The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients

Colorectal cancer (CRC) is one of the most common cancers in Western countries and remains the second most common cause of cancer death worldwide. Many studies show the importance of diet and lifestyle in the incidence of CRC, as well as in CRC prevention. However, this review summarizes those studi...

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Authors: Collado, Manuel, Castillo, Marién, Muñoz de Mier, G. J., Pinta, Carolina De La, Peña Maroto, Cristina
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/377101
Online Access:http://hdl.handle.net/10261/377101
Access Level:Open access
Keyword:Colorectal cancer
Tumor microenvironment
Diet
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spelling The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer PatientsCollado, ManuelCastillo, MariénMuñoz de Mier, G. J.Pinta, Carolina De LaPeña Maroto, CristinaColorectal cancerTumor microenvironmentDietColorectal cancer (CRC) is one of the most common cancers in Western countries and remains the second most common cause of cancer death worldwide. Many studies show the importance of diet and lifestyle in the incidence of CRC, as well as in CRC prevention. However, this review summarizes those studies that analyze the impact of nutrition on tumor microenvironment modulation and cancer progression. We review the available information about the effects of specific nutrients on cancer cell progression and on the different cells within the tumor microenvironment. Diet and nutritional status in the clinical management of colorectal cancer patients are also analyzed. Finally, future perspectives and challenges are discussed, with a view to improving CRC treatments by employing nutritional approaches. These promise great benefits and will eventually improve CRC patients’ survival.This research is supported by PI20/00602 and FI21/00132 from the Instituto de Salud Carlos III and co-financed by the European Development Regional Fund (FEDER) “A way to achieve Europe” (ERDF); by “CIBER de Cáncer”, CB16/12/00273 from the Instituto de Salud Carlos IIIFEDER “A way to achieve Europe” (ERDF); and by Comunidad Autónoma de Madrid, S2022/BMD-7212.Peer reviewedMultidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIIEuropean CommissionComunidad de Madrid202520252023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/377101reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#S2022/BMD-7212/PRECICOLON-CMhttps://doi.org/10.3390/ijms24087317Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3771012026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
title The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
spellingShingle The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
Collado, Manuel
Colorectal cancer
Tumor microenvironment
Diet
title_short The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
title_full The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
title_fullStr The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
title_full_unstemmed The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
title_sort The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
dc.creator.none.fl_str_mv Collado, Manuel
Castillo, Marién
Muñoz de Mier, G. J.
Pinta, Carolina De La
Peña Maroto, Cristina
author Collado, Manuel
author_facet Collado, Manuel
Castillo, Marién
Muñoz de Mier, G. J.
Pinta, Carolina De La
Peña Maroto, Cristina
author_role author
author2 Castillo, Marién
Muñoz de Mier, G. J.
Pinta, Carolina De La
Peña Maroto, Cristina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Comunidad de Madrid
dc.subject.none.fl_str_mv Colorectal cancer
Tumor microenvironment
Diet
topic Colorectal cancer
Tumor microenvironment
Diet
description Colorectal cancer (CRC) is one of the most common cancers in Western countries and remains the second most common cause of cancer death worldwide. Many studies show the importance of diet and lifestyle in the incidence of CRC, as well as in CRC prevention. However, this review summarizes those studies that analyze the impact of nutrition on tumor microenvironment modulation and cancer progression. We review the available information about the effects of specific nutrients on cancer cell progression and on the different cells within the tumor microenvironment. Diet and nutritional status in the clinical management of colorectal cancer patients are also analyzed. Finally, future perspectives and challenges are discussed, with a view to improving CRC treatments by employing nutritional approaches. These promise great benefits and will eventually improve CRC patients’ survival.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/377101
url http://hdl.handle.net/10261/377101
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
S2022/BMD-7212/PRECICOLON-CM
https://doi.org/10.3390/ijms24087317
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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