Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death

Producción Científica

Detalles Bibliográficos
Autores: Rodríguez, Juan Pablo, Guijas Maté, Carlos, Astudillo del Valle, Alma María, Rubio, Julio M., Balboa García, María Ángeles, Balsinde Rodríguez, Jesús
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/55994
Acceso en línea:https://doi.org/10.3390/cancers11040524
https://uvadoc.uva.es/handle/10324/55994
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Cáncer colorrectal
Hydroxystearic acid
Ácido hidroxiesteárico
Apoptosis
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spelling Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell deathRodríguez, Juan PabloGuijas Maté, CarlosAstudillo del Valle, Alma MaríaRubio, Julio M.Balboa García, María ÁngelesBalsinde Rodríguez, JesúsColorectal cancerCáncer colorrectalHydroxystearic acidÁcido hidroxiesteáricoApoptosisProducción CientíficaHydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through mechanisms involving different targets. Using mass spectrometry-based lipidomic approaches, we show in this study that 9-HSA levels in human colorectal tumors are diminished when compared with normal adjacent tissue. Since this decrease could be compatible with an escape mechanism of tumors from 9-HSA-induced apoptosis, we investigated different features of the utilization of this hydroxyfatty acid in colon. We show that in colorectal tumors and related cell lines such as HT-29 and HCT-116, 9-HSA is the only hydroxyfatty acid constituent of branched fatty acid esters of hydroxyfatty acids (FAHFA), a novel family of lipids with anti-inflammatory properties. Importantly, FAHFA levels in tumors are elevated compared with normal tissue and, unlike 9-HSA, they do not induce apoptosis of colorectal cell lines over a wide range of concentrations. Further, the addition of 9-HSA to colon cancer cell lines augments the synthesis of different FAHFA before the cells commit to apoptosis, suggesting that FAHFA formation may function as a buffer system that sequesters the hydroxyacid into an inactive form, thereby restricting apoptosis.Ministerio de Economía, Industria y Competitividad (projects SAF2016-80883-R and SAF2015-73000-EXP)MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/cancers11040524https://uvadoc.uva.es/handle/10324/55994reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2072-6694/11/4/524info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/559942026-06-13T12:44:47Z
dc.title.none.fl_str_mv Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
spellingShingle Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
Rodríguez, Juan Pablo
Colorectal cancer
Cáncer colorrectal
Hydroxystearic acid
Ácido hidroxiesteárico
Apoptosis
title_short Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_full Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_fullStr Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_full_unstemmed Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_sort Sequestration of 9-Hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
dc.creator.none.fl_str_mv Rodríguez, Juan Pablo
Guijas Maté, Carlos
Astudillo del Valle, Alma María
Rubio, Julio M.
Balboa García, María Ángeles
Balsinde Rodríguez, Jesús
author Rodríguez, Juan Pablo
author_facet Rodríguez, Juan Pablo
Guijas Maté, Carlos
Astudillo del Valle, Alma María
Rubio, Julio M.
Balboa García, María Ángeles
Balsinde Rodríguez, Jesús
author_role author
author2 Guijas Maté, Carlos
Astudillo del Valle, Alma María
Rubio, Julio M.
Balboa García, María Ángeles
Balsinde Rodríguez, Jesús
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Colorectal cancer
Cáncer colorrectal
Hydroxystearic acid
Ácido hidroxiesteárico
Apoptosis
topic Colorectal cancer
Cáncer colorrectal
Hydroxystearic acid
Ácido hidroxiesteárico
Apoptosis
description Producción Científica
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/cancers11040524
https://uvadoc.uva.es/handle/10324/55994
url https://doi.org/10.3390/cancers11040524
https://uvadoc.uva.es/handle/10324/55994
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2072-6694/11/4/524
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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