 3171 goats belonging to 117 populations with a worldwide distribution. Our objectives were to characterize the number and length of runs of homozygosity (ROH) and to detect ROH hotspots in order to gain new insights into the consequences of neutral and selection processes on the genome-wide homozygosity patterns of goats. - Results: The proportion of the goat genome covered by ROH is, in general, less than 15% with an inverse relationship between ROH length and frequency i.e. short ROH (< 3 Mb) are the most frequent ones. Our data also indicate that ~ 60% of the breeds display low F coefficients (< 0.10), while ~ 30 and ~ 10% of the goat populations show moderate (0.10 < F < 0.20) or high (. |
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