Sleep in the preclinical stages of Alzheimer's disease: a multimodal biomarkers approach
This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. However, the precise mechanisms linking sleep problems and AD pathophysiology...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/689587 |
| Acceso en línea: | http://hdl.handle.net/10803/689587 |
| Access Level: | acceso abierto |
| Palabra clave: | Sleep Preclinical Alzheimer’s disease CSF biomarkers Tau Neuroimaging Sueño Alzhéimer preclínico Biomarcadores del LCR Neuroimagen 616.8 |
| Sumario: | This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. However, the precise mechanisms linking sleep problems and AD pathophysiology remain elusive. This project seeks to address these gaps in knowledge by investigating how disrupted sleep impacts AD biomarkers and subsequent neurodegeneration. Using a multi-modal approach, the study examines the link between both subjective and objective sleep measures and various AD biomarkers, including cerebrospinal fluid markers and neuroimaging techniques like positron emission tomography (PET). The findings highlight that poor sleep quality in the preclinical stages of AD is closely tied to changes in core AD biomarkers, together with neuronal loss and synaptic dysfunction. Collectively, this research underscores the critical role of sleep in exacerbating AD pathology, even before clinical symptoms manifest. It emphasizes the importance of identifying sleep issues early and implementing tailored interventions to potentially delay or mitigate dementia's onset. |
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