Lineage decision-making within normal haematopoietic and leukemic stem cells

This article belongs to the Special Issue Cellular and Molecular Mechanisms of Hematopoiesis.

Detalles Bibliográficos
Autores: Brown, Geoffrey, Sánchez, Lucía, Sánchez García, Isidro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/222920
Acceso en línea:http://hdl.handle.net/10261/222920
Access Level:acceso abierto
Palabra clave:Leukaemia
Lineage decision making
Stem cells
Haematopoiesis
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spelling Lineage decision-making within normal haematopoietic and leukemic stem cellsBrown, GeoffreySánchez, LucíaSánchez García, IsidroLeukaemiaLineage decision makingStem cellsHaematopoiesisThis article belongs to the Special Issue Cellular and Molecular Mechanisms of Hematopoiesis.To produce the wide range of blood and immune cell types, haematopoietic stem cells can “choose” directly from the entire spectrum of blood cell fate-options. Affiliation to a single cell lineage can occur at the level of the haematopoietic stem cell and these cells are therefore a mixture of some pluripotent cells and many cells with lineage signatures. Even so, haematopoietic stem cells and their progeny that have chosen a particular fate can still “change their mind” and adopt a different developmental pathway. Many of the leukaemias arise in haematopoietic stem cells with the bulk of the often partially differentiated leukaemia cells belonging to just one cell type. We argue that the reason for this is that an oncogenic insult to the genome “hard wires” leukaemia stem cells, either through development or at some stage, to one cell lineage. Unlike normal haematopoietic stem cells, oncogene-transformed leukaemia stem cells and their progeny are unable to adopt an alternative pathway.This project received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 315902. Research in ISG group is partially supported by SAF2015-64420-R MINECO/FEDER,UE, RTI2018-093314-B-I00 MCIU/AEI/FEDER,UE, by Junta de Castilla y León (UIC-017, CSI001U16, and CSI234P18), by the German Carreras Foundation (DJCLS 02R-2016; DJCLS 07R/2019) and by the German Federal Office for Radiation Protection (BfS)-Germany (FKZ: 3618S32274), and by the Fundacion Unoentrecienmil (CUNINA project).Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionMinisterio de Economía y Competitividad (España)Junta de Castilla y LeónAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Friends of José Carreras International Leukemia FoundationFundación UnoentrecienmilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/222920reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/315902SAF2015-64420-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093314-B-I00RTI2018-093314-B-I00/AEI/10.13039/501100011033https://doi.org/10.3390/ijms21062247Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2229202026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lineage decision-making within normal haematopoietic and leukemic stem cells
title Lineage decision-making within normal haematopoietic and leukemic stem cells
spellingShingle Lineage decision-making within normal haematopoietic and leukemic stem cells
Brown, Geoffrey
Leukaemia
Lineage decision making
Stem cells
Haematopoiesis
title_short Lineage decision-making within normal haematopoietic and leukemic stem cells
title_full Lineage decision-making within normal haematopoietic and leukemic stem cells
title_fullStr Lineage decision-making within normal haematopoietic and leukemic stem cells
title_full_unstemmed Lineage decision-making within normal haematopoietic and leukemic stem cells
title_sort Lineage decision-making within normal haematopoietic and leukemic stem cells
dc.creator.none.fl_str_mv Brown, Geoffrey
Sánchez, Lucía
Sánchez García, Isidro
author Brown, Geoffrey
author_facet Brown, Geoffrey
Sánchez, Lucía
Sánchez García, Isidro
author_role author
author2 Sánchez, Lucía
Sánchez García, Isidro
author2_role author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Economía y Competitividad (España)
Junta de Castilla y León
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Friends of José Carreras International Leukemia Foundation
Fundación Unoentrecienmil
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Leukaemia
Lineage decision making
Stem cells
Haematopoiesis
topic Leukaemia
Lineage decision making
Stem cells
Haematopoiesis
description This article belongs to the Special Issue Cellular and Molecular Mechanisms of Hematopoiesis.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/222920
url http://hdl.handle.net/10261/222920
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/315902
SAF2015-64420-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093314-B-I00
RTI2018-093314-B-I00/AEI/10.13039/501100011033
https://doi.org/10.3390/ijms21062247
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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