New genes in the evolution of the neural crest differentiation program

17 páginas, 4 tablas, 4 figuras.

Detalles Bibliográficos
Autores: Martínez-Morales, Juan Ramón, Henrich, Thorsten, Ramialison, Mirana, Wittbrodt, Joachim
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/40365
Acceso en línea:http://hdl.handle.net/10261/40365
Access Level:acceso abierto
Palabra clave:Cell differentiation
Cell lineages
Embryonic development
Genes
Neural crest
Phylogeny
Protein sorting signals
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spelling New genes in the evolution of the neural crest differentiation programMartínez-Morales, Juan RamónHenrich, ThorstenRamialison, MiranaWittbrodt, JoachimCell differentiationCell lineagesEmbryonic developmentGenesNeural crestPhylogenyProtein sorting signals17 páginas, 4 tablas, 4 figuras.BACKGROUND: Development of the vertebrate head depends on the multipotency and migratory behavior of neural crest derivatives. This cell population is considered a vertebrate innovation and, accordingly, chordate ancestors lacked neural crest counterparts. The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. These new findings revive the debate on what is new and what is ancient in the genetic program that controls neural crest formation. RESULTS: To determine the origin of neural crest genes, we analyzed Phenotype Ontology annotations to select genes that control the development of this tissue. Using a sequential blast pipeline, we phylogenetically classified these genes, as well as those associated with other tissues, in order to define tissue-specific profiles of gene emergence. Of neural crest genes, 9% are vertebrate innovations. Our comparative analyses show that, among different tissues, the neural crest exhibits a particularly high rate of gene emergence during vertebrate evolution. A remarkable proportion of the new neural crest genes encode soluble ligands that control neural crest precursor specification into each cell lineage, including pigmented, neural, glial, and skeletal derivatives. CONCLUSION: We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population.This study was supported by grants from the European Union (Strep Hygeia) and the German Research Foundation, Collaborative Research Centre 488.Peer reviewedBioMed Central201120112007info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/40365reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1186/gb-2007-8-3-r36info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/403652026-05-22T06:33:51Z
dc.title.none.fl_str_mv New genes in the evolution of the neural crest differentiation program
title New genes in the evolution of the neural crest differentiation program
spellingShingle New genes in the evolution of the neural crest differentiation program
Martínez-Morales, Juan Ramón
Cell differentiation
Cell lineages
Embryonic development
Genes
Neural crest
Phylogeny
Protein sorting signals
title_short New genes in the evolution of the neural crest differentiation program
title_full New genes in the evolution of the neural crest differentiation program
title_fullStr New genes in the evolution of the neural crest differentiation program
title_full_unstemmed New genes in the evolution of the neural crest differentiation program
title_sort New genes in the evolution of the neural crest differentiation program
dc.creator.none.fl_str_mv Martínez-Morales, Juan Ramón
Henrich, Thorsten
Ramialison, Mirana
Wittbrodt, Joachim
author Martínez-Morales, Juan Ramón
author_facet Martínez-Morales, Juan Ramón
Henrich, Thorsten
Ramialison, Mirana
Wittbrodt, Joachim
author_role author
author2 Henrich, Thorsten
Ramialison, Mirana
Wittbrodt, Joachim
author2_role author
author
author
dc.subject.none.fl_str_mv Cell differentiation
Cell lineages
Embryonic development
Genes
Neural crest
Phylogeny
Protein sorting signals
topic Cell differentiation
Cell lineages
Embryonic development
Genes
Neural crest
Phylogeny
Protein sorting signals
description 17 páginas, 4 tablas, 4 figuras.
publishDate 2007
dc.date.none.fl_str_mv 2007
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/40365
url http://hdl.handle.net/10261/40365
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1186/gb-2007-8-3-r36
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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