Assessment of the greenness of molecularly imprinted polymers used in sample preparation

It is now widely accepted that the incorporation of molecularly imprinted polymers (MIPs) into sample preparation techniques has enabled unprecedented selectivity performance of analytical methods for the determination of a wide range of analytes in biological, food and environmental samples. Howeve...

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Detalhes bibliográficos
Autores: Marć, Mariusz, Martín Esteban, Antonio
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/395299
Acesso em linha:http://hdl.handle.net/10261/395299
https://api.elsevier.com/content/abstract/scopus_id/86000180560
Access Level:acceso abierto
Palavra-chave:AGREEMIP
Green metrics
Molecularly imprinted polymers
Sample preparation
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spelling Assessment of the greenness of molecularly imprinted polymers used in sample preparationMarć, MariuszMartín Esteban, AntonioAGREEMIPGreen metricsMolecularly imprinted polymersSample preparationIt is now widely accepted that the incorporation of molecularly imprinted polymers (MIPs) into sample preparation techniques has enabled unprecedented selectivity performance of analytical methods for the determination of a wide range of analytes in biological, food and environmental samples. However, according to the Principles of Green Chemistry and the subsequent Principles of Green Sample Preparation, it is clear that MIPs are far from being considered green materials, both due to the common harmful reagents and the experimental conditions used for their synthesis. Accordingly, new greener routes for MIP synthesis have been proposed in recent years. However, although the titles of some of the published papers include terms such as 'green MIP' or 'sustainable MIP', such improved properties have only been assessed intuitively and it is therefore unclear whether such claimed green or sustainable MIPs are actually so. Therefore, in the present review, published papers using apparently green MIPs in sample preparation were evaluated using the recently developed metric tool AGREEMIP. Such a tool is based on the assessment of 12 criteria related to the greenness of the different reagents used, energy requirements and other aspects of MIP synthesis procedures. The final values of performed AGREEMIP assessment ranged from 0.28 to 0.80. The scores obtained after the AGREEMIP assessment clearly show that, although slight improvements have been achieved in terms of greenness, there is an abuse of the use of green-related terms and further development is needed. In this context, some guidelines for greening MIPs are provided.Grant PID2021–122327OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” is gratefully acknowledged. Financial support of these studies from Gdansk University of Technology by the DEC-6/1/2024/IDUB/II.1b/Am grant under the Americium International Career Development - ‘Excellence Initiative - Research University’ program is gratefully acknowledged. This article is based upon work from the Sample Preparation Study Group and Network, supported by the Division of Analytical Chemistry of the European Chemical Society.Peer reviewedElsevier BVMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)European CommissionGdańsk University of TechnologyMartín Esteban, Antonio [0000-0003-0498-5153]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/395299https://api.elsevier.com/content/abstract/scopus_id/86000180560reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122327OB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1016/j.sampre.2025.100167https://doi.org/10.1016/j.sampre.2025.100167Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3952992026-05-22T06:33:51Z
dc.title.none.fl_str_mv Assessment of the greenness of molecularly imprinted polymers used in sample preparation
title Assessment of the greenness of molecularly imprinted polymers used in sample preparation
spellingShingle Assessment of the greenness of molecularly imprinted polymers used in sample preparation
Marć, Mariusz
AGREEMIP
Green metrics
Molecularly imprinted polymers
Sample preparation
title_short Assessment of the greenness of molecularly imprinted polymers used in sample preparation
title_full Assessment of the greenness of molecularly imprinted polymers used in sample preparation
title_fullStr Assessment of the greenness of molecularly imprinted polymers used in sample preparation
title_full_unstemmed Assessment of the greenness of molecularly imprinted polymers used in sample preparation
title_sort Assessment of the greenness of molecularly imprinted polymers used in sample preparation
dc.creator.none.fl_str_mv Marć, Mariusz
Martín Esteban, Antonio
author Marć, Mariusz
author_facet Marć, Mariusz
Martín Esteban, Antonio
author_role author
author2 Martín Esteban, Antonio
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
European Commission
Gdańsk University of Technology
Martín Esteban, Antonio [0000-0003-0498-5153]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv AGREEMIP
Green metrics
Molecularly imprinted polymers
Sample preparation
topic AGREEMIP
Green metrics
Molecularly imprinted polymers
Sample preparation
description It is now widely accepted that the incorporation of molecularly imprinted polymers (MIPs) into sample preparation techniques has enabled unprecedented selectivity performance of analytical methods for the determination of a wide range of analytes in biological, food and environmental samples. However, according to the Principles of Green Chemistry and the subsequent Principles of Green Sample Preparation, it is clear that MIPs are far from being considered green materials, both due to the common harmful reagents and the experimental conditions used for their synthesis. Accordingly, new greener routes for MIP synthesis have been proposed in recent years. However, although the titles of some of the published papers include terms such as 'green MIP' or 'sustainable MIP', such improved properties have only been assessed intuitively and it is therefore unclear whether such claimed green or sustainable MIPs are actually so. Therefore, in the present review, published papers using apparently green MIPs in sample preparation were evaluated using the recently developed metric tool AGREEMIP. Such a tool is based on the assessment of 12 criteria related to the greenness of the different reagents used, energy requirements and other aspects of MIP synthesis procedures. The final values of performed AGREEMIP assessment ranged from 0.28 to 0.80. The scores obtained after the AGREEMIP assessment clearly show that, although slight improvements have been achieved in terms of greenness, there is an abuse of the use of green-related terms and further development is needed. In this context, some guidelines for greening MIPs are provided.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/395299
https://api.elsevier.com/content/abstract/scopus_id/86000180560
url http://hdl.handle.net/10261/395299
https://api.elsevier.com/content/abstract/scopus_id/86000180560
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122327OB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1016/j.sampre.2025.100167
https://doi.org/10.1016/j.sampre.2025.100167
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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