Update of the risk assessment of nickel in food and drinking water
101 p.-5 fig.-16 tab.
| Autores: | , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/229284 |
| Acceso en línea: | http://hdl.handle.net/10261/229284 |
| Access Level: | acceso abierto |
| Palabra clave: | Nickel Tolerable daily intake (TDI) Margin of exposure (MOE) Food Dietary exposure Sensitisation Toxicity |
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Update of the risk assessment of nickel in food and drinking water |
| title |
Update of the risk assessment of nickel in food and drinking water |
| spellingShingle |
Update of the risk assessment of nickel in food and drinking water EFSA CONTAM Panel Nickel Tolerable daily intake (TDI) Margin of exposure (MOE) Food Dietary exposure Sensitisation Toxicity |
| title_short |
Update of the risk assessment of nickel in food and drinking water |
| title_full |
Update of the risk assessment of nickel in food and drinking water |
| title_fullStr |
Update of the risk assessment of nickel in food and drinking water |
| title_full_unstemmed |
Update of the risk assessment of nickel in food and drinking water |
| title_sort |
Update of the risk assessment of nickel in food and drinking water |
| dc.creator.none.fl_str_mv |
EFSA CONTAM Panel Schrenk, Dieter Bignami, Margherita Bodin, Laurent Chipman, James Kevin Del Mazo, Jesús Grasl-Kraupp, Bettina Hogstrand, Christer Hoogenboom, Laurentius (Ron) Leblanc, Jean-Charles Nebbia, Carlo Stefano Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Guérin, Thierry Massanyi, Peter van Loveren, Henk Baert, Katleen Gergelova, Petra Nielsen, Elsa |
| author |
EFSA CONTAM Panel |
| author_facet |
EFSA CONTAM Panel Schrenk, Dieter Bignami, Margherita Bodin, Laurent Chipman, James Kevin Del Mazo, Jesús Grasl-Kraupp, Bettina Hogstrand, Christer Hoogenboom, Laurentius (Ron) Leblanc, Jean-Charles Nebbia, Carlo Stefano Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Guérin, Thierry Massanyi, Peter van Loveren, Henk Baert, Katleen Gergelova, Petra Nielsen, Elsa |
| author_role |
author |
| author2 |
Schrenk, Dieter Bignami, Margherita Bodin, Laurent Chipman, James Kevin Del Mazo, Jesús Grasl-Kraupp, Bettina Hogstrand, Christer Hoogenboom, Laurentius (Ron) Leblanc, Jean-Charles Nebbia, Carlo Stefano Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Guérin, Thierry Massanyi, Peter van Loveren, Henk Baert, Katleen Gergelova, Petra Nielsen, Elsa |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Commission Schrenk, Dieter [0000-0002-7717-5533] Bignami, Margherita [0000-0002-1525-6864] Bodin, Laurent [0000-0001-5671-3139] Del Mazo, Jesús [0000-0003-3269-3895] Grasl-Kraupp, Bettina [0000-0003-4889-6531] Hogstrand, Christer [0000-0001-7545-6975] Hoogenboom, Laurentius (Ron) [0000-0002-8913-5328] Leblanc, Jean-Charles [0000-0003-2872-3414] Ntzani, Evangelia [0000-0003-3712-4181] Sand, Salomon [0000-0002-3360-0534] Schwerdtle, Tanja [0000-0002-4873-7488] Vleminckx, Christiane [0000-0002-9928-1601] Guérin, Thierry [0000-0003-4060-6616] Massanyi, Peter [0000-0002-4216-0948] van Loveren, Henk [0000-0002-1805-6198] Nielsen, Elsa [0000-0002-6874-2575] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Nickel Tolerable daily intake (TDI) Margin of exposure (MOE) Food Dietary exposure Sensitisation Toxicity |
| topic |
Nickel Tolerable daily intake (TDI) Margin of exposure (MOE) Food Dietary exposure Sensitisation Toxicity |
| description |
101 p.-5 fig.-16 tab. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/229284 |
| url |
http://hdl.handle.net/10261/229284 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
EFSA CONTAM Panel; Schrenk, Dieter; Bignami, Margherita; Bodin, Laurent; Chipman, James Kevin; Del Mazo, Jesús; Grasl-Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius (Ron); Leblanc, Jean-Charles; Nebbia, Carlo Stefano; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Schwerdtle, Tanja; Vleminckx, Christiane; Wallace, Heather; Guérin, Thierry; Massanyi, Peter; van Loveren, Henk; Baert, Katleen; Gergelova, Petra; Nielsen, Elsa; 2020; Occurrence data on nickel in food [Dataset]; Zenodo; Version 1; https://doi.org/10.5281/zenodo.4071465 EFSA CONTAM Panel; Schrenk, Dieter; Bignami, Margherita; Bodin, Laurent; Chipman, James Kevin; Del Mazo, Jesús; Grasl-Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius (Ron); Leblanc, Jean-Charles; Nebbia, Carlo Stefano; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Schwerdtle, Tanja; Vleminckx, Christiane; Wallace, Heather; Guérin, Thierry; Massanyi, Peter; van Loveren, Henk; Baert, Katleen; Gergelova, Petra; Nielsen, Elsa; 2020; Annexes to the Update of the risk assessment of nickel in food and drinking water [Dataset]; Zenodo; Version 1; https://doi.org/10.5281/zenodo.4081872 https://doi.org/10.2903/j.efsa.2020.6268 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
John Wiley & Sons |
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John Wiley & Sons |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869413168672931840 |
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Update of the risk assessment of nickel in food and drinking waterEFSA CONTAM PanelSchrenk, DieterBignami, MargheritaBodin, LaurentChipman, James KevinDel Mazo, JesúsGrasl-Kraupp, BettinaHogstrand, ChristerHoogenboom, Laurentius (Ron)Leblanc, Jean-CharlesNebbia, Carlo StefanoNtzani, EvangeliaPetersen, AnnetteSand, SalomonSchwerdtle, TanjaVleminckx, ChristianeWallace, HeatherGuérin, ThierryMassanyi, Petervan Loveren, HenkBaert, KatleenGergelova, PetraNielsen, ElsaNickelTolerable daily intake (TDI)Margin of exposure (MOE)FoodDietary exposureSensitisationToxicity101 p.-5 fig.-16 tab.The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of post‐implantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 μg/kg bw. Eczematous flare‐up reactions in the skin elicited in nickel‐sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest‐observed‐adverse‐effect‐level of 4.3 μg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel‐sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.The Panel wishes to thank the following for the support provided to this scientific output: Elena Rovesti. The Panel wishes to acknowledge all European competent institutions,Member State bodies and other organisations that provided data for this scientific output.Peer reviewedJohn Wiley & SonsEuropean CommissionSchrenk, Dieter [0000-0002-7717-5533]Bignami, Margherita [0000-0002-1525-6864]Bodin, Laurent [0000-0001-5671-3139]Del Mazo, Jesús [0000-0003-3269-3895]Grasl-Kraupp, Bettina [0000-0003-4889-6531]Hogstrand, Christer [0000-0001-7545-6975]Hoogenboom, Laurentius (Ron) [0000-0002-8913-5328]Leblanc, Jean-Charles [0000-0003-2872-3414]Ntzani, Evangelia [0000-0003-3712-4181]Sand, Salomon [0000-0002-3360-0534]Schwerdtle, Tanja [0000-0002-4873-7488]Vleminckx, Christiane [0000-0002-9928-1601]Guérin, Thierry [0000-0003-4060-6616]Massanyi, Peter [0000-0002-4216-0948]van Loveren, Henk [0000-0002-1805-6198]Nielsen, Elsa [0000-0002-6874-2575]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/229284reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésEFSA CONTAM Panel; Schrenk, Dieter; Bignami, Margherita; Bodin, Laurent; Chipman, James Kevin; Del Mazo, Jesús; Grasl-Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius (Ron); Leblanc, Jean-Charles; Nebbia, Carlo Stefano; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Schwerdtle, Tanja; Vleminckx, Christiane; Wallace, Heather; Guérin, Thierry; Massanyi, Peter; van Loveren, Henk; Baert, Katleen; Gergelova, Petra; Nielsen, Elsa; 2020; Occurrence data on nickel in food [Dataset]; Zenodo; Version 1; https://doi.org/10.5281/zenodo.4071465EFSA CONTAM Panel; Schrenk, Dieter; Bignami, Margherita; Bodin, Laurent; Chipman, James Kevin; Del Mazo, Jesús; Grasl-Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius (Ron); Leblanc, Jean-Charles; Nebbia, Carlo Stefano; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Schwerdtle, Tanja; Vleminckx, Christiane; Wallace, Heather; Guérin, Thierry; Massanyi, Peter; van Loveren, Henk; Baert, Katleen; Gergelova, Petra; Nielsen, Elsa; 2020; Annexes to the Update of the risk assessment of nickel in food and drinking water [Dataset]; Zenodo; Version 1; https://doi.org/10.5281/zenodo.4081872https://doi.org/10.2903/j.efsa.2020.6268Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2292842026-05-22T06:33:51Z |
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15,811543 |