Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
Background: The earliest pathological features of Alzheimer’s disease (AD) appear decades before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal structural changes and functional visual alterations. Healthy individuals at high risk of developing AD present alte...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/72982 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/72982 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.894-053.9:612.84 617.7-073.75 616-07 Alzheimer's disease Magnetoencephalography Optical coherence tomography At risk for AD Visual function Oftalmología Optometría Óptica fisiológica Técnicas de la imagen 3201.09 Oftalmología 2209.15 Optometría |
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Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approachLópez Cuenca, InésNebreda Pérez, AlbertoGarcía Colomo, AlejandraGarcía Martín, Elena SalobrarDe Frutos Lucas, JaisalmerBruña Fernández, RicardoRamírez Sebastián, Ana IsabelRamírez Toraño, FedericoSalazar Corral, Juan JoséBarabash Bustelo, AnaGil Gregorio, PedroMaestu Unturbe, FernandoRamírez Sebastián, José ManuelHoz Montañana, María Rosa De616.894-053.9:612.84617.7-073.75616-07Alzheimer's diseaseMagnetoencephalographyOptical coherence tomographyAt risk for ADVisual functionOftalmologíaOptometríaÓptica fisiológicaTécnicas de la imagen3201.09 Oftalmología2209.15 OptometríaBackground: The earliest pathological features of Alzheimer’s disease (AD) appear decades before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal structural changes and functional visual alterations. Healthy individuals at high risk of developing AD present alterations in these ophthalmological measures, as well as in resting-state electrophysiological activity. However, it is unknown whether the ophthalmological alterations are related to the visual-related electrophysiological activity. Elucidating this relationship is paramount to understand the mechanisms underlying the early deterioration of the system and an important step in assessing the suitability of these measures as early biomarkers of disease. Methods: In total, 144 healthy subjects: 105 with family history of AD and 39 without, underwent ophthalmologic analysis, magnetoencephalography recording, and genotyping. A subdivision was made to compare groups with less demographic and more risk differences: 28 high-risk subjects (relatives/APOEɛ4 +) and 16 low-risk (non-relatives/APOEɛ4 −). Differences in visual acuity, contrast sensitivity, and macular thickness were evaluated. Correlations between each variable and visual-related electrophysiological measures (M100 latency and time–frequency power) were calculated for each group. Results: High-risk groups showed increased visual acuity. Visual acuity was also related to a lower M100 latency and a greater power time–frequency cluster in the high-risk group. Low-risk groups did not show this relationship. High-risk groups presented trends towards a greater contrast sensitivity that did not remain significant after correction for multiple comparisons. The highest-risk group showed trends towards the thinning of the inner plexiform and inner nuclear layers that did not remain significant after correction. The correlation between contrast sensitivity and macular thickness, and the electrophysiological measures were not significant after correction. The difference between the high- and low- risk groups correlations was no significant. Conclusions: To our knowledge, this paper is the first of its kind, assessing the relationship between ophthalmological and electrophysiological measures in healthy subjects at distinct levels of risk of AD. The results are novel and unexpected, showing an increase in visual acuity among high-risk subjects, who also exhibit a relationship between this measure and visual-related electrophysiological activity. These results have not been previously explored and could constitute a useful object of research as biomarkers for early detection and the evaluation of potential interventions’ effectiveness.BMC (Springer)Universidad Complutense de Madrid20232023-01-2320232023-01-23journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/72982reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/729822026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach |
| title |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach |
| spellingShingle |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach López Cuenca, Inés 616.894-053.9:612.84 617.7-073.75 616-07 Alzheimer's disease Magnetoencephalography Optical coherence tomography At risk for AD Visual function Oftalmología Optometría Óptica fisiológica Técnicas de la imagen 3201.09 Oftalmología 2209.15 Optometría |
| title_short |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach |
| title_full |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach |
| title_fullStr |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach |
| title_full_unstemmed |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach |
| title_sort |
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach |
| dc.creator.none.fl_str_mv |
López Cuenca, Inés Nebreda Pérez, Alberto García Colomo, Alejandra García Martín, Elena Salobrar De Frutos Lucas, Jaisalmer Bruña Fernández, Ricardo Ramírez Sebastián, Ana Isabel Ramírez Toraño, Federico Salazar Corral, Juan José Barabash Bustelo, Ana Gil Gregorio, Pedro Maestu Unturbe, Fernando Ramírez Sebastián, José Manuel Hoz Montañana, María Rosa De |
| author |
López Cuenca, Inés |
| author_facet |
López Cuenca, Inés Nebreda Pérez, Alberto García Colomo, Alejandra García Martín, Elena Salobrar De Frutos Lucas, Jaisalmer Bruña Fernández, Ricardo Ramírez Sebastián, Ana Isabel Ramírez Toraño, Federico Salazar Corral, Juan José Barabash Bustelo, Ana Gil Gregorio, Pedro Maestu Unturbe, Fernando Ramírez Sebastián, José Manuel Hoz Montañana, María Rosa De |
| author_role |
author |
| author2 |
Nebreda Pérez, Alberto García Colomo, Alejandra García Martín, Elena Salobrar De Frutos Lucas, Jaisalmer Bruña Fernández, Ricardo Ramírez Sebastián, Ana Isabel Ramírez Toraño, Federico Salazar Corral, Juan José Barabash Bustelo, Ana Gil Gregorio, Pedro Maestu Unturbe, Fernando Ramírez Sebastián, José Manuel Hoz Montañana, María Rosa De |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
616.894-053.9:612.84 617.7-073.75 616-07 Alzheimer's disease Magnetoencephalography Optical coherence tomography At risk for AD Visual function Oftalmología Optometría Óptica fisiológica Técnicas de la imagen 3201.09 Oftalmología 2209.15 Optometría |
| topic |
616.894-053.9:612.84 617.7-073.75 616-07 Alzheimer's disease Magnetoencephalography Optical coherence tomography At risk for AD Visual function Oftalmología Optometría Óptica fisiológica Técnicas de la imagen 3201.09 Oftalmología 2209.15 Optometría |
| description |
Background: The earliest pathological features of Alzheimer’s disease (AD) appear decades before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal structural changes and functional visual alterations. Healthy individuals at high risk of developing AD present alterations in these ophthalmological measures, as well as in resting-state electrophysiological activity. However, it is unknown whether the ophthalmological alterations are related to the visual-related electrophysiological activity. Elucidating this relationship is paramount to understand the mechanisms underlying the early deterioration of the system and an important step in assessing the suitability of these measures as early biomarkers of disease. Methods: In total, 144 healthy subjects: 105 with family history of AD and 39 without, underwent ophthalmologic analysis, magnetoencephalography recording, and genotyping. A subdivision was made to compare groups with less demographic and more risk differences: 28 high-risk subjects (relatives/APOEɛ4 +) and 16 low-risk (non-relatives/APOEɛ4 −). Differences in visual acuity, contrast sensitivity, and macular thickness were evaluated. Correlations between each variable and visual-related electrophysiological measures (M100 latency and time–frequency power) were calculated for each group. Results: High-risk groups showed increased visual acuity. Visual acuity was also related to a lower M100 latency and a greater power time–frequency cluster in the high-risk group. Low-risk groups did not show this relationship. High-risk groups presented trends towards a greater contrast sensitivity that did not remain significant after correction for multiple comparisons. The highest-risk group showed trends towards the thinning of the inner plexiform and inner nuclear layers that did not remain significant after correction. The correlation between contrast sensitivity and macular thickness, and the electrophysiological measures were not significant after correction. The difference between the high- and low- risk groups correlations was no significant. Conclusions: To our knowledge, this paper is the first of its kind, assessing the relationship between ophthalmological and electrophysiological measures in healthy subjects at distinct levels of risk of AD. The results are novel and unexpected, showing an increase in visual acuity among high-risk subjects, who also exhibit a relationship between this measure and visual-related electrophysiological activity. These results have not been previously explored and could constitute a useful object of research as biomarkers for early detection and the evaluation of potential interventions’ effectiveness. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-01-23 2023 2023-01-23 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/72982 |
| url |
https://hdl.handle.net/20.500.14352/72982 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
BMC (Springer) |
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BMC (Springer) |
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reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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