Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?

Aging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both ather...

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Detalles Bibliográficos
Autores: del Campo, Lara, Hamczyk, Magda R., Andres, Vicente, Martinez-Gonzalez, Jose, Rodriguez, Cristina
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:español
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7967
Acceso en línea:http://hdl.handle.net/20.500.12105/7967
Access Level:acceso abierto
Palabra clave:Age Factors
Aging
Cardiovascular Diseases
Cardiovascular System
Humans
Lamin Type A
Myocardial Infarction
Progeria
Risk Factors
Stroke
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spelling Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?del Campo, LaraHamczyk, Magda R.Andres, VicenteMartinez-Gonzalez, JoseRodriguez, CristinaAge FactorsAgingCardiovascular DiseasesCardiovascular SystemHumansLamin Type AMyocardial InfarctionProgeriaRisk FactorsStrokeAging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both atherosclerosis and heart failure significantly contribute to age-associated CVD morbidity and mortality. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by the synthesis of progerin, which is noted for accelerated aging and CVD. This mutant form of prelamin A induces generalised atherosclerosis, vascular calcification, and cardiac electrophysiological abnormalities, leading to premature aging and death, mainly due to myocardial infarction and stroke. This review discusses the main vascular structural and functional abnormalities during physiological and premature aging, as well as the mechanisms involved in the exacerbated CVD and accelerated aging induced by the accumulation of progerin and prelamin A. Both proteins are expressed in non-HGPS individuals, and physiological aging shares many features of progeria. Research into HGPS could therefore shed light on novel mechanisms involved in the physiological aging of the cardiovascular system.Ministerio de Economía, Industria y Competitividad (España)Instituto de Salud Carlos IIIUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Fundación La Marató TV3Progeria Research FoundationCentro de Investigación Biomedica en Red - CIBERFundación ProCNIC20192019-07-1920182018-06-0120182018-06-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7967reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)EspañolspaES SAF2016-79490-R Not availableES RD12 0042ES BES-2011-043938 Not availableES SEV-2015-0505 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/79672026-06-12T12:43:37Z
dc.title.none.fl_str_mv Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
title Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
spellingShingle Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
del Campo, Lara
Age Factors
Aging
Cardiovascular Diseases
Cardiovascular System
Humans
Lamin Type A
Myocardial Infarction
Progeria
Risk Factors
Stroke
title_short Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
title_full Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
title_fullStr Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
title_full_unstemmed Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
title_sort Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
dc.creator.none.fl_str_mv del Campo, Lara
Hamczyk, Magda R.
Andres, Vicente
Martinez-Gonzalez, Jose
Rodriguez, Cristina
author del Campo, Lara
author_facet del Campo, Lara
Hamczyk, Magda R.
Andres, Vicente
Martinez-Gonzalez, Jose
Rodriguez, Cristina
author_role author
author2 Hamczyk, Magda R.
Andres, Vicente
Martinez-Gonzalez, Jose
Rodriguez, Cristina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía, Industria y Competitividad (España)
Instituto de Salud Carlos III
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Fundación La Marató TV3
Progeria Research Foundation
Centro de Investigación Biomedica en Red - CIBER
Fundación ProCNIC
dc.subject.none.fl_str_mv Age Factors
Aging
Cardiovascular Diseases
Cardiovascular System
Humans
Lamin Type A
Myocardial Infarction
Progeria
Risk Factors
Stroke
topic Age Factors
Aging
Cardiovascular Diseases
Cardiovascular System
Humans
Lamin Type A
Myocardial Infarction
Progeria
Risk Factors
Stroke
description Aging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both atherosclerosis and heart failure significantly contribute to age-associated CVD morbidity and mortality. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by the synthesis of progerin, which is noted for accelerated aging and CVD. This mutant form of prelamin A induces generalised atherosclerosis, vascular calcification, and cardiac electrophysiological abnormalities, leading to premature aging and death, mainly due to myocardial infarction and stroke. This review discusses the main vascular structural and functional abnormalities during physiological and premature aging, as well as the mechanisms involved in the exacerbated CVD and accelerated aging induced by the accumulation of progerin and prelamin A. Both proteins are expressed in non-HGPS individuals, and physiological aging shares many features of progeria. Research into HGPS could therefore shed light on novel mechanisms involved in the physiological aging of the cardiovascular system.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-01
2018
2018-06-01
2019
2019-07-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/7967
url http://hdl.handle.net/20.500.12105/7967
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.relation.none.fl_str_mv ES SAF2016-79490-R Not available
ES RD12 0042
ES BES-2011-043938 Not available
ES SEV-2015-0505 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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