A highly sensitive microsystem based on nanomechanical biosensors for genomics applications

9 páginas, 13 figuras, 1 tabla.-- PDF pre-print.-- et al.

Bibliographic Details
Authors: Lechuga, Laura M., Tamayo de Miguel, Francisco Javier, Álvarez, Mar, Carrascosa, Laura G., Yúfera, Alberto, Rueda, Adoración, Plaza, José Antonio, Zinoviev, Kirill, Domínguez-Matas, Carlos, Zaballos, Ángel, Moreno, M., Martínez-Alonso, Carlos, Díaz, Vicente, Bernad, Antonio
Format: article
Publication Date:2006
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/27936
Online Access:http://hdl.handle.net/10261/27936
Access Level:Open access
Keyword:Biosensors
Microsystem
Si technology
Microcantilevers
DNA biochip
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spelling A highly sensitive microsystem based on nanomechanical biosensors for genomics applicationsLechuga, Laura M.Tamayo de Miguel, Francisco JavierÁlvarez, MarCarrascosa, Laura G.Yúfera, AlbertoRueda, AdoraciónPlaza, José AntonioZinoviev, KirillDomínguez-Matas, CarlosZaballos, ÁngelMoreno, M.Martínez-Alonso, CarlosDíaz, VicenteBernad, AntonioBiosensorsMicrosystemSi technologyMicrocantileversDNA biochip9 páginas, 13 figuras, 1 tabla.-- PDF pre-print.-- et al.Microcantilever-based biosensors are a promising tool to detect biomolecular interactions in a direct way with high accuracy. We show the development of a portable biosensor microsystem able to detect nucleic acid hybridization with high sensitivity. The microsystem comprises an array of 20 micromechanical cantilevers produced in silicon technology, a polymer microfluidic system for delivery of the samples, an array of 20 vertical cavity surface emitting lasers (VCSELs) with collimated beams thanks to an integrated microlens array, an optical coupling element to provide the optical path required, and chips with the photodetectors and the CMOS circuitry for signal acquisition and conditioning, capable of measuring the cantilever deflection with sub-nanometer resolution. Robust immobilization and regeneration procedures have been implemented for the oligonucleotide receptor sequences. In a further innovation, an optical waveguide cantilever transducer has been also developed in order to improve the final performance of the device. This has a number of advantages in terms of a simple optical geometry and improved sensitivity.This work is being supported by the EU Contract IST-2001-37239. Spanish authors are also supported by national project TIC2002-10473-E.Peer reviewedElsevier201020102006info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501243984 bytesapplication/pdfhttp://hdl.handle.net/10261/27936reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.snb.2006.04.017info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/279362026-05-22T06:33:51Z
dc.title.none.fl_str_mv A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
title A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
spellingShingle A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
Lechuga, Laura M.
Biosensors
Microsystem
Si technology
Microcantilevers
DNA biochip
title_short A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
title_full A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
title_fullStr A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
title_full_unstemmed A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
title_sort A highly sensitive microsystem based on nanomechanical biosensors for genomics applications
dc.creator.none.fl_str_mv Lechuga, Laura M.
Tamayo de Miguel, Francisco Javier
Álvarez, Mar
Carrascosa, Laura G.
Yúfera, Alberto
Rueda, Adoración
Plaza, José Antonio
Zinoviev, Kirill
Domínguez-Matas, Carlos
Zaballos, Ángel
Moreno, M.
Martínez-Alonso, Carlos
Díaz, Vicente
Bernad, Antonio
author Lechuga, Laura M.
author_facet Lechuga, Laura M.
Tamayo de Miguel, Francisco Javier
Álvarez, Mar
Carrascosa, Laura G.
Yúfera, Alberto
Rueda, Adoración
Plaza, José Antonio
Zinoviev, Kirill
Domínguez-Matas, Carlos
Zaballos, Ángel
Moreno, M.
Martínez-Alonso, Carlos
Díaz, Vicente
Bernad, Antonio
author_role author
author2 Tamayo de Miguel, Francisco Javier
Álvarez, Mar
Carrascosa, Laura G.
Yúfera, Alberto
Rueda, Adoración
Plaza, José Antonio
Zinoviev, Kirill
Domínguez-Matas, Carlos
Zaballos, Ángel
Moreno, M.
Martínez-Alonso, Carlos
Díaz, Vicente
Bernad, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biosensors
Microsystem
Si technology
Microcantilevers
DNA biochip
topic Biosensors
Microsystem
Si technology
Microcantilevers
DNA biochip
description 9 páginas, 13 figuras, 1 tabla.-- PDF pre-print.-- et al.
publishDate 2006
dc.date.none.fl_str_mv 2006
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/27936
url http://hdl.handle.net/10261/27936
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.snb.2006.04.017
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 243984 bytes
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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