B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation

Hematopoiesis is a highly regulated process that, starting from hematopoietic stem cells (HSCs) with self-renewal capacity in the adult human bone marrow, is able to generate all different types of mature blood cells. The classical view of hematopoiesis defines binary branching points from these HSC...

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Autores: Bueno Costa, Alberto, Piñeyro, David, Soler, Marta, Javierre, Biola M., Raurell Vila, Helena, Subirana-Granés, Marc, Pasquali, Lorenzo, Martí-Climent, Josep M., Esteller, Manel, 1968-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/156080
Acceso en línea:https://hdl.handle.net/2445/156080
Access Level:acceso abierto
Palabra clave:Cèl·lules B
Leucèmia
ADN
Metilació
B cells
Leukemia
DNA
Methylation
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spelling B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulationBueno Costa, AlbertoPiñeyro, DavidSoler, MartaJavierre, Biola M.Raurell Vila, HelenaSubirana-Granés, MarcPasquali, LorenzoMartí-Climent, Josep M.Esteller, Manel, 1968-Cèl·lules BLeucèmiaADNMetilacióB cellsLeukemiaDNAMethylationHematopoiesis is a highly regulated process that, starting from hematopoietic stem cells (HSCs) with self-renewal capacity in the adult human bone marrow, is able to generate all different types of mature blood cells. The classical view of hematopoiesis defines binary branching points from these HSCs that segregate lineages and direct differentiation to terminally differentiated functional cell types. However, the described hierarchical model can be complemented with the emerging data that suggest the existence of hematopoietic stem and progenitor cells with a continuum of transitory differentiation stages, including cells with early lineage priming that generate distinct blood cell types according to the physiological or pathological environment. In this context, there are increasing data of hematopoietic plasticity and cell lineage conversion, particularly in leukemogenesis. Examples of transdifferentiation include B-cell lymphomas that can transform to histiocytic/dendritic cell sarcoma, erythroid/megakaryocytic lineages changing to granulomonocytic-like lineage upon use of a histone demethylase LSD1 inhibitor or B-ALL (acute lymphoblastic leukemia) patients that evaded CD19-directed antibody therapy (blinatumomab) by undergoing myeloid-lineage switch. Related to the latter scenario, lineage switching has also been reported as a cause of antigen loss in chimeric antigen receptor T-cell therapies, where B-ALL patients transdifferentiate in their relapse as acute myeloblastic leukemia in response to the initial CD19-directed immunotherapy. Due to the central role of epigenetics, particularly DNA methylation, in the successful generation of differentiated blood cell types and its plasticity during lineage specification, we wondered about its function in hematopoietic transdifferentiation, a largely unexplored field.Springer Nature2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/156080Articles publicats en revistes (Ciències Fisiològiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41375-019-0643-1Leukemia, 2020, vol. 34, num. 4, p. 1158-1162https://doi.org/10.1038/s41375-019-0643-1cc-by (c) Bueno Costa et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1560802026-05-27T06:46:51Z
dc.title.none.fl_str_mv B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
title B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
spellingShingle B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
Bueno Costa, Alberto
Cèl·lules B
Leucèmia
ADN
Metilació
B cells
Leukemia
DNA
Methylation
title_short B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
title_full B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
title_fullStr B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
title_full_unstemmed B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
title_sort B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
dc.creator.none.fl_str_mv Bueno Costa, Alberto
Piñeyro, David
Soler, Marta
Javierre, Biola M.
Raurell Vila, Helena
Subirana-Granés, Marc
Pasquali, Lorenzo
Martí-Climent, Josep M.
Esteller, Manel, 1968-
author Bueno Costa, Alberto
author_facet Bueno Costa, Alberto
Piñeyro, David
Soler, Marta
Javierre, Biola M.
Raurell Vila, Helena
Subirana-Granés, Marc
Pasquali, Lorenzo
Martí-Climent, Josep M.
Esteller, Manel, 1968-
author_role author
author2 Piñeyro, David
Soler, Marta
Javierre, Biola M.
Raurell Vila, Helena
Subirana-Granés, Marc
Pasquali, Lorenzo
Martí-Climent, Josep M.
Esteller, Manel, 1968-
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules B
Leucèmia
ADN
Metilació
B cells
Leukemia
DNA
Methylation
topic Cèl·lules B
Leucèmia
ADN
Metilació
B cells
Leukemia
DNA
Methylation
description Hematopoiesis is a highly regulated process that, starting from hematopoietic stem cells (HSCs) with self-renewal capacity in the adult human bone marrow, is able to generate all different types of mature blood cells. The classical view of hematopoiesis defines binary branching points from these HSCs that segregate lineages and direct differentiation to terminally differentiated functional cell types. However, the described hierarchical model can be complemented with the emerging data that suggest the existence of hematopoietic stem and progenitor cells with a continuum of transitory differentiation stages, including cells with early lineage priming that generate distinct blood cell types according to the physiological or pathological environment. In this context, there are increasing data of hematopoietic plasticity and cell lineage conversion, particularly in leukemogenesis. Examples of transdifferentiation include B-cell lymphomas that can transform to histiocytic/dendritic cell sarcoma, erythroid/megakaryocytic lineages changing to granulomonocytic-like lineage upon use of a histone demethylase LSD1 inhibitor or B-ALL (acute lymphoblastic leukemia) patients that evaded CD19-directed antibody therapy (blinatumomab) by undergoing myeloid-lineage switch. Related to the latter scenario, lineage switching has also been reported as a cause of antigen loss in chimeric antigen receptor T-cell therapies, where B-ALL patients transdifferentiate in their relapse as acute myeloblastic leukemia in response to the initial CD19-directed immunotherapy. Due to the central role of epigenetics, particularly DNA methylation, in the successful generation of differentiated blood cell types and its plasticity during lineage specification, we wondered about its function in hematopoietic transdifferentiation, a largely unexplored field.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/156080
url https://hdl.handle.net/2445/156080
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41375-019-0643-1
Leukemia, 2020, vol. 34, num. 4, p. 1158-1162
https://doi.org/10.1038/s41375-019-0643-1
dc.rights.none.fl_str_mv cc-by (c) Bueno Costa et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bueno Costa et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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