Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project
Background Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate th...
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/12093 |
| Acceso en línea: | http://hdl.handle.net/10902/12093 |
| Access Level: | acceso abierto |
| Palabra clave: | Rheumatoid arthritis Cardiovascular disease Lipoprotein(a) Biologics Tocilizumab |
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oai:repositorio.unican.es:10902/12093 |
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Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study ProjectGarcía Gómez, CarmenMartín Martínez, Maria A.Castañeda, SantosSanchez Alonso, FernandoUriarte Ecenarro, MirenGonzález Juanatey, CarlosRomera Baures, MontserratSantos Rey, JoséPinto Tasende, José AntonioQuesada Masachs, EstefaníaTornero Molina, JesúsMartínez González, OlgaCobo Ibáñez, TatianaChamizo Carmona, EugenioManrique Arija, SaraFábregas Canales, DoloresDíaz González, FedericoLlorca Díaz, Francisco Javier|||0000-0001-8569-861XGonzález-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406Rheumatoid arthritisCardiovascular diseaseLipoprotein(a)BiologicsTocilizumabBackground Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. Objective The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics. Methods Baseline analysis of the CARdiovascular in rheuMAtology project, a 10-year prospective study, evaluating the risk of cardiovascular events in RA and other forms of inflammatory arthritis. RA patients were classified according to treatment: no biologic, anti-tumor necrosis factor, anti-interleukin-6 receptor tocilizumab (TCZ), and other biologic (rituximab or abatacept). A model of linear multivariate regression was built in which the dependent variable was Lp(a) concentration and the explanatory variable was BT. The model was adjusted for confounding factors. Results Seven hundred and seventy-five RA patients were analyzed. Plasma concentrations of total cholesterol and triglyceride were significantly higher in TCZ-treated patients. Nevertheless, no significant difference in the atherogenic index between TCZ-treated patients and patients without BT was found. After adjusting for confounding factors, patients with BT had lower concentrations of Lp(a) than those without BT; however, only TCZ-treated patients achieved statistically significant differences (?: ?0.303, 95% confidence interval: ?0.558 to ?0.047; P = .02). Conclusions RA patients treated with TCZ show lower plasma concentrations of Lp(a) compared with patients without BT.This project has been supported by an unrestricted grant from Abbvie, Spain. The design, analysis, interpretation of results, and preparation of the article have been done independently of Abbvie. Dr González-Gay's studies have been supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII) (Spain).ElsevierUniversidad de Cantabria20172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/12093Journal of Clinical Lipidology (2017), Volume 11, Issue 3, May-June 2017, Pages 749-756.e3reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/120932026-06-02T12:39:31Z |
| dc.title.none.fl_str_mv |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project |
| title |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project |
| spellingShingle |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project García Gómez, Carmen Rheumatoid arthritis Cardiovascular disease Lipoprotein(a) Biologics Tocilizumab |
| title_short |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project |
| title_full |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project |
| title_fullStr |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project |
| title_full_unstemmed |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project |
| title_sort |
Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project |
| dc.creator.none.fl_str_mv |
García Gómez, Carmen Martín Martínez, Maria A. Castañeda, Santos Sanchez Alonso, Fernando Uriarte Ecenarro, Miren González Juanatey, Carlos Romera Baures, Montserrat Santos Rey, José Pinto Tasende, José Antonio Quesada Masachs, Estefanía Tornero Molina, Jesús Martínez González, Olga Cobo Ibáñez, Tatiana Chamizo Carmona, Eugenio Manrique Arija, Sara Fábregas Canales, Dolores Díaz González, Federico Llorca Díaz, Francisco Javier|||0000-0001-8569-861X González-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406 |
| author |
García Gómez, Carmen |
| author_facet |
García Gómez, Carmen Martín Martínez, Maria A. Castañeda, Santos Sanchez Alonso, Fernando Uriarte Ecenarro, Miren González Juanatey, Carlos Romera Baures, Montserrat Santos Rey, José Pinto Tasende, José Antonio Quesada Masachs, Estefanía Tornero Molina, Jesús Martínez González, Olga Cobo Ibáñez, Tatiana Chamizo Carmona, Eugenio Manrique Arija, Sara Fábregas Canales, Dolores Díaz González, Federico Llorca Díaz, Francisco Javier|||0000-0001-8569-861X González-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406 |
| author_role |
author |
| author2 |
Martín Martínez, Maria A. Castañeda, Santos Sanchez Alonso, Fernando Uriarte Ecenarro, Miren González Juanatey, Carlos Romera Baures, Montserrat Santos Rey, José Pinto Tasende, José Antonio Quesada Masachs, Estefanía Tornero Molina, Jesús Martínez González, Olga Cobo Ibáñez, Tatiana Chamizo Carmona, Eugenio Manrique Arija, Sara Fábregas Canales, Dolores Díaz González, Federico Llorca Díaz, Francisco Javier|||0000-0001-8569-861X González-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406 |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Rheumatoid arthritis Cardiovascular disease Lipoprotein(a) Biologics Tocilizumab |
| topic |
Rheumatoid arthritis Cardiovascular disease Lipoprotein(a) Biologics Tocilizumab |
| description |
Background Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. Objective The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics. Methods Baseline analysis of the CARdiovascular in rheuMAtology project, a 10-year prospective study, evaluating the risk of cardiovascular events in RA and other forms of inflammatory arthritis. RA patients were classified according to treatment: no biologic, anti-tumor necrosis factor, anti-interleukin-6 receptor tocilizumab (TCZ), and other biologic (rituximab or abatacept). A model of linear multivariate regression was built in which the dependent variable was Lp(a) concentration and the explanatory variable was BT. The model was adjusted for confounding factors. Results Seven hundred and seventy-five RA patients were analyzed. Plasma concentrations of total cholesterol and triglyceride were significantly higher in TCZ-treated patients. Nevertheless, no significant difference in the atherogenic index between TCZ-treated patients and patients without BT was found. After adjusting for confounding factors, patients with BT had lower concentrations of Lp(a) than those without BT; however, only TCZ-treated patients achieved statistically significant differences (?: ?0.303, 95% confidence interval: ?0.558 to ?0.047; P = .02). Conclusions RA patients treated with TCZ show lower plasma concentrations of Lp(a) compared with patients without BT. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10902/12093 |
| url |
http://hdl.handle.net/10902/12093 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Journal of Clinical Lipidology (2017), Volume 11, Issue 3, May-June 2017, Pages 749-756.e3 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
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Universidad de Cantabria (UC) |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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1869413084842426368 |
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15.300719 |