Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex

During economic choice, options are often considered in alternation, until commitment. Nonetheless, neuroeconomics typically ignores the dynamic aspects of deliberation. We trained two male macaques to perform a value-based decision-making task in which two risky offers were presented in sequence at...

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Autores: Ferro, Demetrio, Cash-Padgett, Tyler, Wang, Maya Zhe, Hayden, Benjamin Y., Moreno-Bote, Ruben
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/70699
Acceso en línea:http://hdl.handle.net/10230/70699
http://dx.doi.org/10.1038/s41467-024-50214-2
Access Level:acceso abierto
Palabra clave:Escorça cerebral
Decisió, Presa de
Animals -- Presa de decisions
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spelling Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortexFerro, DemetrioCash-Padgett, TylerWang, Maya ZheHayden, Benjamin Y.Moreno-Bote, RubenEscorça cerebralDecisió, Presa deAnimals -- Presa de decisionsDuring economic choice, options are often considered in alternation, until commitment. Nonetheless, neuroeconomics typically ignores the dynamic aspects of deliberation. We trained two male macaques to perform a value-based decision-making task in which two risky offers were presented in sequence at the opposite sides of the visual field, each followed by a delay epoch where offers were invisible. Surprisingly, during the two delays, subjects tend to look at empty locations where the offers had previously appeared, with longer fixations increasing the probability of choosing the associated offer. Spiking activity in orbitofrontal cortex reflects the value of the gazed offer, or of the offer associated with the gazed empty spatial location, even if it is not the most recent. This reactivation reflects a reevaluation process, as fluctuations in neural spiking correlate with upcoming choice. Our results suggest that look-at-nothing gazing triggers the reactivation of a previously seen offer for further evaluation.We appreciate Ramon Nogueira for discussion about core methods. This project was supported by grants from the Howard Hughes Medical Institute (HHMI; Ref: 55008742), The Bial Foundation (Ref: 106/2022), Ministerio de Ciencia e Innovación (Ref: PID2020-114196GB-I00/AEI) and ICREA Academia (2022) to R.M.B.Nature Research202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70699http://dx.doi.org/10.1038/s41467-024-50214-2reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNature Communications. 2024;15:6163info:eu-repo/grantAgreement/ES/2PE/PID2020-114196GB-I00© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/706992026-06-12T07:21:37Z
dc.title.none.fl_str_mv Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
title Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
spellingShingle Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
Ferro, Demetrio
Escorça cerebral
Decisió, Presa de
Animals -- Presa de decisions
title_short Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
title_full Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
title_fullStr Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
title_full_unstemmed Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
title_sort Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
dc.creator.none.fl_str_mv Ferro, Demetrio
Cash-Padgett, Tyler
Wang, Maya Zhe
Hayden, Benjamin Y.
Moreno-Bote, Ruben
author Ferro, Demetrio
author_facet Ferro, Demetrio
Cash-Padgett, Tyler
Wang, Maya Zhe
Hayden, Benjamin Y.
Moreno-Bote, Ruben
author_role author
author2 Cash-Padgett, Tyler
Wang, Maya Zhe
Hayden, Benjamin Y.
Moreno-Bote, Ruben
author2_role author
author
author
author
dc.subject.none.fl_str_mv Escorça cerebral
Decisió, Presa de
Animals -- Presa de decisions
topic Escorça cerebral
Decisió, Presa de
Animals -- Presa de decisions
description During economic choice, options are often considered in alternation, until commitment. Nonetheless, neuroeconomics typically ignores the dynamic aspects of deliberation. We trained two male macaques to perform a value-based decision-making task in which two risky offers were presented in sequence at the opposite sides of the visual field, each followed by a delay epoch where offers were invisible. Surprisingly, during the two delays, subjects tend to look at empty locations where the offers had previously appeared, with longer fixations increasing the probability of choosing the associated offer. Spiking activity in orbitofrontal cortex reflects the value of the gazed offer, or of the offer associated with the gazed empty spatial location, even if it is not the most recent. This reactivation reflects a reevaluation process, as fluctuations in neural spiking correlate with upcoming choice. Our results suggest that look-at-nothing gazing triggers the reactivation of a previously seen offer for further evaluation.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/70699
http://dx.doi.org/10.1038/s41467-024-50214-2
url http://hdl.handle.net/10230/70699
http://dx.doi.org/10.1038/s41467-024-50214-2
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nature Communications. 2024;15:6163
info:eu-repo/grantAgreement/ES/2PE/PID2020-114196GB-I00
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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