Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes

Salbutamol is a bronchodilatator commonly used for the treatment of feline inflammatory lower airway disease, including asthma or acute bronchospasm. As in humans, a pressurized metered dose inhaler (pMDI) is used in conjunction with a spacer and a spherical mask to facilitate salbutamol administrat...

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Autores: Fernández-Parra, Rocío, Pey, Pascaline, Reinero, Carol, Malvè, Mauro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/46614
Acceso en línea:https://hdl.handle.net/2454/46614
Access Level:acceso abierto
Palabra clave:Bronchospasm
Computational fluid dynamics (CFD)
Feline
Inhalation therapy
Lower airway disease
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spelling Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizesFernández-Parra, RocíoPey, PascalineReinero, CarolMalvè, MauroBronchospasmComputational fluid dynamics (CFD)FelineInhalation therapyLower airway diseaseSalbutamol is a bronchodilatator commonly used for the treatment of feline inflammatory lower airway disease, including asthma or acute bronchospasm. As in humans, a pressurized metered dose inhaler (pMDI) is used in conjunction with a spacer and a spherical mask to facilitate salbutamol administration. However, efficacy of inhalation therapy is influenced by different factors including the noncooperative character of cats. In this study, the goal was to use computational fluid dynamics (CFD) to analyze the impact of breathing patterns and salbutamol particle size on overall drug transport and deposition using a specific spherical mask and spacer designed for cats. A model incorporating three-dimensional cat airway geometry, a commercially available spherical mask, and a 10  cm spacer, was used for CFD analysis. Two peak inspiratory flows were tested: 30  mL/s and 126  mL/s. Simulations were performed with 30s breathing different inspiratory and expiratory times, respiratory frequencies and peaks. Droplet spray transport and deposition were simulated with different particle sizes typical of the drug delivery therapies (1, 5, 10, and 15  μm). The percentage of particle deposition into the device and upper airways decreased with increasing particle diameter during both flows imposed in this cat model. During increased mean ventilatory rate (MVR) conditions, most of the salbutamol was lost in the upper airways. And during decreased MVR conditions, most of the particles remained in suspension (still in hold-up) between the mask and the carina, indicating the need for more than 30  s to be transported. In both flows the percentage of particles traveling to the lung was low at 1.5%–2.3%. In conclusion, in contrast to what has been described in the human literature, the results from this feline model suggest that the percentage of particles deposited on the upper airway decreases with increasing particle diameter.This study is supported by grants PID2021-125731OB-C31 and PID2021-125731OB-C33 from the Spanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033/ and FEDER (“A way to build Europe”).Frontiers MediaIngenieríaIngeniaritza2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/46614reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/AEI//PID2021-125731OB-C31info:eu-repo/grantAgreement/AEI//PID2021-125731OB-C33© 2023 Fernández-Parra, Pey, Reinero and Malvè. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/466142026-06-17T12:41:47Z
dc.title.none.fl_str_mv Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
title Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
spellingShingle Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
Fernández-Parra, Rocío
Bronchospasm
Computational fluid dynamics (CFD)
Feline
Inhalation therapy
Lower airway disease
title_short Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
title_full Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
title_fullStr Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
title_full_unstemmed Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
title_sort Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes
dc.creator.none.fl_str_mv Fernández-Parra, Rocío
Pey, Pascaline
Reinero, Carol
Malvè, Mauro
author Fernández-Parra, Rocío
author_facet Fernández-Parra, Rocío
Pey, Pascaline
Reinero, Carol
Malvè, Mauro
author_role author
author2 Pey, Pascaline
Reinero, Carol
Malvè, Mauro
author2_role author
author
author
dc.contributor.none.fl_str_mv Ingeniería
Ingeniaritza
dc.subject.none.fl_str_mv Bronchospasm
Computational fluid dynamics (CFD)
Feline
Inhalation therapy
Lower airway disease
topic Bronchospasm
Computational fluid dynamics (CFD)
Feline
Inhalation therapy
Lower airway disease
description Salbutamol is a bronchodilatator commonly used for the treatment of feline inflammatory lower airway disease, including asthma or acute bronchospasm. As in humans, a pressurized metered dose inhaler (pMDI) is used in conjunction with a spacer and a spherical mask to facilitate salbutamol administration. However, efficacy of inhalation therapy is influenced by different factors including the noncooperative character of cats. In this study, the goal was to use computational fluid dynamics (CFD) to analyze the impact of breathing patterns and salbutamol particle size on overall drug transport and deposition using a specific spherical mask and spacer designed for cats. A model incorporating three-dimensional cat airway geometry, a commercially available spherical mask, and a 10  cm spacer, was used for CFD analysis. Two peak inspiratory flows were tested: 30  mL/s and 126  mL/s. Simulations were performed with 30s breathing different inspiratory and expiratory times, respiratory frequencies and peaks. Droplet spray transport and deposition were simulated with different particle sizes typical of the drug delivery therapies (1, 5, 10, and 15  μm). The percentage of particle deposition into the device and upper airways decreased with increasing particle diameter during both flows imposed in this cat model. During increased mean ventilatory rate (MVR) conditions, most of the salbutamol was lost in the upper airways. And during decreased MVR conditions, most of the particles remained in suspension (still in hold-up) between the mask and the carina, indicating the need for more than 30  s to be transported. In both flows the percentage of particles traveling to the lung was low at 1.5%–2.3%. In conclusion, in contrast to what has been described in the human literature, the results from this feline model suggest that the percentage of particles deposited on the upper airway decreases with increasing particle diameter.
publishDate 2023
dc.date.none.fl_str_mv 2023
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info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/46614
url https://hdl.handle.net/2454/46614
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI//PID2021-125731OB-C31
info:eu-repo/grantAgreement/AEI//PID2021-125731OB-C33
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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instname_str Universidad Pública de Navarra
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