Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome

Down's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to the cognitive dysfunction in DS. Previously, we discovered that mTOR-dependent local translation, a pivotal process for some forms of synaptic plasticity, is deregulated in a...

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Detalles Bibliográficos
Autores: Andrade-Talavera, Yuniesky, Benito, Itziar, Casañas, Juan José, Rodríguez Moreno, Antonio, Montesinos Gutiérrez, María Luz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/107152
Acceso en línea:https://hdl.handle.net/11441/107152
https://doi.org/10.1016/j.nbd.2015.09.005
Access Level:acceso abierto
Palabra clave:Barnes maze
BDNF-LTP
ERK
MTOR
Pharmacotherapy
Synaptic plasticity
Trisomy 21
Ts1Cje
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repository_id_str
spelling Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndromeAndrade-Talavera, YunieskyBenito, ItziarCasañas, Juan JoséRodríguez Moreno, AntonioMontesinos Gutiérrez, María LuzBarnes mazeBDNF-LTPERKMTORPharmacotherapySynaptic plasticityTrisomy 21Ts1CjeDown's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to the cognitive dysfunction in DS. Previously, we discovered that mTOR-dependent local translation, a pivotal process for some forms of synaptic plasticity, is deregulated in a DS mouse model. Here, we report that these mice exhibit deficits in both synaptic plasticity (i.e., BDNF-long term potentiation) and the persistence of spatial long-term memory. Interestingly, these deficits were fully reversible using rapamycin, a Food and Drug Administration-approved specific mTOR inhibitor; therefore, rapamycin may be a novel pharmacotherapy to improve cognition in DS.ElsevierFisiología Médica y Biofísica2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/107152https://doi.org/10.1016/j.nbd.2015.09.005reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésNeurobiology Of Disease, 82, 516-525.https://www.sciencedirect.com/science/article/pii/S0969996115300528info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1071522026-06-17T12:51:07Z
dc.title.none.fl_str_mv Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
title Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
spellingShingle Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
Andrade-Talavera, Yuniesky
Barnes maze
BDNF-LTP
ERK
MTOR
Pharmacotherapy
Synaptic plasticity
Trisomy 21
Ts1Cje
title_short Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
title_full Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
title_fullStr Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
title_full_unstemmed Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
title_sort Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
dc.creator.none.fl_str_mv Andrade-Talavera, Yuniesky
Benito, Itziar
Casañas, Juan José
Rodríguez Moreno, Antonio
Montesinos Gutiérrez, María Luz
author Andrade-Talavera, Yuniesky
author_facet Andrade-Talavera, Yuniesky
Benito, Itziar
Casañas, Juan José
Rodríguez Moreno, Antonio
Montesinos Gutiérrez, María Luz
author_role author
author2 Benito, Itziar
Casañas, Juan José
Rodríguez Moreno, Antonio
Montesinos Gutiérrez, María Luz
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
dc.subject.none.fl_str_mv Barnes maze
BDNF-LTP
ERK
MTOR
Pharmacotherapy
Synaptic plasticity
Trisomy 21
Ts1Cje
topic Barnes maze
BDNF-LTP
ERK
MTOR
Pharmacotherapy
Synaptic plasticity
Trisomy 21
Ts1Cje
description Down's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to the cognitive dysfunction in DS. Previously, we discovered that mTOR-dependent local translation, a pivotal process for some forms of synaptic plasticity, is deregulated in a DS mouse model. Here, we report that these mice exhibit deficits in both synaptic plasticity (i.e., BDNF-long term potentiation) and the persistence of spatial long-term memory. Interestingly, these deficits were fully reversible using rapamycin, a Food and Drug Administration-approved specific mTOR inhibitor; therefore, rapamycin may be a novel pharmacotherapy to improve cognition in DS.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/107152
https://doi.org/10.1016/j.nbd.2015.09.005
url https://hdl.handle.net/11441/107152
https://doi.org/10.1016/j.nbd.2015.09.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neurobiology Of Disease, 82, 516-525.
https://www.sciencedirect.com/science/article/pii/S0969996115300528
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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